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Approach to Diagnosis: Echocardiography

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Hypertrophic Cardiomyopathy

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Abstract

The diagnosis of HCM can be challenging. Echocardiography has become the primary method for the initial evaluation of patients with suspected hypertrophic cardiomyopathy. The integrated utilization of two-dimensional echocardiography, doppler echocardiography, and stress echocardiography allows for the evaluation of the presence and severity of LV wall thickness, diastolic dysfunction, LVOT obstruction and mitral regurgitation. Thus, echocardiography offers the clinician a comprehensive imaging modality in those with suspected HCM, those previously diagnosed, and those undergoing surveillance or therapeutic intervention. In this chapter, we detail the benefits of echocardiography for the diagnosis, monitoring, and management of those with suspected or known HCM.

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References

  1. Adelman AG, McLoughlin MJ, Marquis Y, et al. Left ventricular cineangiographic observations in muscular subaortic stenosis. Am J Cardiol. 1969;24:689–97.

    Article  CAS  PubMed  Google Scholar 

  2. Braunwald E, Lambrew CT, Rockoff SD, et al. Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients. Circulation. 1964;30 Suppl 4:3–119.

    PubMed  Google Scholar 

  3. Maron BJ, Gottdiener JS, Epstein SE. Patterns and significance of distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy. A wide angle, two dimensional echocardiographic study of 125 patients. Am J Cardiol. 1981;48:418–28.

    Article  CAS  PubMed  Google Scholar 

  4. Geske JB, Sorajja P, Nishimura RA, Ommen SR. Evaluation of left ventricular filling pressures by Doppler echocardiography in patients with hypertrophic cardiomyopathy: correlation with direct left atrial pressure measurement at cardiac catheterization. Circulation. 2007;116:2702–8.

    Article  PubMed  Google Scholar 

  5. Yang H, Sun JP, Lever HM, Popovic ZB, Drinko JK, Greenberg NL, et al. Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy. J Am Soc Echocardiogr. 2003;16:233–9.

    Article  PubMed  Google Scholar 

  6. Maron BJ, McKenna WJ, Danielson GK, et al. American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the European Society of Cardiology Committee for Practice Guidelines. J Am Coll Cardiol. 2003;42:1687–713.

    Article  PubMed  Google Scholar 

  7. Feigenbaum H, Armstrong WF, Ryan T, Feigenbaum H. Feigenbaum’s echocardiography. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 139. Print.

    Google Scholar 

  8. Oh JK, Seward JB, Jamil Tajik A. The echo manual. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 22. Print.

    Google Scholar 

  9. Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, Moss AJ, Seidman CE, Young JB. Contemporary definitions and classification of the cardiomyopathies. Circulation. 2006;113:1807–16.

    Article  PubMed  Google Scholar 

  10. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124:2761–96.

    Article  PubMed  Google Scholar 

  11. Harvey F, Armstrong WF, Ryan T, Feigenbaum H. Feigenbaum’s echocardiography. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 181. Print.

    Google Scholar 

  12. Nistri S, Olivotto I, Betocchi S, Losi MA, Valsecchi G, Pinamonti B, Conte MR, Casazza F, Galderisi M, Maron BJ, Cecchi F. Prognostic significance of left atrial size in patients with hypertrophic cardiomyopathy (from the Italian Registry for Hypertrophic Cardiomyopathy). Am J Cardiol. 2006;98:960–5.

    Article  PubMed  Google Scholar 

  13. Wigle ED, Sasson Z, Henderson MA, et al. Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review. Prog Cardiovasc Dis. 1985;28:1–83.

    Article  CAS  PubMed  Google Scholar 

  14. Maron BJ, Epstein SE. Hypertrophic cardiomyopathy. Recent observations regarding the specificity of three hallmarks of the disease: asymmetric septal hypertrophy, septal disorganization and systolic anterior motion of the anterior mitral leaflet. Am J Cardiol. 1980;45:141–54.

    Article  CAS  PubMed  Google Scholar 

  15. Williams LK, Frenneaux MP, Steeds RP. Echocardiography in hypertrophic cardiomyopathy diagnosis, prognosis, and role in management. Eur J Echocardiogr. 2009;10:iii9–14.

