Arteries and Veins
Arterial thrombosis is one of the features which distinguishes Hughes syndrome from other clotting disorders. Hughes syndrome can present with major thrombosis both in limbs and internal organs. Arterial thrombosis can also present in a different guise, that of localised thrombotic/stenotic lesions in organs such as the kidney, gut arteries, coronaries and cerebral vessels.
Venous thrombosis is common – up to 1 in 5 cases of DVT has been reported to have positive aPL (antiphospholipid antibody) tests.