Abstract
Malignant Mesothelioma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM7 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the commoner non-carcinoma malignancies that are encountered at this site in diagnostic practice.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
Abutaily AS, Addis BJ, Roche WR. Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a central evaluation of new antibodies. J Clin Pathol. 2002;55:662–8.
Addis B, Roche H. Problems in mesothelioma diagnosis. Histopathology. 2009;54:55–68.
Attanoos RL, Gibbs AR. Asbestos-related deaths. Curr Diagn Pathol. 2002;8:373–83.
Attanoos RL, Gibbs AR. Asbestos-related neoplasia. In: Lowe DG, Underwood JCE, editors. Recent advances in histopathology, vol. 20. London: RSM Press; 2003. p. 73–8.
Attanoos RL, Gibbs AR. The pathology associated with therapeutic procedures in malignant mesothelioma. Histopathology. 2004;45:393–7.
Attanoos RL, Gibbs AR. The comparative accuracy of different pleural biopsy techniques in the diagnosis of malignant mesothelioma. Histopathology. 2008;53:340–4.
Battifora H, McCaughey WT. Tumors of the serosal membranes. Atlas of tumor pathology. 3rd series. Fascicle 15. Washington: AFIP; 1995.
Corrin B, Nicholson AG. Pathology of the lungs. 3rd ed. London: Churchill Livingstone; 2011.
Downer NJ, Ali NJ, Au-Yong ITH. Investigating pleural thickening. BMJ. 2013;346:35–7.
Guinee Jr DG. Update on pulmonary and pleural lymphoproliferative disorders. Diagn Histopathol. 2008;14:474–98.
Nash G, Otis CN. Protocol for the examination of specimens from patients with malignant pleural mesothelioma. Arch Pathol Lab Med. 1999;123:39–44.
Ordonez NG. The immunohistochemical diagnosis of mesothelioma. A comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 2003;27:1031–51.
Rena O. Extrapleural pneumonectomy in malignant mesothelioma. BMJ. 2011;343:1186.
Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, WHO Classification of Tumours. Pathology and genetics. Tumours of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004.
Wittekind CF, Greene FL, Hutter RVP, Klimpfinger M, Sobib LH. TNM atlas: illustrated guide to the TNM/pTNM classification of malignant tumours. 5th ed. Berlin: Springer; 2005.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag London
About this chapter
Cite this chapter
Allen, D.C. (2013). Malignant Mesothelioma. In: Histopathology Reporting. Springer, London. https://doi.org/10.1007/978-1-4471-5263-7_18
Download citation
DOI: https://doi.org/10.1007/978-1-4471-5263-7_18
Published:
Publisher Name: Springer, London
Print ISBN: 978-1-4471-5262-0
Online ISBN: 978-1-4471-5263-7
eBook Packages: MedicineMedicine (R0)