Methodological Issues



Outline: In this chapter we provide information about different ways to process heart rate variability indices. We explain their mathematical background, provide their algorithms, and discuss their general relevance. In the second part we discuss standard test demands like validity and reliability. In the third part we discuss different physiological, pathophysiological, and pharmacological confounding factors that may have an impact on HRV calculations.


Heart Rate Variability Detrended Fluctuation Analysis Holter Monitoring Recurrence Plot Heart Rate Variability Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Abhishekh HA, Nisarga P, Kisan R, Meghana A, Chandran S, Trichur R, Sathyaprabha TN. Influence of age and gender on autonomic regulation of heart. J Clin Monit Comput. 2013;27:259–64.PubMedGoogle Scholar
  2. Aboy M, Crespo C, McNames J, Bassale J, Jenkins L, Goldstein B. A biomedical signal processing toolbox. Brno: Biosignal; 2002.Google Scholar
  3. Acharya UR, Kannathal N, Sing OW, Ping LY, Chua T. Heart rate analysis in normal subjects of various age groups. BioMed Eng Online. 2004;3:24. Free at:
  4. Adamopoulos S, Piepoli M, McCance A, Bernardi L, Rocadaelli A, Ormerod O, Forfar C, Sleight P, Coats AJ. Comparison of different methods for assessing sympathovagal balance in chronic congestive heart failure secondary to coronary artery disease. Am J Cardiol 1992;70:1576–82.Google Scholar
  5. Adamopoulos S, Ponokowski P, Cerquetani E, Piepoli M, Rosano G, Ssleight P, Coats AJ. Circadian pattern of heart rate variability in chronic heart failure patients. Effects of physical training. Eur Heart J. 1995;16:1308–10.Google Scholar
  6. Ahmad S, Tejuja A, Newman KD, Zarychanski R, Seely AJ. Clinical review: a review and analysis of heart rate variability and the diagnosis and prognosis of infection. Crit Care. 2009a;13:232.PubMedGoogle Scholar
  7. Ahmad S, Ramsay T, Huebsch L, Flanagan S, McDiarmid S, Batkin I, McIntyre L, Sundaresan SR, Maziak DE, Shamji FM, Hebert P, Fergusson D, Tinmouth A, Seely AJ. Continuous multi-parameter heart rate variability analysis heralds onset of sepsis in adults. PLoS One. 2009b;4(8):e6642.PubMedGoogle Scholar
  8. Akselrod S, Gordon D, Ubel FA, Shannon DC, Barger AC, Cohen RJ. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat to beat cardiovascular control. Science. 1981;213:220–2.PubMedGoogle Scholar
  9. Althaus M, Mulder LJM, Mulder G, van Roon AM, Minderaa RB. Influence of respiratory activity on the cardiac response pattern to mental effort. Psychophysiology. 1998;35:420–30.PubMedGoogle Scholar
  10. Ambarish V, Barde P, Vyas A, Deepakk KK. Comparison between pre-prandial and post-prandial heart rate variability (HRV). Indian J Physiol Pharmacol. 2005;49:436–42.PubMedGoogle Scholar
  11. Ashkenazy YC, Lewkowicz M, Levitan J, Havlin J, Saermark K, Moelgaard H, Bloch Thomsen PE. Discrimination between healthy and sick cardiac autonomic system by detrended heart rate variability analysis. ArXiv:chao-dyn/9810008 v2. 1998.Google Scholar
  12. Ashkenazy Y, Lewkowicz M, Levitan J, Havlin S, Saermark K, Moelgaard H, Bloch Thomsen PE, Moller M, Hintze U, Huikuri HV. Scale specific and scale independent measures of heart rate variability as risk indicators. ArXiv: Physics/ 9909029 v2. 2000.Google Scholar
  13. Backs RW, Seljos KA. Metabolic and cardiorespiratory measures of mental effort: the effects of level of difficulty in a working memory task. Int J Psychophysiol. 1994;16:57–68.PubMedGoogle Scholar
  14. Bär KJ, Greiner W, Jochum T, Friedrich M, Wagner G, Sauer H. The influence of major depression and its treatment on heart rate variability and pupillary light reflex parameters. J Affect Disord. 2004;82:245–52.PubMedGoogle Scholar
  15. Bär KJ, Koschke M, Berger S, Schulz S, Tancer M, Voss A, Yeragani VK. Influence of olanzapine on QT-variability and complexity measures of heart rate in patients with schizophrenia. J Clin Psychopharmacol. 2008;28:694–8.PubMedGoogle Scholar
  16. Barclay JL, Miller BG, Dick S, Dennekamp M, Ford I, Hillis GS, Ayres JG, Seaton A. A panel study of air pollution in subjects with heart failure; negative results in treated patients. Occup Environ Med. 2009;66:325–34.PubMedGoogle Scholar
  17. Barthel P, Schneider R, Bauer A, Ulm K, Schmitt C, Schömig A, Schmidt G. Risk stratification after acute myocardial infraction by heart rate turbulences. Circulation. 2003;108:1221–6.PubMedGoogle Scholar
  18. Bassingthwaighte JB, Raymond GM. Evaluation of the dispersional analysis method for fractal time series. Ann Biomed Eng. 1995;23:491–505.PubMedGoogle Scholar
  19. Batchinsky AI, Cooke WH, Kuusela T, Cancio LC. Loss of complexity characterizes the heart rate response to experimental hemorrhagic shock in swine. Crit Care Med. 2007a;35:656–8.Google Scholar
  20. Batchinsky AI, Cancio LC, Salinas J, Kuusela T, Cooke WH, Wang JJ, Boehme M, Convertino VA, Holcomb JB. Prehospital loss of R-to-R interval complexity is associated with mortality in trauma patients. J Trauma. 2007b;63:512–8.PubMedGoogle Scholar
  21. Bauer A, Malik M, Schmidt G, Barthel P, Bonnemeier H, Cygankiewicz I, Guzik P, Lombardi F, Müller A, Oto A, Schneider R, Watanabe M, Wichterle D, Zareba W. Heart rate turbulence: standards of measurement, physiological interpretation, and clinical use: international Society for Holter and Noninvasive Electrophysiology Consensus. J Am Coll Cardiol. 2008;52:1353–65.PubMedGoogle Scholar
  22. Beaumont A, Marmarou A. Approximate entropy: a regular statistic for assessment of intracranial pressure. Acta Neurochir Suppl. 2002;81:193–5.PubMedGoogle Scholar
  23. Bédard ME, Marquis K, Poirier P, Provencher S. Reduced heart rate variability in patients with chronic obstructive pulmonary disease independent of anticholinergic or β-agonist medications. COPD. 2010;7:391–7.PubMedGoogle Scholar
  24. Berntson GG, Cacioppo JT. Heart rate variability: a neuroscientific perspective for further studies. Card Electrophysiol Rev. 1999;3:279–82.Google Scholar
  25. Berntson GG, Cacioppo JT. Heart rate variability: stress and psychiatric conditions. In: Malik M, Camm AJ, editors. Dynamic electrocardiography. New York: Futura; 2004. p. 57–64.Google Scholar
  26. Berntson GG, Cacioppo JT, Binkley PF, Uchino BN, Quigley KS, Fieldstone A. Autonomic cardiac control: III. Psychological stress and cardiac response in autonomic spaces as revealed by pharmacological blockades. Psychophysiology. 1994;31:599–608.PubMedGoogle Scholar
  27. Berntson GG, Cacioppo JT, Fieldstone A. Illusions, arithmetic, and the bidirectional modulation of vagal control of the heart. Biol Psychol. 1996;44:1–17.PubMedGoogle Scholar
  28. Berntson GG, Bigger Jr JT, Eckberg DL, Grossman P, Kaufmann PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, van der Molen MW. Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology. 1997;34:623–48.PubMedGoogle Scholar
  29. Bigger JT, Fleiss JL, Rolnitzky LM, Steinman RC. The ability of several short time measures of RR variability to predict mortality after myocardial infarction. Circulation. 1993;88:927–34.PubMedGoogle Scholar
  30. Bigger JT, Fleiss JL, Steinman RC, Rolnitzky LM, Schneider WJ, Stein PK. RR variability in healthy, middle-aged persons compared with patients with chronic coronary heart disease or recent acute myocardial infarction. Circulation. 1995;91:1936–43.PubMedGoogle Scholar
  31. Bigger JT, Steinman RC, Rolnitzky LM, Fleiss JL, Albrecht P, Cohen RJ. Power law behaviour of RR-interval variability in healthy middle-aged persons, patients with recent acute myocardial infarction and patients with heart transplants. Circulation. 1996;15:2142–52.Google Scholar
  32. Binckley PF, Haas GJ, Starling RC, Nunziata E, Hatton PA, Leier CV, Cody RJ. Sustained augmentation of parasympathetic tone with angiotensin-converting enzyme inhibition in patients with congestive heart failure. J Am Coll Cardiol. 1993;21:655–61.Google Scholar
  33. Bonaduce D, Marciano F, Petretta M, Migaux ML, Morgano G, Bianchi V, Salemme L, Valva G, Condorelli M. Effects of converting enzyme inhibition on heart period variability in patients with acute myocardial infarction. Circulation. 1994;90:108–13.PubMedGoogle Scholar
  34. Bonnemeier H, Richardt G, Potratz J, Wiegand UK, Brandes A, Kluge N, Katus HA. Circadian profile of cardiac autonomic nervous modulation in healthy subjects: differing effects of aging and gender on heart rate variability. J Cardiovasc Electrophysiol. 2003a;14:791–9.PubMedGoogle Scholar
  35. Bonnemeier H, Wiegand UK, Friedlbinder J, Schulenburg S, Hartmann F, Bode F, Katus HA, Richardt G. Reflex cardiac activity in ischemia and reperfusion: heart rate turbulence in patients undergoing direct percutaneous coronary intervention for acute myocardial infarction. Circulation. 2003b;108:958–64.PubMedGoogle Scholar
  36. Bornas X, Llabrés J, Tortella-Feliu M, Fullana MA, Montoya P, López A, Noguera M, Gelabert JM. Vagally mediated heart rate variability and heart rate entropy as predictors of treatment outcome in flight phobia. Biol Psychol. 2007;76:188–95.PubMedGoogle Scholar
  37. Boucsein W, Backs RW, editors. Engineering psychophysiology: issues and applications. London: Lawrence Erlbaum; 2000.Google Scholar
