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Long-Term Effects of Calcium Channel Blockers on Central and Peripheral Arteries

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Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

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Abstract

Calcium channel blockers (CCBs) are reported to be more effective in reducing cerebrovascular events than other antihypertensive drugs in hypertensive patients. Large artery stiffness could be partly reduced through the reduction of the distending pressure and arterial structural changes by long-term treatment with CCBs. Because CCBs reduce the magnitude of wave reflection by attenuating the vascular tone of peripheral muscular arteries, CCBs cause a greater fall in the central aortic pressure than did β-blockers or diuretics, despite no difference in peripheral (brachial) pressure. The de-stiffening of the large arteries and the dilation of peripheral muscular arteries by CCBs might be underlying mechanisms of the significant reductions in central pressure and blood pressure variability, thus reducing carotid atherosclerosis, cerebral arteriosclerotic damage, and cerebrovascular events in hypertensive patients.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan

    Yoshio Matsui MD, PhD

  2. Department of Internal Medicine, Iwakuni Medical Center, 3-6-12 Muronoki, Iwakuni, Yamaguchi, 740-0021, Japan

    Yoshio Matsui MD, PhD

  3. Department of Cardiovascular and Hypertension, St Vincent’s Clinic, University of New South Wales, Victor Chang Cardiac Research Institute, Suite 810 St Vincent Clinic, 438 Victoria Street, Darlinghurst, Sydney, NSW, 2010, Australia

    Michael F. O’Rourke MD, DSc

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  1. Yoshio Matsui MD, PhD
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Correspondence to Yoshio Matsui MD, PhD .

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Editors and Affiliations

  1. Hôtel-Dieu Hospital Diagnosis and Therapeutics Center, Paris Descartes University, Paris, Paris, France

    Michel E. Safar

  2. St Vincent Clinic and Hospital, University of New South Wales, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia

    Michael F. O'Rourke

  3. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

    Edward D. Frohlich

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Matsui, Y., O’Rourke, M.F. (2014). Long-Term Effects of Calcium Channel Blockers on Central and Peripheral Arteries. In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_44

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