Perivascular Renal Denervation (PVRDTM): Chemical Renal Denervation with Micro-Doses of Ethanol Using the PeregrineTM Renal Denervation Device

  • Tim A. Fischell
  • Félix Vega
  • Vartan E. Ghazarossian


In the 1930s–1950s surgical renal sympathectomy was used to treat severe hypertension [1–3]. Despite a successful lowering of blood pressure (BP) observed with surgical denervation, this technique was abandoned due to a relatively high morbidity and mortality, and as a result of the development of more effective oral antihypertensive medications


Renal Artery Renal Denervation Renal Sympathetic Denervation Refractory Hypertension Intimal Surface 



We wish to acknowledge the expert technical contributions of Jeff A. Burke, Phil C. Burke, Andy E. Denison, and Chris S. Hayden from REV-1 Engineering.

Disclosures, Conflict of Interest

TAF and VEG are principles, employees and co-founders of Ablative Solutions and have equity positions in the company. FV has is a paid consultant working with Ablative Solutions, Inc.


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Copyright information

© Springer-Verlag London 2015

Authors and Affiliations

  • Tim A. Fischell
    • 1
    • 2
  • Félix Vega
    • 3
  • Vartan E. Ghazarossian
    • 2
  1. 1.Heart Institute at Borgess Medical CenterKalamazooUSA
  2. 2.Ablative Solutions, Inc.Kalamazoo/Menlo ParkUSA
  3. 3.San FranciscoUSA

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