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Engineering Nanomaterials for Biosensors and Therapeutics

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Engineering in Translational Medicine

Abstract

Nanomaterials have attracted lots of recent research attention as they possess unique photophysical, magnetic, and thermal properties with the potential of being engineered for various biomedical theranostic applications. The objective of this book chapter is to provide a timely overview on the synthetic methodology, surface engineering, physiological itinerary, and theranostic applications for the nanophases and nanostructures consisting of inorganic and/or organic materials. This chapter starts with an introduction, followed by a brief review of the applications and preparative methods of the inorganic nanomaterials with surface plasmon resonance, photoluminescence, magnetic, and bioactive properties. The effects of surface modification with polymers and morphology on the physiological itinerary and toxicity of the nanomaterials are then discussed to help the design of vehicles for targeted tissue imaging and drug delivery. Finally, examples of several promising nanotechnologies and theranostic applications are given including biosensors, magnetic hyperthermia, and photodynamic therapy (PDT) for tumor treatment. This chapter ends with a conclusion and future perspective section. To make use of all the innovative ideas and demonstrative prove-of-principles of nanomaterials for practical biomedical applications, it is absolutely necessary to emphasize and expand efforts on their translational research and development, including clinical studies and large-scale manufacturing of these novel engineered nanomaterials.

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Acknowledgments

We would like to thank the National Science Council (grant no. NSC 101-2627-E-010-001 and NSC 101-2113-M-010-002-MY2) and the Ministry of Education of Taiwan for financial support of the integrated research in the nanotechnology and biomedical science and engineering areas.

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Authors and Affiliations

  1. Department of Biomedical Engineering, National Yang Ming University, 7923, No. 155, Sec. 2, Li-Nong Street, Taipei, 112, Taiwan, ROC

    Tse-Ying Liu

  2. Department of Biomedical Engineering, National Yang Ming University, 7914, No. 155, Sec. 2, Li-Nong Street, Taipei, 112, Taiwan, ROC

    Chun-Liang Lo

  3. Institute of Biophotonics, National Yang Ming University, 7959, No. 155, Sec. 2, Li-Nong Street, Taipei, 112, Taiwan, ROC

    Chih-Chia Huang

  4. Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming University, 5540, No. 155, Sec. 2, Li-Nong Street, Taipei, 112, Taiwan, ROC

    Syue-Liang Lin

  5. Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, 7199, No. 155, Sec. 2, Li-Nong Street, Taipei, 112, Taiwan, ROC

    C. Allen Chang

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  1. Tse-Ying Liu
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Correspondence to C. Allen Chang .

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  1. Dept of Radiology/Medical Physics/Biomed, University of Wisconsin, Madison, USA

    Weibo Cai

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Liu, TY., Lo, CL., Huang, CC., Lin, SL., Chang, C.A. (2014). Engineering Nanomaterials for Biosensors and Therapeutics. In: Cai, W. (eds) Engineering in Translational Medicine. Springer, London. https://doi.org/10.1007/978-1-4471-4372-7_19

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  • DOI: https://doi.org/10.1007/978-1-4471-4372-7_19

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