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Nitrate: The Ideal Drug Action for Isolated Systolic Hypertension in Elderly?

  • Xiong J. Jiang
  • Michael F. O’RourkeEmail author
Chapter

Abstract

Nitrates such as nitroglycerine and isosorbide mononitrate are unique drugs, and at least in theory ideal for treating Isolated Systolic Hypertension in the Elderly (ISHE). Early wave reflection from aortic stiffening increases late systolic pressure in the ascending aorta and left ventricle, and is the cause of ISHE, but diastolic pressure and mean pressure are normal. Nitrates decrease or abolish wave reflection from peripheral arterioles, “trapping” this within the peripheral arterial networks (Yaginuma et al. Cardiovasc Res 20:153–160, 1986).

While having the most favourable of all mechanisms for treatment of angina pectoris and ISHE, nitrates have disadvantages over conventional modern anti-anginal and antihypertensive drugs, and so are usually used in conjunction with other drugs.

The purpose of this chapter is to describe the actions of nitrates, the properties that make them useful, and those which can detract from their use in clinical medicine. All have been clarified by modern concepts of aortic elasticity, arteriolar resistance, wave reflection, and pressure pulse wave analysis. Surprisingly, few if any of the mechanistic concepts are considered in contemporary journals and textbooks.

Keywords

Nitrates Systolic hypertension Central aortic pressure Wave reflection Tolerance 

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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Department of Cardiology, Hypertension CentreFuwai Hospital, Cardiovascular Institute, Chinese Academy of Medical Sciences, National Centre for Cardiovascular Diseases, Peking Union Medical CollegeBeijingChina
  2. 2.Department of Cardiovascular and HypertensionSt. Vincent’s Clinic, University of New South Wales, Victor Chang Cardiac Research InstituteDarlinghurst, SydneyAustralia

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