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Metalloproteinases in Acute Venous Occlusion

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Inflammatory Response in Cardiovascular Surgery

Abstract

Acute venous thrombosis is a life-threatening event proceeding from altered blood flow, abnormalities in the vessel wall, and changes in blood components (Virchow’s triad). Aberrations in the coagulatory and fibrinolytic pathways contribute to the altered blood components, but other blood proteases also have roles to play.

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Abbreviations

AP:

Antiplasmin

AT:

Antithrombin

col:

Collagen

DVT:

Deep vein thrombosis

ECM:

Extracellular matrix

F:

Factor

GF:

Growth factor

IFN:

Interferon

IL:

Interleukin

LDL:

Low density lipoprotein

LPS:

Lipopolysaccharide

LRP:

Low density lipoprotein receptor-related protein

MG:

Macroglobulin

MMP:

Matrix metalloproteinase

PAI:

Plasminogen activator inhibitor

PDGF:

Platelet-derived growth factor

ROS:

Reactive oxygen species

TF:

Tissue factor

TFPI:

Tissue factor pathway inhibitor

TGF:

Transforming growth factor

TIMP:

Tissue inhibitor of metalloproteinase

TLR:

Toll-like receptor

TM:

Thrombomodulin

TNF:

Tissue necrosis factor

tPA:

Tissue plasminogen activator

uPA:

Urokinase plasminogen activator

vWF:

von Willebrand factor

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Authors and Affiliations

  1. Department of Cardiovascular Surgery, Bristol Heart Institute, 7th Floor, Queens Building, Bristol Royal Infirmary, Bristol, BS2 8HW, UK

    Anita C. Thomas PhD

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  1. Anita C. Thomas PhD
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Correspondence to Anita C. Thomas PhD .

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Editors and Affiliations

  1. University Nove de Julho, Melo Alves 685, São Paulo, 01417-010, São Paulo, Brazil

    Edmo Atique Gabriel

  2. Pontifícia Universidade Católica de Camp, Rodovia D. Pedro I, km 136, São Paulo, 13086-900, São Paulo, Brazil

    Sthefano Atique Gabriel

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Thomas, A.C. (2013). Metalloproteinases in Acute Venous Occlusion. In: Gabriel, E., Gabriel, S. (eds) Inflammatory Response in Cardiovascular Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4429-8_19

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  • DOI: https://doi.org/10.1007/978-1-4471-4429-8_19

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