    Article  CAS  PubMed  Google Scholar 

  16. Wigle ED, Sasson Z, Henderson MA, et al. Hypertrophic cardiomyopathy. The importance of the site and the extent of hypertrophy. A review. Prog Cardiovasc Dis. 1985;28:1–83.

    Article  CAS  PubMed  Google Scholar 

  17. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124:2761–96.

    Article  PubMed  Google Scholar 

  18. Basavarajaiah S, Wilson M, Whyte G, Shah A, McKenna W, Sharma S. Prevalence of hypertrophic cardiomyopathy in highly trained athletes: relevance to pre-participation screening. J Am Coll Cardiol. 2008;51:1033–9.

    Article  PubMed  Google Scholar 

  19. Klues HG, Schiffers A, Maron BJ. Phenotypic spectrum and patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy: morphologic observations and significance as assessed by two-dimensional echocardiography in 600 patients. J Am Coll Cardiol. 1995;26:1699–708.

    Article  CAS  PubMed  Google Scholar 

  20. Spirito P, Maron BJ. Relation between extent of left ventricular hypertrophy and occurrence of sudden cardiac death in hypertrophic cardiomyopathy. J Am Coll Cardiol. 1990;15:1521–6. 20.

    Article  CAS  PubMed  Google Scholar 

  21. Spirito P, Bellone P, Harris KM, Bernabo P, Bruzzi P, Maron BJ. Magnitude of left ventricular hypertrophy and risk of sudden death in hypertrophic cardiomyopathy. N Engl J Med. 2000;342:1778–85.

    Article  CAS  PubMed  Google Scholar 

  22. Rickers C, Wilke NM, Jerosch-Herold M, Casey SA, Panse P, Panse N, Weil J, Zenovich AG, Maron BJ. Utility of cardiac magnetic resonance imaging in the diagnosis of hypertrophic cardiomyopathy. Circulation. 2005;112:855–61.

    Article  PubMed  Google Scholar 

  23. Martinez MW. Mid-cavitary obstruction in hypertrophic cardiomyopathy. Heart. 2008;94(10):1287.

    Article  CAS  PubMed  Google Scholar 

  24. Monserrat L, Hermida-Prieto M, Fernandez X, Rodríguez I, Dumont C, Cazón L, Cuesta MG, Gonzalez-Juanatey C, Peteiro J, Alvarez N, Penas-Lado M, Castro-Beiras A. Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects. Eur Heart J. 2007;28:1953–61.

    Article  CAS  PubMed  Google Scholar 

  25. McKenna WJ, Kleinebenne A, Nihoyannopoulos P, Foale R. Echocardiographic measurement of right ventricular wall thickness in hypertrophic cardiomyopathy: relation to clinical and prognostic features. J Am Coll Cardiol. 1988;1:351–8.

    Article  Google Scholar 

  26. Maron MS, Hauser TH, Dubrow E, Horst TA, Kissinger KV, Udelson JE, Manning WJ. Right ventricular involvement in hypertrophic cardiomyopathy. Am J Cardiol. 2007;100:1293–8.

    Article  PubMed  Google Scholar 

  27. Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989;2:358–67.

    Article  CAS  PubMed  Google Scholar 

  28. Maron BJ, Spirito P. Implications of left ventricular remodeling in hypertrophic cardiomyopathy. Am J Cardiol. 1998;81:1339–44.

    Article  CAS  PubMed  Google Scholar 

  29. Olivotto I, Girolami F, Nistri S, Rossi A, Rega L, Garbini F, Grifoni C, Cecchi F, Yacoub MH. The many faces of hypertrophic cardiomyopathy: from developmental biology to clinical practice. J Cardiovasc Transl Res. 2009;2:349–67.

    Article  PubMed  Google Scholar 

  30. Maron BJ, Spirito P. Implications of left ventricular remodeling in hypertrophic cardiomyopathy. Am J Cardiol. 1998;81:1339–44.