  38. Bravi A, Longtin A, Seely AJ. Review and classification of variability analysis techniques with clinical applications. Biomed Eng Online. 2011;10:90.PubMedGoogle Scholar
  39. Bravi A, Green G, Longtin A, Seely AJ. Monitoring and identification of sepsis development through a composite measure of heart rate variability. PLoS One. 2012;7(9):e45666.PubMedGoogle Scholar
  40. Brown TE, Beightol LA, Koh J, Eckberg DL. Important influences of respiration on human R-R interval power spectra is largely ignored. J Appl Physiol. 1993;75:2310–7.PubMedGoogle Scholar
  41. Burr RL, Motzer SA, Chen W, Cowan MJ, Shulman RJ, Heitkemper MM. Heart rate variability and 24-hour minimum heart rate. Biol Res Nurs. 2006;7:256–67.PubMedGoogle Scholar
  42. Busek P, Vankova J, Opavsky J, Salinger J, Nevsimalova S. Spectral analysis of heart rate variability in sleep. Physiol Res. 2005;54:369–76.PubMedGoogle Scholar
  43. Cacioppo JT. Social neuroscience: autonomic, neuroendocrine, and immune responses to stress. Psychophysiology. 1994;31:113–28.PubMedGoogle Scholar
  44. Carnethon MR, Prineas RJ, Temprosa M, Zhang ZM, Uwaifo G, Molitch ME, Diabetes Prevention Program Research Group. The association among autonomic nervous system function, incident diabetes, and intervention arm in the Diabetes Prevention Program. Diabetes Care. 2006;29:914–9.PubMedGoogle Scholar
  45. Carney RM, Freedland KE, Veith RC. Depression, the autonomic nervous system and coronary heart disease. Psychosom Med. 2005a;67 Suppl 1:S29–33.PubMedGoogle Scholar
  46. Carney RM, Blumenthal JA, Freedland KE, Stein PK, Howells WB, Berkman LF, Watkins LL, Czaikowski SM, Hayano J, Domitrovich PP, Jaffe AS. Low heart rate variability and the effect of depression on post-myocardial infarction morbidity. Arch Intern Med. 2005b;165:1486–91.PubMedGoogle Scholar
  47. Cashion AK, Cowan PA, Milstead EJ, Gaber AO, Hathaway DK. Heart rate variability, mortality, and exercise in patients with end-stage real disease. Prog Transplant. 2000;10:10–6.PubMedGoogle Scholar
  48. Chen PS, Tan AY. Autonomic nerve activity and atrial fibrillation. Heart Rhythm. 2007;4(Suppl):S61–4.PubMedGoogle Scholar
  49. Chen W, Zhuang J, Yu W, Wang Z. Measuring complexity using FuzzyEn, ApEn, and SampEn. Med Eng Phys. 2009;31:61–8.PubMedGoogle Scholar
  50. Choi JB, Hong S, Nelesen R, Bardwell WA, Natarajan L, Schubert C, Dimsdale JE. Age and ethnicity differences in short-term heart-rate variability. Psychosom Med. 2006;68:421–6.PubMedGoogle Scholar
  51. Chowdhary S, Osman F, Ng G, Vaile J, Townend J. Effects of quinalapril and candesartan on heart rate turbulence in heart failure (abstr). Pacing Clin Electrophysiol. 2000;23:643 [Quoted after Bauer 2008].Google Scholar
  52. Chung MH, Kuo TB, Hsu N, Chu H, Chou KR, Yang CC. Sleep and autonomic nervous system changes – enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses. Scand J Work Environ Health. 2009;35:180–7.PubMedGoogle Scholar
  53. Colosimo A, Giuliani A, Mancini AM, Piccirillo G, Marigliano V. Estimating a cardiac age by means of heart rate variability. Am J Physiol. 1997;273:H1841–7.PubMedGoogle Scholar
  54. Contrada DJ, Del BA, Levy L, Weiß T. Form and magnitude of betasympathetic and parasympathetic influences on pulse transit time. Psychophysiology. 1995;32:329–34.PubMedGoogle Scholar
  55. Costa MD, Peng CK, Goldberger AL. Multiscale analysis of heart rate dynamics: entropy and time irreversibility measures. Cardiovasc Eng. 2008;8:88–93.PubMedGoogle Scholar
  56. Cygankiewicz I, Wranicz JK, Bolinska H, Zaslonka J, Zareba W. Relationship between heart rate turbulence and heart rate, heart rate variability, and number of ventricular premature beats in coronary patients. J Cardiovasc Electrophysiol. 2004;15:731–7.PubMedGoogle Scholar
  57. Da Fontoura Costa L, Caldeiro de Melo R, da Silva E, Borghi-Silva A, Catai AM. Spectral detrended fluctuation analysis and its application to heart rate variability assessment. ArXiv: q-bio.QM/0507016v1. 2005.Google Scholar
  58. Danev S, Nikolova R, Kerekovska M, Svetoslavov S. Relationship between heart rate variability and hypercholerolaemia. Cent Eur J Public Health. 1997;5:143–6.PubMedGoogle Scholar
  59. Das M, Gebber GL, Barman SM, Lewis CD. Fractal properties of sympathetic nerve discharge. J Neurophysiol. 2003;89:833–40.PubMedGoogle Scholar
  60. Davies JI, Band M, Morris A, Struthers AD. Spironolactone impairs endothelial function and heart rate variability in patients with type 2 diabetes. Diabetologia. 2004;47:1687–94.PubMedGoogle Scholar
  61. Degangi GA, DiPietro JA, Greenspan SI, Porges SW. Psychophysiological characteristics of the regularly disordered infant. Infant Behav Dev. 1991;14:37–50.Google Scholar
  62. Delaney JP, Brodie DA. Effects of short-term psychological stress on the time and frequency domains of heart rate variability. Percept Mot Skills. 2000;91:515–24.PubMedGoogle Scholar
  63. Denver JW, Reed SF, Porges SW. Methodological issues in the quantification of respiratory sinus arrhythmia. Biol Psychol. 2007;74:286–94.PubMedGoogle Scholar
  64. Di Rienzo M, Castiglione P, Mancia G, Parati G, Pedotti A. 24 h sequential spectral analysis of arterial blood pressure and pulse interval in free-moving subjects. IEEE Trans Biomed Engl. 1989;36:1066–75.Google Scholar
  65. Diaz JO, Castellanos A, Moleiro F, Interian A, Myerburg RJ. Relation between sinus rates preceding and following ectopic beats occurring in isolation and as episodes of bigeminy in young healthy subjects. Am J Cardiol. 2002;90:332–5.PubMedGoogle Scholar
  66. DiBona GF. Sympathetic nervous system and the kidney in hypertension. Curr Opin Nephrol Hypertens. 2002;11:197–200.PubMedGoogle Scholar
  67. Dishman RK, Nakamura Y, Garcia ME, Thompson RW, Dunn AL, Blair SN. Heart rate variability, trait anxiety, and perceived stress among physically fit men and women. Int J Psychophysiol. 2000;37:121–33.PubMedGoogle Scholar
  68. Druschky A, Hilz MJ, Platsch G, Radespiegel-Tröger M, Druschky K, Kuwert T, Stefan H, Neundörfer B. Interictal cardiac autonomic dysfunction in temporal lobe epilepsy demonstrated by [123I]metaiodobenzylguanidine-SPECT. Brain. 2001;124:2372–82.PubMedGoogle Scholar
  69. Duschek S, Matthias E, Schandry R. Essential hypotension is accompanied by deficits in attention and working memory. Behav Med. 2005;30:149–58.PubMedGoogle Scholar
  70. Duschek S, Muckenthaler M, Werner N, del Paso GA. Relationships between features of autonomic cardiovascular control and cognitive performance. Biol Psychol. 2009;81:110–7.PubMedGoogle Scholar
  71. Echeverria JC, Woolfson MS, Crowe JA, Hayes-Gill BR, Croaker GDH, Vyas H. Interpretation of heart rate variability via detrended fluctuation analysis and άβ filter. ArXiv: physics/ 0306181 v1. 2003.Google Scholar
  72. Eller-Berndl D. Herzratenvariabilität. Wien: Verlagshaus der Ärzte; 2010.Google Scholar
  73. Ermis N, Gullu H, Caliskan M, Unsal A, Kulaksizoglu M, Muderrisoglu H. Gabapentin therapy improves heart rate variability in diabetic patients with peripheral neuropathy. J Diabetes Complications. 2010;24:229–33.PubMedGoogle Scholar
  74. Ernst G, Rostrup M. HRV before and after night shift of nurses. An observational study. 2013a (to be published).Google Scholar
  75. Ernst G, Rostrup M. Terminal cancer patients have marked reduced heart rate variability. An observational study. 2013b (to be published).Google Scholar
  76. Esperer HD, Esperer C, Cohen RJ. Cardiac arrhythmias imprint specific signatures on Lorenz plots. Ann Noninvasive Electrocardiol. 2008;13:44–60.PubMedGoogle Scholar
  77. Evans JM, Ziegler MG, Patwardhan AR, Ott JB, Kim CS, Leonelli FM, Knapp CF. Gender differences in autonomic cardiovascular regulation: spectral, hormonal, and hemodynamic indexes. J Appl Physiol. 2001;91:2611–8.PubMedGoogle Scholar
  78. Feneberg R, Sparber M, Veldhuis JD, Mehls O, Ritz E, Schaefer F. Altered temporal organization of plasma insulin oscillations in chronic renal failure. J Clin Endocrinol Metab. 2002;87:1965–73.PubMedGoogle Scholar
  79. Ferguson DW, Berg WJ, Sanders JS, Roach PJ, Kempf JS, Kienzle MG. Sympathoinhibitory responses to digitalis glycosides in heart failure patients. Direct evidence from sympathetic neural recordings. Circulation. 1989;80:65–77.PubMedGoogle Scholar
  80. Flapan AD, Nolan J, Neilson JM, Ewing DJ. Effect of captobril on cardiac parasympathetic activity in chronic cardiac failure secondary to coronary artery disease. Am J Cardiol. 1992;15:532–5.Google Scholar
  81. Fleischer J, Nielsen R, Laugesen E, Nygaard H, Poulsen PL, Ejskjaer N. Self-monitoring of cardiac autonomic function at home is feasible. J Diabetes Sci Technol. 2011;5:107–12.PubMedGoogle Scholar
  82. Fleischer J, Charles M, Tarnow L, Jensen KS, Nygaard H, Sandbaek A, Ejskjaer N. Paper electrocardiograph strips may contain overlooked clinical information in screen-detected type 2 diabetes patients. J Diabetes Sci Technol. 2012;6:74–80.PubMedGoogle Scholar
  83. Frenneaux MP. Autonomic changes in patients with heart failure and in post-myocardial infarction patients. Heart. 2004;90:1248–55.PubMedGoogle Scholar
  84. Friedman HS. Heart rate variability in atrial fibrillation related to left atrial size. Am J Cardiol. 2004;15:705–9.Google Scholar
