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Liver Carcinoma

  • Derek C. Allen
Chapter

Abstract

Liver Carcinoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate timeframe, and clinically relevant to patient management and prognosis. Summary details of the common cancers given at this site include: gross description, histological types, tumour grade/differentiation, extent of local tumour spread, lymphovascular invasion, lymph node involvement, and the status of excision margins. Current WHO Classifications of Malignant Tumours and TNM7 are referenced. Notes are provided on other associated pathology, contemporary use of immunohistochemistry, updates on the role of evolving molecular tests, and the use of these ancillary techniques as biomarkers in diagnosis, and prediction of prognosis and treatment response. A summary is given of the commoner non-carcinoma malignancies that are encountered at this site in diagnostic practice.

Keywords

Hepatocellular Carcinoma Focal Nodular Hyperplasia Primary Liver Cancer Intrahepatic Cholangiocarcinoma Dysplastic Nodule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Bibliography

  1. Anthony PP. Hepatocellular carcinoma: an overview. Histopathology. 2001;39:109–18.PubMedCrossRefGoogle Scholar
  2. Beckingham IJ, editor. ABC of liver, pancreas and gall bladder diseases. London: BMJ Books; 2001.Google Scholar
  3. Bellamy COC, Maxwell RS, Prost S, Azodo IA, Powell JJ, Manning JR. The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre. Histopathology. 2013;62:431–45.PubMedCrossRefGoogle Scholar
  4. Burt AD, Portmann BC, Ferrell LD. MacSween’s pathology of the liver. 5th ed. Edinburgh/New York: Churchill Livingstone; 2007.Google Scholar
  5. Carter D, Russell RCG, Pitt HA, Bismuth H, editors. Rob and Smith’s operative surgery: hepatobiliary and pancreatic surgery. 5th ed. London: Chapman and Hall; 1996.Google Scholar
  6. Ishak KG, Goodman ZD, Stocker JT. Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology. 3rd series. Fascicle 31. Washington: AFIP; 2001.Google Scholar
  7. Kumagi T, Hiasa Y, Hirschfield GM. Hepatocellular carcinoma for the non-specialist. BMJ. 2009;339:1366–70.CrossRefGoogle Scholar
  8. Leong TYM, Wannakrairot P, Lee ES, Leong ASY. Pathology of cholangiocarcinoma. Curr Diagn Pathol. 2007;13:54–64.CrossRefGoogle Scholar
  9. Paterson AC, Cooper K. Tumours and tumour-like lesions of the hepatic parenchyma. Curr Diagn Pathol. 2005;11:19–53.CrossRefGoogle Scholar
  10. Quaglia A, Battacharjya S, Dhillon P. Limitations of the histopathological diagnosis and prognostic assessment of hepatocellular carcinoma. Histopathology. 2001;38:167–74.PubMedCrossRefGoogle Scholar
  11. Ryder S. Predicting survival in early hepatocellular carcinoma. Gut. 2005;54:328–9.PubMedCrossRefGoogle Scholar
  12. Scheuer PJ, Lefkowitch JH. Liver biopsy interpretation. 8th ed. London: Saunders/Elsevier; 2010.Google Scholar
  13. The Royal College of Pathologists: Cancer Datasets (Oesophageal Carcinoma, Gastric Carcinoma, Carcinomas of the Pancreas, ampulla of Vater and Common Bile Duct, Colorectal Cancer, Gastrointestinal Stromal Tumours (GISTs), Liver Resection Specimens and Liver Biopsies for Primary and Metastatic Carcinoma, Endocrine Tumours of the Gastrointestinal Tract including Pancreas) and Tissue Pathways (Gastrointestinal and Pancreatobiliary Pathology, Liver Biopsies for the Investigation of Medical Disease and for Focal Liver Lesions). Accessed at http://www.rcpath.org/index.asp?PageID=254.
  14. Wittekind CF, Greene FL, Hutter RVP, Klimpfinger M, Sobib LH. TNM atlas: illustrated guide to the TNM/pTNM classification of malignant tumours. 5th ed. Berlin: Springer; 2005.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Derek C. Allen
    • 1
  1. 1.Histopathology LaboratoryBelfast City HospitalBelfastUK

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