    Article  CAS  PubMed  Google Scholar 

  31. Fujiwara H, Onodera T, Tanaka M, Shirane H, Kato H, Yoshikawa J, Osakada G, Sasayama S, Kawai C. Progression from hypertrophic obstructive cardiomyopathy to typical dilated cardiomyopathy-like features in the end stage. Jpn Circ J. 1984;48:1210–4.

    Article  CAS  PubMed  Google Scholar 

  32. Harris KM, Spirito P, Maron MS, et al. Prevalence, clinical profile, and signifi cance of left ventricular remodeling in the end-stage phase of hypertrophic cardiomyopathy. Circulation. 2006;114:216–25.

    Article  PubMed  Google Scholar 

  33. Douglas PS, Garcia MJ, Haines DE, Lai WW, Manning WJ, Patel AR, Picard MH, Polk DM, Ragosta M, Ward RP, Weiner RB. ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 appropriate use criteria for echocardiography: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Society of Echocardiography, American Heart Association, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Critical Care Medicine, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance Endorsed by the American College of Chest Physicians. J Am Coll Cardiol. 2011;57:1126–66.

    Article  PubMed  Google Scholar 

  34. Feigenbaum H, Armstrong WF, Ryan T, Feigenbaum H. Feigenbaum’s echocardiography. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 184. Print.

    Google Scholar 

  35. Sachdev V, Shizukuda Y, Brenneman CL, Birdsall CW, Waclawiw MA, Arai AE, Mohiddin SA, Tripodi D, Fananapazir L, Plehn JF. Left atrial volumetric remodeling is predictive of functional capacity in nonobstructive hypertrophic cardiomyopathy. Am Heart J. 2005;149(4):730–6.

    Article  PubMed  Google Scholar 

  36. Yang H, et al. Enlarged left atrial volume in hypertrophic cardiomyopathy: a marker for disease severity. J Am Soc Echocardiogr. 2005;18(10):1074–82.

    Article  PubMed  Google Scholar 

  37. Hatle L, Angelsen B. Doppler ultrasound in cardiology. 2nd ed. Philadelphia: Lea & Febiger; 1985.

    Google Scholar 

  38. Izgi C, Akgun T, Men EE, Feray H. Systolic anterior motion of the mitral valve in the absence left ventricular hypertrophy: role of mitral leaflet elongation and papillary muscle displacement. Echocardiography. 2010; 27:E36–8.

    Google Scholar 

  39. Lefebvre XP, He S, Levine RA, Yoganathan AP. Systolic anterior motion of the mitral valve in hypertrophic cardiomyopathy: an in vitro pulsatile flow study. J Heart Valve Dis. 1995;4:422–38.

    Google Scholar 

  40. He S, Hopmeyer J, Lefebvre XP, Schwammenthal E, Yoganathan AP, Levine RA. Importance of leaflet elongation in causing systolic anterior motion of the mitral valve. J Heart Valve Dis. 1997;6:149–59.

    CAS  PubMed  Google Scholar 

  41. Sherrid MV, Gunsburg DZ, Moldenhauer S, Pearle G. Systolic anterior motion begins at low left ventricular outflow tract velocity in obstructive hypertrophic cardiomyopathy. J Am Coll Cardiol. 2000;36:1344–54.

    Article  CAS  PubMed  Google Scholar 

  42. Maron MS, Olivotto I, Zenovich AG, et al. Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. Circulation. 2006;114:2232–9.

    Article  PubMed  Google Scholar 

  43. Klues HG, Roberts WC, Maron BJ. Morphological determinants of echocardiographic patterns of mitral valve systolic anterior motion in obstructive hypertrophic cardiomyopathy. Circulation. 1993;87:1570–9.

    Article  CAS  PubMed  Google Scholar 

  44. Hoigne P, Attenhofer Jost CH, Duru F, Oechslin EN, Seifert B, Widmer U, et al. Simple criteria for differentiation of Fabry disease from amyloid heart disease and other causes of left ventricular hypertrophy. Int J Cardiol. 2006;111:413–22.

    Article  PubMed  Google Scholar 

  45. Yu EH, Omran AS, Wigle ED, Williams WG, Siu SC, Rakowski H. Mitral regurgitation in hypertrophic obstructive cardiomyopathy: relationship to obstruction and relief with myectomy. J Am Coll Cardiol. 2000;36:2219–25.

