Vulvar Dysplasia and Neoplasia

  • Kasia Szyfelbein Masterpol
  • Andrea Primiani
  • Lyn McDivitt Duncan


The differential diagnosis of abnormalities of the vulvar epithelium includes inflammatory diseases and changes caused by infection with human papilloma virus (HPV). Condyloma is the most common discrete lesion caused by HPV, the changes may be subtle and resemble seborrheic keratosis or there may be extensive koilocytosis. There is significant histological overlap between dysplasia associated with inflammatory processes such as lichen planus or lichen sclerosus and HPV associated dysplasia. The separation of these processes into classic/bowenoid and simplex/differentiated vulvar intraepidermal neoplasia (VIN) provides a framework for differential diagnosis.


Public Health Differential Diagnosis Inflammatory Disease Inflammatory Process Human Papilloma Virus 
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Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Kasia Szyfelbein Masterpol
    • 1
  • Andrea Primiani
    • 2
  • Lyn McDivitt Duncan
    • 3
  1. 1.Department of DermatologyBoston Medical CenterBostonUSA
  2. 2.Massachusetts General Hospital WRN2, Pathology ServiceBostonUSA
  3. 3.Massachusetts General Hospital WRN825, Dermatopathology UnitBostonUSA

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