  85. Furedy JJ, Szabo A, Péronnet F. Effects of psychological and physiological challenges on heart rate, T-wave amplitude, and pulse-transit time. Int J Psychophysiol. 1996;22:173–83.PubMedGoogle Scholar
  86. Gajek J, Zysko D, Chlebda E. Heart rate variability in workers chronically exposed to lead. Kardiol Pol. 2004;61:21–30.PubMedGoogle Scholar
  87. Galletly DC, Tobin PD, Robinson BJ, Corfiatis T. Effect of inhalation of 30% nitrous oxide on spectral components of heart rate variability in conscious man. Clin Sci (Lond). 1993;85:389–92.Google Scholar
  88. Galletly DC, Westenberg AM, Robinson BJ, Corfiatis T. Effects of halothane, isoflurane and fentanyl on spectral components of heart rate variability. Br J Anaesth. 1994a;72:177–80.PubMedGoogle Scholar
  89. Galletly DC, Buckley DH, Robinson BJ, Corfiatis T. Heart rate variability during propofol anaesthesia. Br J Anaesth. 1994b;72:219–20.PubMedGoogle Scholar
  90. Garde S, Regalado MG, Schechtman VL, Khoo MC. Nonlinear dynamics of heart rate variability in cocaine-exposed neonate during sleep. Am J Physiol Heart Circ Physiol. 2001;280:H2920–8.PubMedGoogle Scholar
  91. Garfinkel A, Chen PS, Walter DO, Karagueuzian HS, Kogan B, Evans SJ, Karpoukhin M, Hwang C, Uchida T, Gotoh M, et al. Quasiperiodicity and chaos in cardiac fibrillation. J Clin Invest. 1997;99:305–14.PubMedGoogle Scholar
  92. Gentlesk PJ, Wiley T, Taylor AJ. A prospective evaluation of the effect of simvastatin on heart rate variability in non-ischemic cardiomyopathy. Am Heart J. 2005;150:478–83.PubMedGoogle Scholar
  93. Gerritsen J, Dekker JM, TenVoorde BJ, Kostense PJ, Heine RJ, Bouter LM, Heethaar RM, Stehouwer CD. Impaired autonomic function is associated with increased mortality, especially in subjects with diabetes, hypertension, or a history of cardiovascular disease: the Hoorn Study. Diabetes Care. 2001;24:1793–8.PubMedGoogle Scholar
  94. Ghuran A, Reid F, La Rovere MT, Schmidt G, Bigger Jr JT, Camm AJ, Schwartz PJ, Malik M, ATRAMI Investigators. Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The Autonomic Tone and Reflexes After Myocardial Infarction substudy). Am J Cardiol. 2002;89:184–90.PubMedGoogle Scholar
  95. Giuliani A, Piccirillo G, Marigliano V, Colosimo A. A nonlinear explanation of aging-induced changes in heartbeat dynamics. Am J Physiol. 1998;275:H1455–61.PubMedGoogle Scholar
  96. Glassman AH, Bigger JT, Gaffney M, Van Zyl LT. Heart rate variability in acute coronary syndrome patients with major depression: influence of sertraline and mood improvement. Arch Gen Psychiatry. 2007;64:1025–31.PubMedGoogle Scholar
  97. Gol M, Baris N, Guneri S, Posaci C. The effect of raloxifene on cardiac autonomic regulation in osteoporotic women. Am J Obstet Gynecol. 2006;194:1249–54.PubMedGoogle Scholar
  98. Goldberger AL, Luis AN, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE. Physiobank, Physiotoolkit, and Physionet – components of a new research source for complex physiologic signals. Circulation. 2000;101:e215–20.PubMedGoogle Scholar
  99. Goldstein B, McNames J, McDonald BA, Ellenby M, Lai S, Sun ZY, Krieger D, Sclabassi RJ. Physiologic data acquisition system and database for the study of disease dynamics in the intensive care unit. Crit Care Med. 2003;31:433–41.PubMedGoogle Scholar
  100. Gonzalez JJ, Cordero JJ, Feria M, Pereda E. Detection and sources of nonlinearity in the variability of cardiac R-R intervals and blood pressure in rats. Am J Physiol Heart Circ Physiol. 2000;279:H3040–6.PubMedGoogle Scholar
  101. Grimm W, Christ M, Müller HH, Maisch B. Noninvasive arrhythmia risk stratification in idiopathic dilated cardiomyopathy: results of the Marburg Cardiomyopathy study. Circulation. 2003a;108:2883–91.PubMedGoogle Scholar
  102. Grimm W, Schmidt G, Maisch B, Sharkova J, Müller HH, Christ M. Prognostic significance of heart rate turbulence following ventricular premature beats in patients with idiopathic dilated cardiomyopathy. J Cardiovasc Electrophysiol. 2003b;14:819–24.PubMedGoogle Scholar
  103. Grimm W, Sharkova J, Christ M, Schneider R, Schmidt G, Maisch B. Heart rate turbulence following ventricular premature beats in healthy controls. Ann Noninvasive Electrocardiol. 2003c;8:127–31.PubMedGoogle Scholar
  104. Grogan EL, Morris JA, Norris PR, France DJ, Ozdas A, Stiles RA, Harris PA, Dawant BM, Speroff T. Reduced heart rate volatility: an early predictor of death in trauma patients. Ann Surg. 2004;240:547–54.PubMedGoogle Scholar
  105. Guo YF, Stein PK. Circadian rhythm in the cardiovascular system: considerations in non-invasive electrophysiology. Card Electrophysiol Rev. 2002;6:267–72.PubMedGoogle Scholar
  106. Hadase M, Azuma A, Zen K, Asada S, Kawasaki T, Kamitani T, Kawasaki S, Sugihara H, Matsubara H. Very low frequency power of heart rate variability is a powerful predictor of clinical prognosis in patients with congestive heart failure. Circ J. 2004;68:343–7.PubMedGoogle Scholar
  107. Haegele-Link S, Claus D, Dücker S, Vogt T, Birklein F. Evaluation of the autonomic nervous system using the FAN® device – range of normal and examples of abnormal. Open Neurol J. 2008;2:12–9.PubMedGoogle Scholar
  108. Haensel A, Mills PJ, Nelesen RA, et al. The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology. 2008;33:1305–12.PubMedGoogle Scholar
  109. Hautala AJ, Mäkikallio TH, Kiviniemi A, Laukkanen RT, Nissilä S, Huikuri HV, Tulppo MP. Cardiovascular autonomic function correlates with the response to aerobic training in healthy sedentary subjects. Am J Physiol Heart Circ Physiol. 2003a;285:H1747–52.PubMedGoogle Scholar
  110. Hautala AJ, Mäkikallio TH, Seppänen T, Huikuri HV, Tulppo MP. Short-term correlation properties of R-R interval dynamics at different exercise intensity levels. Clin Physiol Funct Imaging. 2003b;23:215–23.PubMedGoogle Scholar
  111. Hayano J, Yamada M, Sakakibara Y, Fujinami T, Yokoyama K, Watanabe Y, Takata K. Short- and long-term effects of cigarette smoking on heart rate variability. Am J Cardiol. 1990;65:84–8.PubMedGoogle Scholar
  112. Hayano J, Yasumo F, Okada A, Mukai S, Fujinami T. Respiratory sinus arrhythmia. A phenomenon improving pulmonary gas exchange and circulatory efficiency. Circulation. 1996;94:842–7.PubMedGoogle Scholar
  113. Hayano J, Kiyono K, Struzik ZR, Yamamoto Y, Watanabe E, Stein PK, Watkins LL, Blumenthal JA, Carney RM. Increased non-Gaussianity of heart rate variability predicts cardiac mortality after an acute myocardial infarction. Front Physiol. 2011;2:65.PubMedGoogle Scholar
  114. Heffernan KS, Fahs CA, Shinsako KK, Jae SY, Fernhall B. Heart rate recovery and heart rate complexity following resistance exercise training an detraining in young men. Am J Physiol Heart Circ Physiol. 2007;293:H3180–6.PubMedGoogle Scholar
  115. Hegbom F, Sire S, Heldal M, Orning OM, Stavem K, Gjesdal K. Short-term exercise training in patients with chronic atrial fibrillation: effects on exercise capacity, AV conduction, and quality of life. J Cardiopulm Rehabil. 2006;26:24–9.PubMedGoogle Scholar
  116. Heinz A, Kluge U, editors. Einwanderung – Bedrohung oder Zukunft?: Mythen und Fakten zur Integration. Frankfurt a.M: Campus Verlag; 2012.Google Scholar
  117. Hennen R, Friedrich I, Hoyer D, Nuding S, Rauchhaus M, Schulze M, Schlisske S, Schwesig R, Schlitt A, Buerke M, Mueller-Werdan U, Werdan K, Schmidt H. Autonome Dysfunktion und Betablocker beim Multiorgandysfunktionssyndrom. Dtsch Med Wochenschr. 2008;133:2500–4.PubMedGoogle Scholar
  118. Howell SJ, Wanigasekera V, Young JD, Gavaghan D, Sear JW, Garrard CS. Effects of propofol and thiopentone, and benzodiazepine premedication on heart rate variability measured by spectral analysis. Br J Anaesth. 1995;74:168–73.PubMedGoogle Scholar
  119. Huang HH, Chan HL, Lin PL, Wu CP, Huang CH. Time frequency spectral analysis of heart rate variability during induction of general anaesthesia. Br J Anaesth. 1997;79:754–8.PubMedGoogle Scholar
  120. Huang JL, Wen ZC, Lee WL, Chang MS, Chen SA. Changes of autonomic tone before the onset of paroxysmal atrial fibrillation. Int J Cardiol. 1998;66:275–83.PubMedGoogle Scholar
  121. Hugdahl K. Psychophysiology. The mind-body-perspective. London: Harvard University Press; 2001.Google Scholar
  122. Hughes JW, Stoney CM. Depressed mood is related to high-frequency heart rate variability during stressors. Psychosom Med. 2000;62:796–803.PubMedGoogle Scholar
  123. Huikuri HV, Pikkujamsa SM, Airaksinen KE, Ikaheimo MJ, Rantala AO, Kauma H, Lilja M, Kesaniemi YA. Sex related differences in autonomic modulation of heart rate in middle-aged subjects. Circulation. 1996a;94:122–5.PubMedGoogle Scholar
  124. Huikuri HV, Ylitalo A, Pikkujämsä SM, Ikäheimo MJ, Airaksinen KE, Rantala AO, Lilja M, Kesäniemi YA. Heart rate variability in systemic hypertension. Am J Cardiol. 1996b;77:1073–7.PubMedGoogle Scholar
  125. Huikuri HV, Mäkikallio TH, Airaksinen J, Seppänen T, Puuka P, Räihä IJ, Sourander LB. Power-Law relationship of heart rate variability as a predictor of mortality in the elderly. Circulation. 1998;97:2031–6.PubMedGoogle Scholar
  126. Huikuri HV, Makikallio TH, Perkiomaki J. Measurement of heart rate variability by methods based on nonlinear dynamics. J Electrocardiol. 2003a;36(Suppl):95–9.PubMedGoogle Scholar