    Article  CAS  PubMed  Google Scholar 

  46. Kaple RK, Murphy RT, DiPaola LM, Houghtaling PL, Lever HM, Lytle BW, et al. Mitral valve abnormalities in hypertrophic cardiomyopathy: echocardiographic features and surgical outcomes. Ann Thorac Surg. 2008;85:1527–35. 1535.

    Article  PubMed  Google Scholar 

  47. Omoto R, Kasai C. Physics and instrumentation of Doppler color flow mapping. Echocardiography. 1987;4:467–83.

    Article  Google Scholar 

  48. Yu EH, Omran AS, Wigle ED, Williams WG, Siu SC, Rakowski H. Mitral regurgitation in hypertrophic obstructive cardiomyopathy: relationship to obstruction and relief with myectomy. J Am Coll Cardiol. 2000;36:2219–25.

    Article  CAS  PubMed  Google Scholar 

  49. Maron MS, Finley JJ, Bos JM, Hauser TH, Manning WJ, Haas TS, et al. Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy. Circulation. 2008;118:1541–9.

    Article  PubMed  Google Scholar 

  50. Oh JK, Seward JB, Jamil Tajik A. The echo manual. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 60. Print.

    Google Scholar 

  51. Maron BJ, Gottdiener JS, Arce J, et al. Dynamic subaortic obstruction in hypertrophic cardiomyopathy: analysis by pulsed Doppler echocardiography. J Am Coll Cardiol. 1985;6:1–18.

    Article  CAS  PubMed  Google Scholar 

  52. Hatle L, Angelsen B. Doppler ultrasound in cardiology. 2nd ed. Philadelphia: Lea & Febiger; 1985.

    Google Scholar 

  53. Bom K, de Boo J, Rijsterborgh H. On the aliasing problem in pulsed Doppler cardiac studies. J Clin Ultrasound. 1984;12:559–67.

    Article  CAS  PubMed  Google Scholar 

  54. Panza JA, Petrone RK, Fananapazir L, Maron BJ. Utility of continuous wave Doppler echocardiography in the noninvasive assessment of left ventricular outflow tract pressure gradient in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 1992;19(1):91–9.

    Article  CAS  PubMed  Google Scholar 

  55. Maron MS, Olivotto I, Zenovich AG, et al. Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outfl ow tract obstruction. Circulation. 2006;114:2232–9.

    Article  PubMed  Google Scholar 

  56. Shah JS, Esteban MT, Thaman R, Sharma R, Mist B, Pantazis A, Ward D, Kohli SK, Page SP, Demetrescu C, Sevdalis E, Keren A, Pellerin D, McKenna WJ, Elliott PM. Prevalence of exercise-induced left ventricular outflow tract obstruction in symptomatic patients with non-obstructive hypertrophic cardiomyopathy. Heart. 2008;94:1288–94.

    Article  CAS  PubMed  Google Scholar 

  57. Briguori C, Betocchi S, Losi MA, et al. Noninvasive evaluation of left ventricular diastolic function in hypertrophic cardiomyopathy. Am J Cardiol. 1998;81:180–7.

    Article  CAS  PubMed  Google Scholar 

  58. Maron BJ, Spirito P, Green KJ, Wesley YE, Bonow RO, Arce J. Noninvasive assessment of left ventricular diastolic function by pulsed Doppler echocardiography in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 1987;10:733–42.

    Article  CAS  PubMed  Google Scholar 

  59. Nishimura RA, Appleton CP, Redfield MM, Ilstrup DM, Holmes Jr DR, Tajik AJ. Noninvasive Doppler echocardiographic evaluation of left ventricular filling pressures in patients with cardiomyopathies: a simultaneous Doppler echocardiographic and cardiac catheterization study. J Am Coll Cardiol. 1996;28:1226–33.

    Article  CAS  PubMed  Google Scholar 

  60. Geske JB, Sorajja P, Nishimura RA, Ommen SR. Evaluation of left ventricular filling pressures by Doppler echocardiography in patients with hypertrophic cardiomyopathy: correlation with direct left atrial pressure measurement at cardiac catheterization. Circulation. 2007;116:2702–8.

