Effect of Soyasaponin on Expression of Fas/FasL of Pneumonocyte in Silicotic Fibrosis Rats
Objectives to discuss the effect of SS on expression of Fas and FasL of Pneumonocyte in the Silicotic Fibrosis Rats. Methods Superoxide dismutase (SOD) and malondialdehyde (MDA) of pulmonary tissue and changes of that after SS intervened were observed. The immunohistochemical method was used to detect the level in the expressions of Fas and FasL protein. Results Compared with NS group, the level of SOD decreased constantly in SiO2 group (P < 0.05). MDA was increased significantly and maintain the high level (P < 0.05). Expression of Fas protein of SiO2 group was 4.51 and 5.05 times compared with its NS group. Its positive staining was located in epithelial cells of bronchi-duct and alveolar endothelial cells. Conclusions Fas and FasL system might take part in the pulmonary fibrosis. A certain dose of SS might down regulate the expressions of Fas and FasL to relieve the development of pulmonary fibrosis.
KeywordsSilicosis Pulmonary fibrosis Soyasaponin Fas FasL
Hebei Province Key Labo- ratory of Occupational Health and safety for Coal Industry, Hebei United Univeristy, Tangshan Hebei Province, China, 063000. Science and technology research and development program of Tangshan City. (Grant No.10150 204A-36).
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