  127. Huikuri HV, Mäkikallio TH, Raatikainen MJ, Perkiömäki J, Castellanos A, Myerburg RJ. Prediction of sudden cardiac death. Circulation. 2003b;108:110–5.PubMedGoogle Scholar
  128. Husser O, Husser D, Stridh M, Sörnmo L, Corino VD, Mainardi LT, Lombardi F, Klein HU, Olsson SB, Bollmann A. Exercise testing for non-invasive assessment of atrial electrophysiological properties in patients with persistent atrial fibrillation. Europace. 2007;9:627–32.PubMedGoogle Scholar
  129. Işler Y, Kuntalp M. Combining classical HRV indices with wavelet entropy measures improves to performance in diagnosing congestive heart failure. Comput Biol Med. 2007;37:1502–10.PubMedGoogle Scholar
  130. Jakobsen J, Hauksson P, Vestergaard P. Heart rate variation in patients treated with antidepressants: an index of anticholinergic effects? Psychopharmacology (Berl). 1984;84:544–8.Google Scholar
  131. Jeron A, Kaiser T, Hengstenberg C, Löwel H, Riegger GA, Holmer S. Association of the heart rate turbulence with classic risk stratification parameters in postmyocardial infarction patients. Ann Noninvasive Electrocardiol. 2003;8:296–301.PubMedGoogle Scholar
  132. Kalda J, Säkki M. Non-linear and scale-invariant analysis of the heart rate variability. ArXiv: physics/ 0303041 v1. 2003.Google Scholar
  133. Kalda J, Säkki M, Vainu M, Laan M. Zipf’s law in human heartbeat dynamics. ArXiv: physics/ 01110075 v1.2001.Google Scholar
  134. Kamata J, Nakai K, Chiba N, Hosokawa S, Sato Y, Nasu M, Sasaki T, Kitahara H, Izumoto H, Yagi Y, Itoh C, Hiramori K, Kawazoe K. Electrocardiographic nature of restored sinus rhythm after Cox maze procedure in patients with chronic atrial fibrillation who also had other cardiac surgery. Heart. 1997;77:50–5.Google Scholar
  135. Kamphuis MH, Geerlings MI, Dekker JM, Giampaoli S, Nissinen A, Grobbee DE, Kromhout D. Autonomic dysfunction: a link between depression and cardiovascular mortality? The FINE Study. Eur J Cardiovasc Prev Rehabil. 2007;14:796–802.PubMedGoogle Scholar
  136. Kanaya N, Hirata N, Kurosawa S, Nakayama M, Namiki A. Differential effects of propofol and sevoflurane on heart rate variability. Anesthesiology. 2003;98:34–40.PubMedGoogle Scholar
  137. Kaplan DT, Furman MI, Pincus SM, Ryan SM, Lipsitz LA, Goldberger AL. Aging and the complexity of cardiovascular dynamics. Biophys J. 1991;59:945–9.PubMedGoogle Scholar
  138. Karapetian GK, Engels HJ, Gretebeck KA, Gretebeck RJ. Effect of caffeine on LT, VT and HRVT. Int J Sports Med. 2012;33:507–13.PubMedGoogle Scholar
  139. Karmakar C, Jelinek H, Khandoker A, Tulppo M, Makikallio T, Kiviniemi A, Huikuri H, Palaniswami M. Identifying increased risk of post-infarct people with diabetes using multi-lag tone-entropy analysis. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:25–8; (quoted by abstract).PubMedGoogle Scholar
  140. Kesek M, Franklin KA, Sahlin C, Lindberg E. Heart rate variability and sleep apnoea in a population based study of 387 women. Clin Physiol Funct Imaging. 2009;29:309–15.PubMedGoogle Scholar
  141. Khaikin Y, Dorian P, Baker B, Shapiro C, Sandor P, Mironov D, Irvine J, Newman D. Autonomic correlates of antidepressant treatment using heart rate variability analysis. Can J Psychiatry. 1998;43:183–6.Google Scholar
  142. Khand AU, Rankin AC, Cleland JG, Gemmell I, Clark E, Macfarlane PW. The assessment of autonomic function in chronic atrial fibrillation: description of a non-invasive technique based on circadian rhythm of atrioventricular nodal functional refractory periods. Europace. 2006;8:927–34.PubMedGoogle Scholar
  143. Kikillus N, Hammer G, Bolz A. Identifizieren von Patienten mit Vorhofflimmern anhand von HRV-Parametern. Biomed Tech (Berl). 2008;53:8–15.Google Scholar
  144. Kimura T, Matsumoto T, Akiyoshi M, Owa Y, Miyasaka N, Aso T, Moritani T. Body fat and blood lipids in postmenopausal women are related to resting autonomic nervous system activity. Eur J Appl Physiol. 2006;97:542–7.PubMedGoogle Scholar
  145. Kiviniemi AM, Tulppo MP, Wichterle D, Hautala AJ, Tiinanen S, Seppänen T, Mäkikallio TH, Huikuri HV. Novel spectral indexes of heart rate variability as predictors of sudden and non-sudden cardiac death after an acute myocardial infarction. Ann Med. 2007a;39:54–62.PubMedGoogle Scholar
  146. Kiviniemi AM, Hautala AJ, Kinnunen H, Tulppo MP. Endurance training guided individually by daily heart rate variability measurements. Eur J Appl Physiol. 2007b;101:743–51.PubMedGoogle Scholar
  147. Kon H, Nagano M, Tanaka F, et al. Association of decreased variation of R-R interval and elevated serum c-reactive protein level in a general population in Japan. Int Heart J. 2006;47:867–76.PubMedGoogle Scholar
  148. Kop WJ, Stein PK, Tracy RP, Barzilay JI, Schulz R, Gottdiener JS. Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosom Med. 2010;72:626–35.PubMedGoogle Scholar
  149. Koskinen T, Kähönen M, Jula A, Laitinen T, Keltikangas-Järvinen L, Viikari J, Välimaki I, Raitakari OT. Short-term heart rate variability in healthy young adults. The cardiovascular Risk in Young Finns Study. Auton Neurosci. 2009a;145:81–8.PubMedGoogle Scholar
  150. Koskinen T, Kähönen M, Jula A, Mattson N, Laitinen T, Keltikangas-Järvinen L, Viikari J, Välimäki I, Rönnemaa T, Raitakari OT. Metabolic syndrome and short heart rate variability in young adults. The cardiovascular risk in young Finns study. Diabet Med. 2009b;26:354–61.PubMedGoogle Scholar
  151. Koyama J, Watanabe J, Yamada A, Koseki Y, Konno Y, Toda S, Shinozaki T, Miura M, Fukuchi M, Ninomiya M, Kagaya Y, Shirato K. Evaluation of heart-rate turbulence as a new prognostic marker in patients with chronic heart failure. Circ J. 2002;66:902–7.PubMedGoogle Scholar
  152. Kreindler DM, Lumsden CJ. The effects of irregular sampling and missing data on largest lyapunov exponents. Nonlinear Dynamics Psychol Life Sci. 2007;11:401–12.PubMedGoogle Scholar
  153. Krstacic G, Martinis M, Vargovic E, Knezevic A, Krstacic A: Non-linear dynamics in patients with stable angina pectoris. ArXiv: physics/0110010 v1.2001.Google Scholar
  154. Krum H, Bigger JT, Goldsmith RL, Packer M. Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure. J Am Coll Cardiol. 1995;25:289–94.PubMedGoogle Scholar
  155. Kupper NH, Willemsen G, van den Berg M, de Boer D, Posthuma D, Boomsma DI, de Geus EJ. Heritability of ambulatory heart rate variability. Circulation. 2004;110:2792–6.PubMedGoogle Scholar
  156. Kuusela TA, Jartti TT, Tahvanainen KU, Kaila TJ. Nonlinear methods of biosignal analysis in assessing terbutaline-induced heart rate and blood pressure changes. Am J Physiol Heart Circ Physiol. 2002;282:H773–83.PubMedGoogle Scholar
  157. Laitio T, Jalonen J, Kuusela T, Scheinin H. The role of heart rate variability in risk stratification for adverse postoperative cardiac events. Anesth Analg. 2007;105:1548–60.PubMedGoogle Scholar
  158. Lampert R, Ickovics JR, Viscoli CJ, Horwitz RJ, Lee FA. Effects of propanolol on recovery of heart rate variabilità following acute myocardial infarction and relation to outcome in the Beta Blocker Heart Attack Trial. Am J Cardiol. 2003;91:137–42.PubMedGoogle Scholar
  159. Lanza GA, Sgueglia GA, Cianflone D, Rebuzzi AG, Angeloni G, Sestito A, Infusiono F, Crea F, Maseri A, SPAI (Stratificazione Prognostica dell’Angina Instabile) Investigators. Relation of heart rate variability to serum levels of C-reactive protein in patients with unstable angina pectoris. Am J Cardiol. 2006;97:1702–6.PubMedGoogle Scholar
  160. LaViolette RA, Tolle CR, McJunkin TR, Stoner DL. Combining the ApEn statistic with surrogate data analysis for the detection of nonlinear dynamics in time series. 2004 (unpublished report).Google Scholar
  161. Lempel A, Ziv J. On the complexity of finite sequences. IEEE Trans Inf Theory. 1976;22:75–81.Google Scholar
  162. Leong KS, Mann P, Wallymahmed M, MacFarlane IA, Wilding JP. Abnormal heart rate variability in adults with growth hormone deficiency. J Clin Endocrinol Metab. 2000;85:628–33.PubMedGoogle Scholar
  163. Lerma C, Infante O, Perez-Grovas H, Jose MV. Pincare plot indices of heart rate variability capture dynamic adaptations after haemodialysis in chronic real failure patients. Clin Physiol Funct Imaging. 2003;23:72–80.PubMedGoogle Scholar
  164. Levy WC, Cerqueira MD, Harp GD, Johannessen KA, Abrass IB, Schwartz RS, Stratton JR. Effect of endurance exercise training on heart rate variability in healthy young and older man. Am J Cardiol. 1998;82:1236–41.PubMedGoogle Scholar
  165. Licht CM, de Geus EJ, Zitman FG, Hoogendijk WJ, Van Dyck R, Penninx BW. Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Arch Gen Psychiatry. 2008;65:1358–67.PubMedGoogle Scholar
  166. Liebovitch LS, Todorov AT, Zochowski M, Scheurle D, Colgin L, Wood MA, Ellenbogen KA, Herre JM, Bernstein RC. Nonlinear properties of cardiac rhythm abnormalities. Phys Rev E. 1999;59:3312–9.Google Scholar
  167. Lin JL, Chan HL, Du CC, LIN IN, Lai CW, Lin KT, Wu CP, Tseng YZ, Lien WP. Long-term beta-blocker therapy improves autonomic nervous regulation in advanced congestive heart failure: a longitudinal heart rate variability study. Am Heart J. 1999;137:658–65.PubMedGoogle Scholar
