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De-stiffening Strategy, Sodium Balance, and Blockade of the Renin–Angiotensin System

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Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

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Abstract

Arterial stiffening, especially of the large elastic arteries, is a fundamental vascular aging trait, which is, however, accelerated in the presence of genetic and environmental factors. It is an early marker of subclinical arterial disease but also a well-established biomarker of clinical cardiovascular disease events and cardiovascular disease mortality. Preventive strategies calcium channel blockade and allopurinol, a careful individualized de-stiffening strategy on the basis of sodium balance, in combination with the renin–angiotensin system blockade, appears to be the currently available optimal strategy.

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Authors and Affiliations

  1. Cardiovascular Research Laboratory and Hypertension Center, First Department of Propedeutic and Internal Medicine, “Laiko” Hospital, Medical School, National and Kapodistrian University of Athens, 17 Ag. Thoma str, Athens, 117 25, Greece

    Athanase D. Protogerou MD, PhD

  2. Department of Medicine, Diagnosis and Therapeutics Center, Hôtel-Dieu Hospital, Assistance Publique des Hôpitaux de Paris, Paris Descartes University, 1, Place du Parvis Notre-Dame, 75181, Paris, France

    Michel E. Safar MD & Jacques Blacher MD, PhD

  3. Institut de Pharmacologie, Universitye de Sherbrooke, 3001, 12 eme avenue Nord, J1H5N4, Sherbrooke, QC, Canada

    Gerard E. Plante

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  1. Athanase D. Protogerou MD, PhD
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  2. Michel E. Safar MD
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  3. Gerard E. Plante
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  4. Jacques Blacher MD, PhD
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Correspondence to Athanase D. Protogerou MD, PhD .

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Editors and Affiliations

  1. Hôtel-Dieu Hospital Diagnosis and Therapeutics Center, Paris Descartes University, Paris, Paris, France

    Michel E. Safar

  2. St Vincent Clinic and Hospital, University of New South Wales, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia

    Michael F. O'Rourke

  3. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

    Edward D. Frohlich

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Protogerou, A.D., Safar, M.E., Plante, G.E., Blacher, J. (2014). De-stiffening Strategy, Sodium Balance, and Blockade of the Renin–Angiotensin System. In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_43

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