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Antifibrinolytic Therapy in Pediatric Congenital Heart Surgery

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Inflammatory Response in Cardiovascular Surgery

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Abstract

For decades, aprotinin was the standard antifibrinolytic drug used in adult and pediatric major surgery [1]. Numerous studies showed that the perioperative loss of blood, and thus the use of homologous blood, could be limited by administering aprotinin. Other antifibrinolytic-acting substances, such as e-aminocapronic acid (EACA) or tranexamic acid (TXA), tended to be misfits in routine clinical practice.

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Authors and Affiliations

  1. Department for Pediatric Anesthesiology, German Pediatric Heart Center, Asklepios Klinik Sankt Augustin, Arnold-Janssenstr. 29, Sankt Augustin, 53737, Germany

    Ehrenfried Schindler

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  1. Ehrenfried Schindler
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Correspondence to Ehrenfried Schindler .

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  1. University Nove de Julho, Melo Alves 685, São Paulo, 01417-010, São Paulo, Brazil

    Edmo Atique Gabriel

  2. Pontifícia Universidade Católica de Camp, Rodovia D. Pedro I, km 136, São Paulo, 13086-900, São Paulo, Brazil

    Sthefano Atique Gabriel

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Schindler, E. (2013). Antifibrinolytic Therapy in Pediatric Congenital Heart Surgery. In: Gabriel, E., Gabriel, S. (eds) Inflammatory Response in Cardiovascular Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4429-8_40

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  • DOI: https://doi.org/10.1007/978-1-4471-4429-8_40

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