  168. Lin LY, Lai LP, Lin JL, Du CC, Shau WY, Chan HL, Tseng YZ, Huang SK. Tight mechanism correlation between heart rate turbulence and baroreflex sensitivity: sequential autonomic blockade analysis. J Cardiovasc Electrophysiol. 2002;13:427–31.PubMedGoogle Scholar
  169. Lindgren KS, Mäkikallio TH, Seppänen T, Raatikainen MJ, Castellanos A, Myerburg RJ, Huikuri HV. Heart rate turbulence after ventricular and atrial premature beats in subjects without structural heart disease. J Cardiovasc Electrophysiol. 2003;14:447–52.PubMedGoogle Scholar
  170. Lu CC, Ho ST, Tung CS. Anesthetic management in autonomic disorders. In: Robertson DW et al, editors. Primer on the Autonomic Nervous System. Academic Press, London; 2012. p. 665–8.Google Scholar
  171. Lucini D, Norbiato G, Clerici M, Pagani M. Hemodynamic and autonomic adjustments to real life stress conditions in humans. Hypertension. 2002;39:184–8.PubMedGoogle Scholar
  172. MacFadyen RJ, Barr CS, Struthers AD. Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients. Cardiovasc Res. 1997;35:30–4.PubMedGoogle Scholar
  173. Madden K, Savard GK. Effects of mental state on heart rate and blood pressure variability in men and women. Clin Physiol. 1995;15:557–69.PubMedGoogle Scholar
  174. Madsen T, Christensen JH, Toft E, et al. C-reactive protein is associated with heart rate variability. Ann Noninvasive Electrocardiol. 2007;12:216–22.PubMedGoogle Scholar
  175. Maestri R, Pinna GD, Accardo A, Allegrini P, Balocchi R, D'Addio G, Ferrario M, Menicucci D, Porta A, Sassi R, Signorini MG, La Rovere MT, Cerutti S. Nonlinear indices of heart rate variability in chronic heart failure patients: redundancy and comparative clinical value. J Cardiovasc Electrophysiol. 2007;18:425–33.PubMedGoogle Scholar
  176. Mainardi LT, Bianchi A, Cerutti S. Time-frequency and time-varying analysis for assessing the dynamic responses of cardiovascular control. Crit Rev Biomed Engl. 2002;30:175–217.Google Scholar
  177. Malik M, Camm AJ, Janse MJ, Julian DG, Frangin GA, Schwartz PJ. Depressed heart rate variability identifies postinfarction patients who might benefit from prophylactic treatment with amiodarone: a substudy of EMIAT (The European Myocardial Infarct Amiodarone Trial). J Am Coll Cardiol. 2000;35:1263–75.PubMedGoogle Scholar
  178. Malpas SC. Neural influences on cardiovascular variability: possibilities and pitfalls. Am J Physiol Heart Circ Physiol. 2002;282:H6–20.PubMedGoogle Scholar
  179. Manzella D, Grella R, Esposito K, Giugliano D, Barbagallo M, Paolisso G. Blood pressure and cardiac autonomic nervous system in obese type 2 diabetic patients: effect of metformin administration. Am J Hypertens. 2004;17:223–7.PubMedGoogle Scholar
  180. Marwan N, Wessel N, Meyerfeldt U, Schirdewan A, Kurths J. Recurrence plot based measures of complexity and its application to heart rate variability data. ArXiv: physics/ 0201064 v2. 2002.Google Scholar
  181. Matsumoto M, Yamashita T, Fukuda E, Sagara K, Iinuma H, Fu LT. Relation between variability of ventricular response intervals and exercise capacity in patients with non-valvular atrial fibrillation. Circ J. 2004;68:294–6.PubMedGoogle Scholar
  182. Mazzeo AT, La Monaca E, Di Leo R, Vita G, Santamaria LB. Heart rate variability: a diagnostic and prognostic tool in anesthesia and intensive care. Acta Anaesthesiol Scand. 2011;55:797–811.PubMedGoogle Scholar
  183. Michaloudis D, Kochiadakis G, Georgopoulou G, Fraidakis O, Chlouverakis G, Petrou A, Pollard BJ. The influence of premedication on heart rate variability. Anaesthesia. 1998;53:446–53.PubMedGoogle Scholar
  184. Migliaro ER, Canetti R, Contreras P, Hakas M, Eirea G, Machado A. Short-term studies of heart rate variability: comparison of two methods for recording. Physiol Meas. 2004;25:N15–20.PubMedGoogle Scholar
  185. Millis RM, Austin RE, Bond V, Faruque M, Goring KL, Hickey BM, Blakely R, Demeersman RE. Effects of high-carbohydrate and high-fat dietary treatments on measures of heart rate variability and sympathovagal balance. Life Sci. 2009;85:141–5.PubMedGoogle Scholar
  186. Mitro P, Mudráková K, Micková H, Dudás J, Kirsch P, Valocik G. Hemodynamic parameters and heart rate variability during a tilt test in relation to gene polymorphism of rennin-angiotensin and serotonin system. Pacing Clin Electrophysiol. 2008;31:1571–80.PubMedGoogle Scholar
  187. Molfino A, Fiorentini A, Tubani L, Martuscelli M, Fanelli FR, Laviano A. Body mass index is related to autonomic nervous system activity as measured by heart rate variability. Eur J Clin Nutr. 2009;63:1263–5.PubMedGoogle Scholar
  188. Morris JA, Norris PR, Moore JH, Jenkins JM, Williams AE, Canter JA. Genetic variation in the autonomic nervous system affects mortality – a study of 1095 trauma patients. J Am Coll Surg. 2009;208:663–8.PubMedGoogle Scholar
  189. Mortara A, Sleight P, Pinna G, et al. Abnormal awake respiratory patterns are common in chronic heart failure and may prevent evaluation of autonomic tone by measures of heart rate variability. Circulation. 1997;96:246–52.PubMedGoogle Scholar
  190. Moser M, Lehofer M, Sedminek A, Lux M, Zapotoczky HG, Kenner T, Noordergraaf A. Heart rate variability as a prognostic tool in cardiology. Circulation. 1994;90:1078–82.PubMedGoogle Scholar
  191. Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB. Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation. 2005;112:1945–52.PubMedGoogle Scholar
  192. Mozaffarian D, Stein PK, Prineas RJ, Siscovick DS. Dietary fish and omega-3 fatty acid consumption and heart rate variability in US adults. Circulation. 2008;117:1130–7.PubMedGoogle Scholar
  193. Muenter NK, Watenpaugh DE, Wasmund WL, Wasmund SL, Maxwell SA, Smith ML. Effect of sleep restriction on orthostatic cardiovascular control in humans. J Appl Physiol. 2000;88:966–72.PubMedGoogle Scholar
  194. Mujica-Parodi LR, Yeragani V, Malaspina D. Nonlinear complexity and spectral analyses of heart rate variability in medicated and unmedicated patients with schizophrenia. Neuropsychobiology. 2005;51:10–5.PubMedGoogle Scholar
  195. Mulders HPG, Meijman TF, O’Hanlon JF, Mulder G. Differential psychophysiological reactivity of city bus drivers. Ergonomics. 1982;25:1003–11.PubMedGoogle Scholar
  196. Munjal S, Koval T, Muhammad R, Demmel V, Roethig HJ, Mendes P, Unverdorben M. Heart rate variability increases with reductions in cigarette smoke exposure after 3 days. J Cardiovasc Pharmacol Ther. 2009;14:192–8.PubMedGoogle Scholar
  197. Nagakawa M, Onie T, Takahashi N, Taniguchi Y, Anan F, Yonemochi H, Saikawa T. Influence of menstrual cycle on QT interval dynamics. Pacing Clin Electrophysiol. 2006;29:607–13.Google Scholar
  198. Nakamura Y, Yamamoto Y, Muraoka I. Autonomic regulation of heart rate during physical exercise and fractal dimension of heart rate variability. J Appl Physiol. 1993;74:875–81.PubMedGoogle Scholar
  199. Nakatsuka I, Ochiai R, Takeda J. Changes in heart rate variability in sevoflurane and nitrous oxide anesthesia: effects of respiration and depth of anesthesia. J Clin Anesth. 2002;14:196–200.PubMedGoogle Scholar
  200. Neumann SA, Tingley WG, Conklin BR, Schrader CJ, Peet E, Muldoon MF, Jennings JR, Ferrell RE, Manuck SB. AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans. Psychophysiology. 2009;46:466–72.PubMedGoogle Scholar
  201. Niskanen JP, Tarvainen MP, Ranta-Aho PO, Karjalainen PA. Software for advanced HRV analysis. Comput Methods Programs Biomed. 2004;76:73–81.PubMedGoogle Scholar
  202. Nolan RP, Reid GJ, Seidelin PH, et al. C-reactive protein modulates vagal heart rate control in patients with coronary artery disease. Clin Sci. 2007;112:449–56.PubMedGoogle Scholar
  203. Notarius CF, Floras JS. Limitations of the use of spectral analysis of heart rate variability for the estimation of cardiac sympathetic activity in heart failure. Europace. 2001;3:29–38.PubMedGoogle Scholar
  204. Notarius CF, Butler GC, Ando S, Pollard MJ, Senn B, Floras JS. Dissociation between microneurographic and heart rate variability estimates of sympathetic tone in normal subjects and patients with heart failure. Clin Sci. 1999;96:557–65.PubMedGoogle Scholar
  205. Nunan D, Donovan G, Jakovljevic DG, Hodges LD, Sandercock GR, Brodie DA. Validity and reliability of short-term heart rate variability from the Polar 810D. Med Sci Sports Exerc. 2009;41:243–50.PubMedGoogle Scholar
  206. Nunan D, Sandercock GR, Brodie DA. A quantitative systematic review of normal values for short-term heart rate variability in healthy adults. Pacing Clin Electrophysiol. 2010;33:1407–17.PubMedGoogle Scholar
  207. Nussinovitch U, Cohen O, Kaminer K, Ilani J, Nussinovitch N. Evaluating reliability of ultra-short ECG indices of heart rate variability in diabetes mellitus patients. J Diabetes Complications. 2012;26:450–3.PubMedGoogle Scholar
  208. O’Keefe JH, Abuissa H, Sastre A, Steinhaus DM, Harris WS. Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. Am J Cardiol. 2006;97:1127–30.PubMedGoogle Scholar
  209. Okamoto-Mizuno K, Tsuzuki K, Mizuno K, Ohshiro Y. Effects of low ambient temperature on heart rate variability during sleep in humans. Eur J Appl Physiol. 2009;105:191–7.PubMedGoogle Scholar
