Abstract
Vermiform Appendix Tumours: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM7 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the commoner non-carcinoma malignancies that are encountered at this site in diagnostic practice.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
- 1.
1See section “Mucocoele” (Appendiceal Mucinous Neoplasms).
Bibliography
Bosman FT, Carneiro F. WHO classification of tumours of the digestive system. 4th ed. Lyon: IARC press; 2010.
Bradley RF, Cortina G, Geisinger KR. Pseudomyxoma peritonei: review of the controversy. Curr Diagn Pathol. 2007;13:410–6.
Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B. Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases. J Clin Pathol. 2012;65:919–23.
Day DW, Jass JR, Price AB, Shepherd NA, Sloan JM, Talbot IC, Warren BF, Williams GT. Morson and Dawson’s gastrointestinal pathology. 4th ed. Oxford: Blackwell Sciences; 2003.
Misdraji J. Epithelial neoplasms and other epithelial lesions of the appendix (excluding carcinoid tumours). Curr Diagn Pathol. 2005a;11:60–71.
Misdraji J. Neuroendocrine tumours of the appendix. Curr Diagn Pathol. 2005b;11:180–93.
Misdraji J, Yantiss RK, Graeme-Cook FM, Baliss UJ, Young RH. Appendiceal mucinous neoplasm: a clinicopathologic analysis of 107 cases. Am J Surg Pathol. 2003;27:1089–103.
Odze RD, Goldblum JR. Surgical pathology of the GI tract, liver, biliary tract and pancreas. 2nd ed. Philadelphia: Saunders/Elsevier; 2009.
Plockinger U, Rindi G, Arnold R, Eriksson B, Krenning EP, de Herder WW, et al. Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS). Neuroendocrinology. 2004;80:394–424.
Riddell RH, Petras RE, Williams GT, Sobin LH. Tumors of the intestines. Atlas of tumor pathology. 3rd Series. Fascicle 32. Washington: AFIP; 2003.
Ronnett BM, Kurman RJ, Shmookler BM, Sugarbaker PH, Young RH. The morphologic spectrum of ovarian metastases of appendiceal adenocarcinomas. Am J Surg Pathol. 1997;21:1144–55.
Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O’Reilly E, et al. Pathologic classification and clinical behaviour of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol. 2008;32:1429–43.
The Royal College of Pathologists: Cancer Datasets (Oesophageal Carcinoma, Gastric Carcinoma, Carcinomas of the Pancreas, ampulla of Vater and Common Bile Duct, Colorectal Cancer, Gastrointestinal Stromal Tumours (GISTs), Liver Resection Specimens and Liver Biopsies for Primary and Metastatic Carcinoma, Endocrine Tumours of the Gastrointestinal Tract including Pancreas) and Tissue Pathways (Gastrointestinal and Pancreatobiliary Pathology, Liver Biopsies for the Investigation of Medical Disease and for Focal Liver Lesions). Accessed at http://www.rcpath.org/index.asp?PageID=254.
Van Eeden S, Offerhaus GJA, Hart AAM, Boerrigter L, Nederlof PM, Porter E, van Velthuysen MLF. Goblet cell carcinoid of the appendix: a specific type of carcinoma. Histopathology. 2007;51:763–73.
Younes M, Katikaneni PR, Lechago J. Association between mucosal hyperplasia of the appendix and adenocarcinoma of the colon. Histopathology. 1995;26:33–7.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
Allen, D.C. (2013). Vermiform Appendix Tumours. In: Histopathology Reporting. Springer, London. https://doi.org/10.1007/978-1-4471-5263-7_6
Download citation
DOI: https://doi.org/10.1007/978-1-4471-5263-7_6
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-5262-0
Online ISBN: 978-1-4471-5263-7
eBook Packages: MedicineMedicine (R0)