Research Pipeline I: Topical Therapies

  • Bassel Mahmoud
  • Linda Stein Gold


Psoriasis is a common chronic inflammatory skin disease affected by both genetics and immune factors. This devastating disease has a huge impact on the quality of life of affected individuals and a pronounced economic burden on the society. Recent understanding of the immunopathogenesis of psoriasis has led to significant progress in its treatment. Many disease-related factors affect the choice of therapy. Mild psoriasis can generally be managed with topical medications, while moderate-to-severe psoriasis is conventionally treated with more aggressive systemic therapies. The ideal treatment should be cost-effective, provide long-term remission and exhibit few side effects. This chapter highlights topical therapies currently under development for psoriasis.


Psoriasis Topical Pipeline AN2728 INCB18424 JAK kinase inhibitor Methotrexate 


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Copyright information

© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Department of DermatologyHenry Ford HospitalDetroitUSA

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