  210. Okushima K, Kohjitani A, Asano Y, Sugiyama K. Inhalational conscious sedation with nitrous oxide enhances the cardiac parasympathetic component of heart rate variability. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:e1–5.PubMedGoogle Scholar
  211. Orlov S, Bril V, Orszag A, Perkins BA. Heart rate variability and sensorimotor polyneuropathy in type 1 diabetes. Diabetes Care. 2012;35:809–16.PubMedGoogle Scholar
  212. Owen N, Streptoe A. Natural killer cell and proinflammatory cytokine responses to mental stress: associations with heart rate and heart rate variability. Biol Psychol. 2003;63:101–15.PubMedGoogle Scholar
  213. Ozdemir M, Arslan U, Türkoğlu S, Balcioğlu S, Cengel A. Losartan improves heart rate variability and heart rate turbulence in heart failure due to ischemic cardiomyopathy. J Card Fail. 2007;13:812–7.PubMedGoogle Scholar
  214. Papaioannou TG, Vlachopoulos C, Ioakeimidis N, Stefanidis C. Nonlinear dynamics of blood pressure variability after caffeine consumption. Clin Med Res. 2006;4:114–8.PubMedGoogle Scholar
  215. Pardo Y, Merz CN, Velasquez I, Paul-Labrador M, Agarwala A, Peter CT. Exercise conditioning and heart rate variability: evidence of a threshold effect. Clin Cardiol. 2000;23:615–20.PubMedGoogle Scholar
  216. Pavithran P, Madanmohan T, Nandeesha H. Sex differences in short-term heart rate variability in patients with newly diagnosed essential hypertension. J Clin Hypertens (Greenwich). 2008;10:904–10.Google Scholar
  217. Peng CK, Buldyrev SV, Havlin S, Simons M, Stanley HE, Goldberger AL. Mosaic organization of DNA nucleotides. Phys Rev E. 1994;49:1685–9.Google Scholar
  218. Peng CK, Havlin S, Stanley HE, Goldberger AL. Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. Chaos. 1995;5:82–7.PubMedGoogle Scholar
  219. Perkiömäki JS, Makikallio TH, Huikuri HV. Fractal and complexity measures of heart rate variability. Clin Exp Hypertens. 2005;27:149–58.PubMedGoogle Scholar
  220. Petretta M, Spinelli L, Apicella C, Vicario ML, Testa G, Volpe M, Bonaduce D. Effects of losartan treatment on cardiac autonomic control during volume loading in patients with DCM. Am J Physiol Heart Circ Physiol. 2000;279:H86–92.PubMedGoogle Scholar
  221. Pincus SM. Greater signal regularity may indicate increased system isolation. Math Biosci. 1994;122:161–81.PubMedGoogle Scholar
  222. Piot O, Chauvel C, Lazarus A, Pellerin D, David D, Leneveut-Ledoux L, Guize L, Le Heuzey JY. Effects of a selective A1-adenosine receptor agonist on heart rate and heart rate variability during permanent atrial fibrillation. Pacing Clin Electrophysiol. 1998;21:2459–64.PubMedGoogle Scholar
  223. Poirier P, Hernandez TL, Weil KM, Shepard TJ, Eckel RH. Impact of diet-induced weight loss on the cardiac autonomic nervous system in severe obesity. Obes Res. 2003;11:1040–7.PubMedGoogle Scholar
  224. Pop-Busui R, Low PA, Waberski BH, Martin CL, Albers JW, Feldman EL, Sommer C, Cleary PA, Lachin JM. Herman WH; DCCT/EDIC Research Group: effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC). Circulation. 2009;119:2886–93.PubMedGoogle Scholar
  225. Porges SW. Autonomic regulation and attention. In: Cmpbell BA, Hayne H, Richardson R, editors. Attention and informational processing in infants and adults. Hillsdale: Erlbaum; 1992. p. 201–23.Google Scholar
  226. Posener JA, DeBattista C, Veldhuis JD, Province MA, Williams GH, Schatzberg AF. Process irregularity of cortisol and adrenocortocotropin secretion in men with major depressive disorder. Psychoneuroendocrinology. 2004;29:1129–37.PubMedGoogle Scholar
  227. Pousset F, Copie X, Lechat P, Jaillon P, Boissel JP, Hetzel M, Fillette F, Remme W, Guize L, Le Heuzy JY. Effects of bisoprolol on heart rate variability in heart failure. Am J Cardiol. 1996;15:612–7.Google Scholar
  228. Power KL, Balmes J, Solomon C. Controlled exposure to combined particles and ozone decreases heart rate variability. J Occup Environ Med. 2008;50:1253–60.PubMedGoogle Scholar
  229. Probst-Hensch NM, Imboden M, Felbert Dietrich D, Barthélemy JC, Ackermann-Liebrich U, Berger W, Gaspoz JM, Schwartz J. Gluthatione S-transferase polymorphisms, passive smoking, obesity, and heart rate variability in nonsmokers. Environ Health Perspect. 2008;116:1494–9.PubMedGoogle Scholar
  230. Psychari SN, Apostolou TS, Iliodromitis EK, et al. Inverse relation of C-reactive protein levels to heart rate variability in patients after acute myocardial infarction. Hellenic J Cardiol. 2007;48:64–71.PubMedGoogle Scholar
  231. Raab C, Wessel N, Schirdewan A, Kurths J. Large-scale dimension densities of heart rate variability analysis. Phys Rev E Stat Nonlin Soft Matter Phys. 2006;73:041907.PubMedGoogle Scholar
  232. Rapp PE, Watanabe TA, Faure P, Cellucci CJ. Nonlinear signal classification. Int J Bifurc Chaos. 2002;12:1273–93.Google Scholar
  233. Rauh R, Burkert M, Siepmann M, Mueck-Weymann M. Acute effects of caffeine on heart rate variability in habitual caffeine consumers. Clin Physiol Funct Imaging. 2006;26:163–6.PubMedGoogle Scholar
  234. Ravaja N, Raikkonen K, Lyytinen H, Lehtimaki T, Keltikangas-Jarvinen L. Apolipoprotein E phenotypes and cardiovascular responses to experimentally induced mental stress in adolescent boys. J Behav Med. 1997;20:571–87.PubMedGoogle Scholar
  235. Rawles JM, Rowland E. Is the pulse in atrial fibrillation irregularly regular? Br Heart J. 1986;56:4–11.PubMedGoogle Scholar
  236. Rechlin T. The effect of amitriptyline, doxepin, fluvoxamine, and paroxetine treatment on heart rate variability. J Clin Psychopharmacol. 1994;14:392–5.PubMedGoogle Scholar
  237. Rechlin T, Claus D, Weis M. Heart rate analysis in 24 patients treated with 150 mg amitriptyline per day. Psychopharmacology (Berl). 1994;116:110–4.Google Scholar
  238. Rechlin T, Weis M, Bleichner F, Joraschky P. Alterations of autonomic cardiac control in anorexia nervosa. Biol Psychiatry. 1998;43:358–63.PubMedGoogle Scholar
  239. Reed KE, Warburton DE, Whitney CL, McKay HA. Differences in heart rate variability between Asian and Caucasian children living in the same Canadian community. Appl Physiol Nutr Metab. 2006;31:277–82.PubMedGoogle Scholar
  240. Richardson T, Rozkovec A, Thomas P, Ryder J, Meckes C, Kerr D. Influence of caffeine on heart rate variability in patients with long-standing type 1 diabetes. Diabetes Care. 2004;27:1127–31.PubMedGoogle Scholar
  241. Richardson T, Baker J, Thomas PW, Meckes C, Rozkovec A, Kerr D. Randomized control trial investigating the influence of coffee on heart rate variability in patients with ST-segment elevation myocardial infarction. QJM. 2009;102:555–61.PubMedGoogle Scholar
  242. Richman JS, Moorman JR. Physiological time-series analysis using approximate entropy and sample entropy. Am J Physiol Heart Circ Physiol. 2000;278:H2039–2049.PubMedGoogle Scholar
  243. Risk M, Bril V, Broadbridge C, Cohen A. Heart rate variability measurement in diabetic neuropathy: review of methods. Diabetes Technol Ther. 2001;3:63–76.PubMedGoogle Scholar
  244. Ritto PA, Alvarado-Gil JJ, Contreras JG. Scaling and wavelet-based analysis of the long-term heart rate variability of the eastern oyster. ArXiv: physics/ 0411087 v1. 2004.Google Scholar
  245. Riznyk L, Fijalkowska M, Przesmycki K. Effects of thiopental and propofol on heart rate variability during fentanyl based induction of general anesthesia. Pharmacol Rep. 2005;57:128–34.PubMedGoogle Scholar
  246. Robert JJ, Orr WC, Elsenbruch S. Modulation of sleep quality and autonomic functioning by symptoms of depression in women with irritable bowel syndrome. Dig Dis Sci. 2004;49:1250–8.PubMedGoogle Scholar
  247. Sacre JW, Jellis CL, Marwick TH, Coombes JS. Reliability of heart rate variability in patients with type 2 diabetes mellitus. Diabet Med. 2012;29:e33–40.PubMedGoogle Scholar
  248. Saeki Y, Atogami F, Rakahashi K, Yoshizawa T. Reflex control of autonomic function induced by posture change during the menstrual cycle. J Auton Nerv Syst. 1997;66:69–74.PubMedGoogle Scholar
  249. Sandercock GR, Bromley PD, Brodie DA. The reliability of short-term measurements of heart rate variability. Int J Cardiol. 2005;103:238–47.PubMedGoogle Scholar
  250. Sanderson JE, Yeung LY, Chan S, Tomlinson B, Kay R, Woo KS, Bernardi L. Effect of beta-blockade on baroreceptor and autonomic function in heart failure. Clin Sci (Lond). 1999;96:137–46.Google Scholar
  251. Sasaki T, Iwasaki K, Oka T, Hisanga N, Ueda T, Takada Y, Fujiki Y. Effect of working hours on cardiovascular nervous functions in engineers in an electronic manufacturing company (sic!). Ind Health. 1999;37:55–61.PubMedGoogle Scholar
  252. Sasano N, Vesely AE, Hayano J, Sasano H, Somogyi R, Preiss D, Miyasaka K, Katsuya H, Iscoe S, Fisher JA. Direct effect of Pa(CO2) on respiratory sinus arrhythmia in conscious humans. Am J Physiol. 2002;282:H973–6.Google Scholar
  253. Sato N, Miyake S. Cardiovascular reactivity to mental stress: relationship with menstrual cycle and gender. J Physiol Anthropol Appl Human Sci. 2005;23:215–23.Google Scholar
  254. Schäfer A, Vagedes J. How accurate is pulse rate variability as an estimate of heart rate variability?: a review on studies comparing photoplethysmographic technology with an electrocardiogram. Int J Cardiol. 2013;166:15–29.PubMedGoogle Scholar
