Intraepidermal Neoplasia

  • Robert A. Norman
  • Edward M. YoungJr


Bowen’s disease is a squamous cell carcinoma-in-situ. Paget’s disease and extramammary Paget’s disease are adenocarcinomas-in-situ.


Adenocarcinoma Arsenic Psoriasis Papilloma Toluidine 


  1. 1.
    Callen JP, Headington J. Bowen’s and non-Bowen’s squamous intraepidermal neoplasia or the skin. Arch Dermatol. 1980;116:422.PubMedCrossRefGoogle Scholar
  2. 2.
    Graham JH, Helwig EB. Bowen’s disease and its relationship to systemic cancer. Arch Dermatol. 1959;80:133.CrossRefGoogle Scholar
  3. 3.
    Arbesman H, Ransoholl DF. Is Bowen’s disease a prediction for the development of internal malignancy? JAMA. 1987;257:516.PubMedCrossRefGoogle Scholar
  4. 4.
    Chuang TY, Reimer GT. Bowen’s disease and internal malignancy: a matched case–control study. J Am Acad Dermatol. 1988;19:47.PubMedCrossRefGoogle Scholar
  5. 5.
    Marshberg A. Re-evaluation of toluidine blue application as a diagnostic adjunct in the detection of asymptomatic oral squamous carcinoma: a continuing perspective of oral cancer. Cancer. 1980;46:758.CrossRefGoogle Scholar
  6. 6.
    Selden ST. Toluidine blue stain for atypical cells (correspondence). J Am Acad Dermatol. 1986;14:517.PubMedCrossRefGoogle Scholar
  7. 7.
    Ahmed I, Berth-Jones J, Charles-Holmes S, et al. Comparison of cryotherapy with curettage in the treatment of Bowen’s disease: a prospective study. Br J Dermatol. 2000;143:759–66.PubMedCrossRefGoogle Scholar
  8. 8.
    Patel GK, Goodwin R, Chawla M, et al. Imiquimod 5% cream monotherapy for cutaneous squamous cell carcinoma in situ (Bowen’s disease): a randomized, double-blind, placebo-controlled trial. J Am Acad Dermatol. 2006;54:1025–32.PubMedCrossRefGoogle Scholar
  9. 9.
    Morton CA, Horn M, Leman J, et al. A randomized, placebo-controlled, European study comparing MAL-PDT with cryotherapy and 5-fluorouracil in subjects with Bowen’s disease. J Eur Acad Dermatol Venereol. 2004;18 Suppl 2:415.Google Scholar
  10. 10.
    Cox NH, Eedy DJ, Morton CA. Guidelines for management of Bowen’s disease: 2006 update. Br J Dermatol. 2007;156:11–21.PubMedCrossRefGoogle Scholar
  11. 11.
    Bell HK, Rhodes LE. Bowen’s disease – a retrospective review of clinical management. Clin Exp Dermatol. 1999;24:338–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Marcus E. The management of Paget’s disease of the breast. Curr Treat Options Oncol. 2004;5:153–60.PubMedCrossRefGoogle Scholar
  13. 13.
    Paget J. On disease of the mammary areola preceding cancer of the mammary gland. St Bartholemew Hosp Res Lond. 1874;10:87–9.Google Scholar
  14. 14.
    Fishman DA, Chambers SK, Schwartz PE, Kohorn EI, Chambers JT. Extramammary Paget’s disease of the vulva. Gynecol Oncol. 1995;56:266–70.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  • Robert A. Norman
    • 1
  • Edward M. YoungJr
    • 2
  1. 1.Dermatology HealthcareTampaUSA
  2. 2.TarzanaUSA

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