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Arterial Stiffness, Central Blood Pressure and Cardiac Remodelling: From Cardiac Hypertrophy to Heart Failure

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Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

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Abstract

Over the past several decades much has been learned about arterial stiffness and central blood pressure (BP) and their relations to left ventricular (LV) remodelling and hypertrophy. In addition, the impact of central hemodynamics on LV performance and the development of clinical heart failure is under active investigation and is of particular importance from a public health and therapeutic standpoint. The ability to examine these topics has been vastly accelerated by the development of reliable, noninvasive technology to permit evaluation of cardiac and vascular structure and function on an epidemiologic scale. The present review will discuss data regarding the interaction of arterial stiffness and central BP with LV structure and function; the impact of arterial stiffness on the development of heart failure, particularly with preserved ejection fraction, will also be discussed.

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Abbreviations

AUC:

Area under the curve

BP:

Blood pressure

HFPEF:

Heart failure with preserved ejection fraction

LV:

Left ventricular

LVETi:

Left ventricular ejection time index

NT-proBNP:

N-terminal pro-B-type natriuretic peptides

PP:

Pulse pressure

ROC:

Receiver operating characteristic

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Author information

Authors and Affiliations

  1. Greenberg Division of Cardiology, New York Presbyterian Hospital, Weill Cornell Medical College, 525 East 68th Street, New York, NY, 10021, USA

    Mary J. Roman MD & Richard B. Devereux MD

Authors
  1. Mary J. Roman MD
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  2. Richard B. Devereux MD
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Corresponding author

Correspondence to Mary J. Roman MD .

Editor information

Editors and Affiliations

  1. Hôtel-Dieu Hospital Diagnosis and Therapeutics Center, Paris Descartes University, Paris, Paris, France

    Michel E. Safar

  2. St Vincent Clinic and Hospital, University of New South Wales, Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, New South Wales, Australia

    Michael F. O'Rourke

  3. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA

    Edward D. Frohlich

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Roman, M.J., Devereux, R.B. (2014). Arterial Stiffness, Central Blood Pressure and Cardiac Remodelling: From Cardiac Hypertrophy to Heart Failure. In: Safar, M., O'Rourke, M., Frohlich, E. (eds) Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-5198-2_24

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  • DOI: https://doi.org/10.1007/978-1-4471-5198-2_24

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  • Online ISBN: 978-1-4471-5198-2

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