  255. Schipke JD, Pelzer M. Effect of immersion, submersion and scuba diving on heart rate variability. Br J Sports Med. 2001;35:174–80.PubMedGoogle Scholar
  256. Schmidt G, Malik M, Barthel P, Schneider R, Ulm K, Rolnitzky L, Camm AJ, Bigger Jr JT, Schömig A. Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet. 1999;353:1390–6.PubMedGoogle Scholar
  257. Schroeder EB, Liao D, Chambless LE, Prineas RJ, Evans GW, Heiss G. Hypertension, blood pressure, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) study. Hypertension. 2003;42:1106–11.PubMedGoogle Scholar
  258. Schroeder EB, Whitsel EA, Evans GW, Prineaas RJ, Chambless LE, Heiss G. Repeatability of heart rate variability measures. J Electrocardiol. 2004;37:163–72.PubMedGoogle Scholar
  259. Schuit AJ, van Amelsvoort LG, Verheij TC, Rijneke RD, Maan AC, Swenne CA, Schouten EG. Exercise training and heart rate variability in older people. Med Sci Sports Exerc. 1999;31:816–21.PubMedGoogle Scholar
  260. Schumacher A. Linear and nonlinear approaches to the analysis of R-R interval variability. Biol Res Nurs. 2004;5:211–21.PubMedGoogle Scholar
  261. Schwab JO, Eichner G, Veit G, Schmitt H, Lewalter T, Lüderitz B. Influence of basic heart rate and sex on heart rate turbulence in healthy subjects. Pacing Clin Electrophysiol. 2004a;27:1625–31.PubMedGoogle Scholar
  262. Schwab JO, Shlevkov N, Grunwald K, Schrickel JW, Yang A, Lickfett L, Lewalter T, Lüderitz B. Influence of the point of origin on heart rate turbulence after stimulated ventricular and atrial premature beats. Basic Res Cardiol. 2004b;99:56–60.PubMedGoogle Scholar
  263. Schwab JO, Eichner G, Shlevkov N, Schrickel J, Yang A, Balta O, Lewalter T, Lüderitz B. Impact of age and basic heart rate on heart rate turbulence in healthy persons. Pacing Clin Electrophysiol. 2005;28 Suppl 1:S198–201.PubMedGoogle Scholar
  264. Scott JM, Esch BT, Shave R, Warburton DE, Gaze D, George K. Cardiovascular consequences of completing a 160-km ultramarathon. Med Sci Sports Exerc. 2009;41:26–34.PubMedGoogle Scholar
  265. Seely AJE, Macklem PT. Complex systems and the technology of variability analysis. Crit Care. 2004;8:R367–84.PubMedGoogle Scholar
  266. Segerson NM, Smith ML, Wasmund SL, Lux RL, Daccarett M, Hamdan MH. Heart rate variability measures during sinus rhythm predict cycle length entropy during atrial fibrillation. J Cardiovasc Electrophysiol. 2008;19:1031–6.PubMedGoogle Scholar
  267. Serrador JM, Finlayson HC, Hughson RL. Physical activity is a major contributor to the ultra low frequency components of heart Rate variability. Heart. 1999;82(6):e9.PubMedGoogle Scholar
  268. Sestito A, Valsecchi S, Infusino F, Sgueglia GA, Bellocci F, Zecchi P, Crea F, Lanza GA. Differences in heart rate turbulence between patients with coronary artery disease and patients with ventricular arrhythmias but structurally normal hearts. Am J Cardiol. 2004;93:1114–8.PubMedGoogle Scholar
  269. Shabalin AV, Shaposhnikova IS, Guseva IA. Effect of amiodarone on autonomic status and its efficacy in the treatment of different variants of paroxysmal atrial fibrillation. Kardiologiia. 2002;42:25–9 (Quoted by abstract).PubMedGoogle Scholar
  270. Shehab AM, Butler R, MacFadyen RJ, Struthers AD. A placebo-controlled study examining the effect of allopurinol on heart rate variability and dysrhythmia in chronic heart failure. Br J Clin Pharmacol. 2001;51:329–34.PubMedGoogle Scholar
  271. Shin DG, Yoo CS, Yi SH, Bae JH, Kim YJ, Park JS, Hong GR. Prediction of paroxysmal atrial fibrillation using nonlinear analysis of the R-R interval dynamics before the spontaneous onset of atrial fibrillation. Circ J. 2006;70:94–9.PubMedGoogle Scholar
  272. Siegel PB, Sperber J, Kindermann W, Urhausen A. Nonstationary time series analysis of heart rate variability. ArXiv: q-bio.QM/ 0410010 v1. 2004.Google Scholar
  273. Singh JP, Larson MG, O’Donell CJ, Levy D. Genetic factors contribute to the variance in frequency domain measures of heart rate variability. Auton Neurosci. 2001;90:122–6.PubMedGoogle Scholar
  274. Sloan RP, McCreath H, Tracey KJ, et al. RR interval variability is inversely related to inflammatory markers: the CARDIA study. Mol Med. 2007;13:178–84.PubMedGoogle Scholar
  275. Sosnowski M, Clark E, Latif S, Macfarlane PW, Tendera M. Heart rate variability fraction – a new reportable measure of 24-hour R-R interval variation. Ann Noninvasive Electrocardiol. 2005;10:7–15.PubMedGoogle Scholar
  276. Sosnowski M, Macfarlane PW, Tendera M. Determinants of a reduced heart rate variability in chronic atrial fibrillation. Ann Noninvasive Electrocardiol. 2011;16:321–6.PubMedGoogle Scholar
  277. Sridhar B, Haleagrahara N, Bhat R, Kulur AB, Avabratha S, Adhikary P. Increase in the heart rate variability with deep breathing in diabetic patients after 12-month exercise training. Tohoku J Exp Med. 2010;220:107–13.PubMedGoogle Scholar
  278. Srinivasan K, Ashok MV, Vaz M, Yeragani VK. Effect of imipramine on linear and nonlinear measures of heart rate variability in children. Pediatr Cardiol. 2004;25:20–5.PubMedGoogle Scholar
  279. Stein PK, Reddy A. Non-linear heart rate variability and risk stratification in cardiovascular disease. Indian Pacing Electrophysiol J. 2005;5:210–20.PubMedGoogle Scholar
  280. Stein K, Borer J, Hochreiter C, Devereux RB, Kligfield B. Variability of the ventricular response in atrial fibrillation and prognosis in chronic nonischemic mitral regurgitation. Am J Cardiol. 1994;74:906–11.PubMedGoogle Scholar
  281. Stein PK, Rottman JN, Kleiger RE. Effect of 21 mg transdermal nicotine patches and smoking cessation on heart rate variability. Am J Cardiol. 1996;77:701–5.PubMedGoogle Scholar
  282. Stein PK, Freedland KE, Skala JA, Carney RM, Davila-Roman V, Rich MW, Kleiger RE. Heart rate variability is independent of age, gender, and race in congestive heart failure with a recent acute exacerbation. Am J Cardiol. 1997a;15:511–2.Google Scholar
  283. Stein PK, Kleiger RE, Rottman JN. Differing effects of age on heart rate variability in men and women. Am J Cardiol. 1997b;80:302–5.PubMedGoogle Scholar
  284. Stein PK, Domitrovich PP, Huikuri HV, Kleiger RE, Cast Investigators. Traditional and nonlinear heart rate variability are each independently associated with mortality after myocardial infarction. J Cardiovasc Electrophysiol. 2005;16:13–20.PubMedGoogle Scholar
  285. Stolarz K, Staessen JA, Kawecka Jaszcz K, Brand E, Bianchi G, Kuznetsova T, Tikhonoff V, Thijs L, Reineke T, Babeanu S, Casiglia E, Fagard R, Filipovsky J, Peleska J, Niktin Y, Struijker-Boudier H, Grodzicki T on behalf the European project on genes in hypertension (EPOGH) Investigators. Genetic Variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion. Hypertension. 2004;44:156–62.Google Scholar
  286. Storella RJ, Wood HW, Mills KM, Kanters JK, Hojgaard MV, Holstein-Rathlou NH. Approximate entropy and point correlation dimension of heart rate variability in healthy subjects. Integr Physiol Behav Sci. 1998;3:315–20.Google Scholar
  287. Straneva-Meuse PA, Light KC, Allen MT, Golding M, Girdler SS. Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patients. J Affect Disord. 2004;79:51–61.PubMedGoogle Scholar
  288. Sztajzel J. Heart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system. Swiss Med Wkly. 2004;134:514–22.PubMedGoogle Scholar
  289. Takabatake N, Nakamura H, Minamihaba O, Inage M, Inoue S, Kagaya S, Yamaki M, Tomoike H. A novel pathophysiological phenomenon in cachexic patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163:1314–9.PubMedGoogle Scholar
  290. Tarkiainen TH, Timonen KL, Tiittanen P, Hartikainen JE, Pekkanen J, Hoek G, Ibald-Mulli A, Vanninen EJ. Stability over time of short-term heart rate variability. Clin Auton Res. 2005;15:394–9.PubMedGoogle Scholar
  291. Task Force. Task force on standardization of clinical nomenclature. Circulation. 1979;59:607–9.Google Scholar
  292. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Standards of measurement, physiological interpretation and clinical use. Circulation. 1996;93:1043–65.Google Scholar
  293. Thakre TP, Smith ML. Loss of lag-response curvilinearity of indices of heart rate variability in congestive heart failure. BMC Cardiovasc Disord. 2006;6:27. doi: 10.1186/1471-2261-6-27.PubMedGoogle Scholar
  294. Thurner S, Feurstein MC, Teich MC. ROC analysis and a realistic model of heart rate variability. ArXiv: chao-dyn/ 9806022 v1.1998a.Google Scholar
  295. Thurner S, Feurstein MC, Teich MC. Multiresolution wavelet analysis of heartbeat intervals discriminates healthy patients from those with cardiac pathology. Phys Rev Lett. 1998b;80:1544–7.Google Scholar
  296. Tingley WG, Pawlikoska L, Zaroff JG, Kim T, Nguyen T, Young SG, et al. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A. 2007;104:8461–6.PubMedGoogle Scholar
  297. Togo F, Yamamoto Y. Decreased fractal component of human heart rate variability during non-REM sleep. Am J Physiol Heart Circ Physiol. 2000;280:H17–21.Google Scholar
  298. Togo F, Kiyono K, Struzik ZR, Yamamoto Y. Unique very low-frequency heart rate variability during deep sleep in humans. IEEE Trans Biomed Eng. 2006;53:28–34.PubMedGoogle Scholar
