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Laser Catheter Ablation of Cardiac Arrhythmias: Experimental and Basic Research and Clinical Results

  • Robert SplinterEmail author

Abstract

The treatment of cardiac arrhythmias remains a challenge to improvement the general and specific quality of life parameters for people suffering from ventricular and atrial drug-resistant irregular heart-rates. The treatment options for cardiac arrhythmias have experienced many changes over the past decades. Both the mechanism-of-action has undergone changes as has the focus of the clinical targets. The use of laser light has been verified to provide opportunities to change the electrophysiological communication pathway and the inherent contractile sequence as well as contraction mechanical behavior. Both ventricular and atrial tissue can be modified by photocoagulation, rendering the coagulated tissue as an insulator, hence redirecting the depolarization wavefront. The deliberate modification of the depolarization pathway has been proven effective in providing palliation and cure for various arrhythmogenic disorders. The use of short-wavelength near infrared light appears to offer the best solutions for deep coagulation of diseased tissue while preserving the functionality of surrounding healthy cardiac muscle. In ventricular treatments of arrhythmias the success rate has been shown to exceed 65 % and for atrial arrhythmias success of 90 % or better has been established.

Keywords

Drug-resistant irregular heart rate Laser light Electrophysiological communication Contractile sequence Photocoagulation Depolarization 

Notes

Acknowledgments

In acknowledgment for the clinical work, scientific contributions and practical conversations the following people require honorable mention: Dr. Robert H. Svenson, Dr. Laszlo Littmann, Dr. J Selle, Dr. John J. Gallagher, Gregory Brucker, PhD, Kathleen Tuntelder-Seifert, Jan Tuntelder, Kathy R. Dezern, Katie Linder, Ernest Pruitt, Dr. Andre d’Avila, Dr. Eduardo Sosa, and Sergei Y Semenov, PhD.

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© Springer-Verlag London 2015

Authors and Affiliations

  1. 1.Department of R&DSplinter ConsultantsGrahamUSA

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