Arterial Stiffness, Central Blood Pressure and Cardiac Remodelling: From Cardiac Hypertrophy to Heart Failure

  • Mary J. RomanEmail author
  • Richard B. Devereux


Over the past several decades much has been learned about arterial stiffness and central blood pressure (BP) and their relations to left ventricular (LV) remodelling and hypertrophy. In addition, the impact of central hemodynamics on LV performance and the development of clinical heart failure is under active investigation and is of particular importance from a public health and therapeutic standpoint. The ability to examine these topics has been vastly accelerated by the development of reliable, noninvasive technology to permit evaluation of cardiac and vascular structure and function on an epidemiologic scale. The present review will discuss data regarding the interaction of arterial stiffness and central BP with LV structure and function; the impact of arterial stiffness on the development of heart failure, particularly with preserved ejection fraction, will also be discussed.


Arterial stiffness Central blood pressure Left ventricular hypertrophy Heart failure 



Area under the curve


Blood pressure


Heart failure with preserved ejection fraction


Left ventricular


Left ventricular ejection time index


N-terminal pro-B-type natriuretic peptides


Pulse pressure


Receiver operating characteristic


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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Greenberg Division of CardiologyNew York Presbyterian Hospital, Weill Cornell Medical CollegeNew YorkUSA

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