    Article  PubMed  Google Scholar 

  61. Matsumura Y, Elliott PM, Virdee MS, Sorajja P, Doi Y, McKenna WJ. Left ventricular diastolic function assessed using Doppler tissue imaging in patients with hypertrophic cardiomyopathy: relation to symptoms and exercise capacity. Heart. 2002;87:247–51.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  62. McMahon CJ, Nagueh SF, Pignatelli RH, et al. Characterization of left ventricular diastolic function by tissue Doppler imaging and clinical status in children with hypertrophic cardiomyopathy. Circulation. 2004;109:1756–62.

    Article  PubMed  Google Scholar 

  63. Ho CY, Solomon SD. A clinician’s guide to tissue Doppler imaging. Circulation. 2006;113:e396–8.

    Article  PubMed  Google Scholar 

  64. Vinereanu D, Florescu N, Sculthorpe N, Tweddel AC, Stephens MR, Fraser AG. Differentiation between pathologic and physiologic left ventricular hypertrophy by tissue Doppler assessment of long-axis function in patients with hypertrophic cardiomyopathy or systemic hypertension and in athletes. Am J Cardiol. 2001;88:53–8.

    Article  CAS  PubMed  Google Scholar 

  65. Bayrak F, Kahveci G, Mutlu B, Sonmez K, Degertekin M. Tissue Doppler imaging to predict clinical course of patients with hypertrophic cardiomyopathy. Eur J Echocardiogr. 2008;9:278–83.

    Article  PubMed  Google Scholar 

  66. Yang H, Sun JP, Lever HM, Popovic ZB, Drinko JK, Greenberg NL, et al. Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy. J Am Soc Echocardiogr. 2003;16:233–9.

    Article  PubMed  Google Scholar 

  67. Carasso S, Yang H, Woo A, Vannan MA, Jamorski M, Wigle ED, et al. Systolic myocardial mechanics in hypertrophic cardiomyopathy: novel concepts and implications for clinical status. J Am Soc Echocardiogr. 2008;21:675–83.

    Article  PubMed  Google Scholar 

  68. Van Dalen BM, Kauer F, Soliman OI, Vletter WB, Michels M, ten Cate FJ, et al. Influence of the pattern of hypertrophy on left ventricular twist in hypertrophic cardiomyopathy. Heart. 2009;95:657–61.

    Article  PubMed  Google Scholar 

  69. Popovic ZB, Kwon DH, Mishra M, et al. Association between regional ventricular function and myocardial fibrosis in hypertrophic cardiomyopathy assessed by speckle tracking echocardiography and delayed hyperenhancement magnetic resonance imaging. J Am Soc Echocardiogr. 2008;21:1299–305.

    Article  PubMed  Google Scholar 

  70. Nishimura RA, Ommen SR. Hypertrophic cardiomyopathy: the search for obstruction. Circulation. 2006;114:2200–2.

    Article  PubMed  Google Scholar 

  71. Okeie K, Shimizu M, Yoshio H, Ino H, Yamaguchi M, Matsuyama T, Mabuchi H. Left ventricular systolic dysfunction during exercise and dobutamine stress in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol. 2000;36(3):856–63.

    Article  CAS  PubMed  Google Scholar 

  72. Pellikka PA, Oh JK, Bailey KR, Nichols BA, Monahan KH, Tajik AJ. Dynamic intraventricular obstruction during dobutamine stress echocardiography. A new observation. Circulation. 1992;86(5):1429–32.

    Article  CAS  PubMed  Google Scholar 

  73. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Thorac Cardiovasc Surg. 2011;142:1303–8.

    Article  PubMed  Google Scholar 

  74. Kawano S, Iida K, Fujieda K, Yukisada K, Magdi ES, Iwasaki Y, Sugishita Y. Response to isoproterenol as a prognostic indicator of evolution from hypertrophic cardiomyopathy to a phase resembling dilated cardiomyopathy. J Am Coll Cardiol. 1995;25(3):687–92.