  299. Tory K, Horváth E, Süveges Z, Fekete A, Sallay P, Berta K, Szabó T, Szabó AJ, Tulassay T, Reusz GS. Effect of propranolol on heart rate variability in patients with end-stage renal disease: a double-blind, placebo-controlled, randomized crossover pilot trial. Clin Nephrol. 2004;61:316–23.PubMedGoogle Scholar
  300. Tsai MW, Chie WC, Kuo TB, Chen MF, Liu JP, Chen TT, Wu YT. Effects of exercise training on heart rate variability after coronary angioplasty. Phys Ther. 2006;86:626–35.PubMedGoogle Scholar
  301. Tsuji H, Venditti FJ, Manders ES, Rvans JC, Larson MG, Feldman CL, Levy D. Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation. 1994;90:878–83.PubMedGoogle Scholar
  302. Tulen JH, Man in’t Veld AJ, von Roon AM, Moleman P, van Steenis HG, Blankestijn PJ, Boomsma F. Spectral analysis of hemodynamics during infusions of epinephrine and norepinephrine in men. J Appl Physiol. 1994;76:1914–21.PubMedGoogle Scholar
  303. Tuomainen P, Peuhkurinen K, Kettunen R, Rauramaa R. Regular physical exercise, heart rate variability and turbulence in a 6-year randomized controlled trial in middle-aged men: the DNASCO study. Life Sci. 2005;77:2723–34.PubMedGoogle Scholar
  304. Unoki T, Grap MJ, Sessler CN, Best AM, Wetzel P, Hamilton A, Mellott KG, Munro CL. Autonomic nervous system and depth of sedation in adults receiving mechanical ventilation. Am J Crit Care. 2009;18:42–50.PubMedGoogle Scholar
  305. Van den Berg G, Pincus SM, Veldhuis JD, Frölich M, Roelfsema F. Greater disorderliness of ACTH and cortisol release accompanies pituitary-dependent Cushing’s disease. Eur J Endocrinol. 1997a;136:394–400.PubMedGoogle Scholar
  306. Van den Berg MP, Haaksma J, Brouwer J, Tieleman RG, Mulder G, Crijns HJ. Heart rate variability in patients with atrial fibrillation is related to vagal tone. Circulation. 1997b;19:1209–16.Google Scholar
  307. Van den Berg J, Neely G, Wiklund U, Landstrom U. Heart rate variability during sedentary work and sleep in normal and sleep-deprived states. Clin Physiol Funct Imaging. 2005;25:51–7.PubMedGoogle Scholar
  308. Van Roon AM, Mulder LJM, Veldmann JBP, Mulder G. Beat-to-beat blood-pressure measurements applied on studies on mental workload. Homeostasis. 1995;36:316–24.Google Scholar
  309. Van Roon AM, Mulder LJM, Althaus M, Mulder G. Introducing a baroreflex model for studying cardiovascular effects of mental workload. Psychophysiology. 2004;41:961–81.PubMedGoogle Scholar
  310. Varela M, Jimenez L, Farina R. Complexity analysis of the temperature curve: new information from body temperature. Eur J Appl Physiol. 2003;89:230–7.PubMedGoogle Scholar
  311. Velez-Roa S, Renard M, Degaute JP, von de Borne P. Peripheral sympathetic control during dobutamine infusion: effects of aging and heart failure. J Am Coll Cardiol. 2003;42:1605–10.PubMedGoogle Scholar
  312. Veltman JA, Gaillard AWK. Indices of mental workload in a complex task environment. Neuropsychobiology. 1993;28:72–5.PubMedGoogle Scholar
  313. Veltman JA, Gaillard AWK. Physiological workload reactions to increasing levels of task difficulty. Ergonomics. 1998;41:656–69.PubMedGoogle Scholar
  314. Vettorello M, Colombo R, De Grandis CE, Constantini E, Raimondi F. Effect of fentanyl on heart rate variability during spontaneous and paced breathing in healthy volunteers. Acta Anaesthesiol Scand. 2008;52:1064–70.PubMedGoogle Scholar
  315. Vigo DE, Nicola SL, Ladron de Guevara MS, Martinez-Martinez JA, Fahrer RD, Ccardinali DP, Masoli O, Guinjoan SM. Relation of depression to heart rate nonlinear dynamics in patients > or = 60 years of age with recent unstable angina pectoris or acute myocardial infarction. Am J Cardiol. 2004;93:756–60.PubMedGoogle Scholar
  316. Vikman S, Mäkikallio TH, Yli-Mäyry S, Pikkujämsä S, Koivisto AM, Reinikainen P. Altered complexity and correlation properties of R-R interval dynamics before the spontaneous onset of paroxysmal atrial fibrillation. Circulation. 1999;100:2079–84.PubMedGoogle Scholar
  317. Viola AU, Simon C, Eherhart J, Geny B, Piquart F, Muzet A, Brandenberger G. Sleep processes exert a predominant influence on the 24-h profile of heart rate variability. J Biol Rhythms. 2002;17:539–47.PubMedGoogle Scholar
  318. Vögele C, Hilbert A, Tuschen-Caffier B. Dietary restriction, cardiac autonomic regulation and stress reactivity in bulimic women. Physiol Behav. 2009;98:229–34.PubMedGoogle Scholar
  319. Wali R, Weir M. Hypertensive cardiovascular disease in African-Americans. Curr Hypertens Rep. 1999;1:521–8.PubMedGoogle Scholar
  320. Weber CS, Thayer JF, Rudat M, Wirtz PH, Zimmermann-Viehoff F, Thomas A, Perschel FH, Arck PC, Deter HC. Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers. Eur J Appl Physiol. 2010;109:201–11.PubMedGoogle Scholar
  321. Weippert M, Arndt D, Kreuzfeld S, Stoll R. Herzfrequenzmessung mit unterschiedlichen Geräten – Auswirkungen auf das HRV-Frequenzspektrum. In: Hottenrott K, editor. Herzfrequenzvariabilität im Fitness und Gesundheitssport, vol. 142. Hamburg: Schriften der Deutschen Vereinigung für Sportwissenschaft Czwalina Verlag; 2004. p. 152–9.Google Scholar
  322. Wessel N, Schumann A, Schirdewan A, Voss A, Kurths J. Entropy measures in heart Variability Data. Lect Notes Comput Sci. 2000;1993:78–87.Google Scholar
  323. Wichterle D, Simek J, La Rovere MT, Schwartz PJ, Camm AJ, Malik M. Prevalent low-frequency oscillation of heart rate: novel predictor of mortality after myocardial infarction. Circulation. 2004;110:1183–90.PubMedGoogle Scholar
  324. Wissel C. An universal law of characteristic return time near thresholds. Oecologia. 1984;65:101–7.Google Scholar
  325. Wittling W, Wittling RA. Herzschlagvariabilität: Frühwarnsystem, Stress- und Fitnessindikator. Eichsfeld-Verlag Heiligenstadt; 2012.Google Scholar
  326. Wolf A, Swift JB, Swinney LH, Vastano JA. Determining Lyapunov exponent from a time series. Physica D. 1985;16:285–317.Google Scholar
  327. Woo MA, Stevenson WG, Moser DK, Trelease RB, Harper RM. Patterns of beat-to-beat heart rate variability in advanced heart failure. Am Heart J. 1992;123:704–10.PubMedGoogle Scholar
  328. Wright CE, Kuny-Ebrecht SR, Iliffe S, Foese O, Streptoe A. Physiological correlates of cognitive functioning in an elderly population. Psychoneuroendocrinology. 2005;30:826–38.PubMedGoogle Scholar
  329. Yamamoto Y, Hughson RK. Coarse-graining spectral analysis: new method for studying heart rate variability. J Appl Physiol. 1991;71:1143–50.PubMedGoogle Scholar
  330. Yamamoto Y, Hughson RL. On the fractal nature of heart rate variability in humans: effects of data length and beta-adrenergic blockade. Am J Physiol. 1994;266:R40–9.PubMedGoogle Scholar
  331. Yamamoto Y, Houghson RL, Nakamura Y. Autonomic nervous system responses to exercise in relation to ventilatory threshold. Chest. 1992;101:206S–10.PubMedGoogle Scholar
  332. Yasumo F, Hayano JI. Impact of acute hypoxia on heart rate and blood pressure variability in conscious dogs. Am J Physiol Heart Circ Physiol. 2000;279:H2344–9.Google Scholar
  333. Yeragani VK, Pohl R, Mallavarapu M, Balon R. Approximate entropy of symptoms of mood: an effective technique to quantify regularity of mood. Bipolar Disord. 2003;5:279–86.PubMedGoogle Scholar
  334. Yeragani VK, Rao R, Tancer M, Uhde T. Paroxetine decreases respiratory irregularity of linear and nonlinear measures of respiration in patients with panic disorder. A preliminary report. Neuropsychobiology. 2004;49:53–7.PubMedGoogle Scholar
  335. Yeragani VK, Krishnan S, Engels HJ, Gretebeck R. Effects of caffeine on linear and nonlinear measures of heart rate variability before and after exercise. Depress Anxiety. 2005;21:130–4.PubMedGoogle Scholar
  336. Yi CH, Chen CL, Kuo TB, Yang CC. The effect of acid suppression on sleep and cardiac autonomic regulation in GERD. Hepatogastroenterology. 2008;55:1649–52.PubMedGoogle Scholar
  337. Yoshiuchi K, Quigley KS, Ohashi K, Yamamoto Y, Natelson BH. Use of time-frequency analysis to investigate temporal patterns of cardiac autonomic response during head-up tilt in chronic fatigue syndrome. Auton Neurosci. 2004;113:55–62.PubMedGoogle Scholar
  338. Yue W, Schneider A, Ruckerl R, et al. Relationship between electrocardiographic and biochemical variables in coronary artery disease. Int J Cardiol. 2007;119:185–91.PubMedGoogle Scholar
  339. Yulmetyev RM, Demin SA, Panischev OY. Age-related alterartions of relaxation processes and non-Markov effects in stochastic dynamics of R-R intervals variability from human ECGs. ArXiv: physics/ 0603028 v1. 2006.Google Scholar
  340. Zhang HX, Zhu YS, Wang ZM. Complexity measure and complexity rate information based detection of ventricular tachycardia and fibrillation. Med Biol Eng Comput. 2000;38:553–7.Google Scholar
  341. Zheng JH, Chen J, Arendt-Nielsen L. Complexity of tissue injury-induced nociceptive discharge of dorsal horn wide dynamic range neurons in the rat, correlation with the effect of systemic morphine. Brain Res. 2004;1001:143–9.PubMedGoogle Scholar
  342. Zhong X, Hilton HJ, Gates GJ, Stern Y, Bartels MN, Demeersman RE, Basner RC. Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. J Appl Physiol. 2005;98:2024–32.PubMedGoogle Scholar

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© Springer-Verlag London 2014

Authors and Affiliations

  1. 1.Kongsberg HospitalKongsbergNorway

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