    Article  CAS  PubMed  Google Scholar 

  75. Marwick TH, Nakatani S, Haluska B, Thomas JD, Lever HM. Provocation of latent left ventricular outflow tract gradients with amyl nitrite and exercise in hypertrophic cardiomyopathy. Am J Cardiol. 1995;75(12):805–9.

    Article  CAS  PubMed  Google Scholar 

  76. Maron MS, Olivotto I, Zenovich AG, Link MS, Pandian NG, Kuvin JT, Nistri S, Cecchi F, Udelson JE, Maron BJ. Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract obstruction. Circulation. 2006;114:2232–9.

    Article  PubMed  Google Scholar 

  77. Schwammenthal E, Schwartzkopff B, Block M, Johns J, Lösse B, Engberding R, Breithardt G. Doppler echocardiographic assessment of the pressure gradient during bicycle ergometry in hypertrophic cardiomyopathy. Am J Cardiol. 1992;69(19):1623–8.

    Article  CAS  PubMed  Google Scholar 

  78. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, Naidu SS, Nishimura RA, Ommen SR, Rakowski H, Seidman CE, Towbin JA, Udelson JE, Yancy CW. 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Thorac Cardiovasc Surg. 2011;142:1303–8.

    Article  PubMed  Google Scholar 

  79. Argulian E, Chaudhry FA. Stress testing in patients with hypertrophic cardiomyopathy. Prog Cardiovasc Dis. 2012;54:477–82.

    Article  PubMed  Google Scholar 

  80. Nagueh SF, Lakkis NM, He ZX, Middleton KJ, Killip D, Zoghbi WA, Quiñones MA, Roberts R, Verani MS, Kleiman NS, Spencer III WH. Role of myocardial contrast echocardiography during nonsurgical septal reduction therapy for hypertrophic obstructive cardiomyopathy. J Am Coll Cardiol. 1998;32:225–9.

    Article  CAS  PubMed  Google Scholar 

  81. Sigwart U. Non-surgical myocardial reduction for hypertrophic obstructive cardiomyopathy. Lancet. 1995;346:211–4.

    Article  CAS  PubMed  Google Scholar 

  82. Alam M, Dokainish H, Lakkis N. Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a systematic review of published studies. J Interv Cardiol. 2006;19:319–27.

    Article  PubMed  Google Scholar 

  83. Teis A, Sheppard MN, Alpendurada F. Subaortic membrane: correlation of imaging with pathology. Eur Heart J. 2010;31:2822.

    Article  PubMed  Google Scholar 

  84. Rahman JE, Helou EF, Gelzer-Bell R, Thompson RE, Kuo C, Rodriguez ER, et al. Noninvasive diagnosis of biopsy-proven cardiac amyloidosis. J Am Coll Cardiol. 2004;43(3):410–5.

    Article  PubMed  Google Scholar 

  85. Badano L, Fox K, Sicari R, Zamorano JL. Disease with a main influence on myocardial tissue damage. In: EAE textbook of echocardiography. 1st ed. Oxford (UK): Oxford Medical Press; 2011. p. 335–6.

    Google Scholar 

  86. Phelan D, Collier P, Thavendiranathan P, Popovic ZB, Hanna M, Plana JC, et al. Relative ‘apical sparing’ of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis. Heart. 2012;98(19):1442–8.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Winthrop University Hospital, 120 Mineola Blvd, Suite 500, Mineola, NY, 11501, USA

    Beevash Ray MD

  2. Sports Cardiology and Hypertrophic Cardiomyopathy Program, Division of Cardiology, Department of Medicine, Lehigh Valley Health Network, 1250 S Cedar Crest Blvd, Suite 300, Allentown, PA, 18103, USA

    Matthew W. Martinez MD, FACC

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Correspondence to Matthew W. Martinez MD, FACC .

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  1. Winthrop University Hospital, Mineola, New York, USA

    Srihari S. Naidu

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Ray, B., Martinez, M.W. (2015). Approach to Diagnosis: Echocardiography. In: Naidu, S. (eds) Hypertrophic Cardiomyopathy. Springer, London. https://doi.org/10.1007/978-1-4471-4956-9_4

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