The Discovery of HLA-B27 in Ankylosing Spondylitis and Related Disorders

  • Alan Ebringer
  • Alan Ebringer


In the early 1970s, following Dr. Christian Barnard’s momentous first cardiac transplantation in the world, the field of organ transplantation acquired a new resonance, and tissue typing units were formed in many hospitals.


Rheumatoid Arthritis Patient Ankylose Spondylitis Rheumatic Fever Molecular Mimicry Reactive Arthritis 
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  1. Aho K, Ahvonen P, Lassus A, Sievers K, Tiilikainen A. HL-A in reactive arthritis. A study of Yersinia arthritis and Reiter’s disease. Arthritis Rheum. 1974;17:521–6.PubMedCrossRefGoogle Scholar
  2. Brewerton DA, Hart FD, Nicholls A, Caffrey M, James DCO, Sturrock RD. Ankylosing spondylitis and HL-A 27. Lancet. 1973a;i:904–7.CrossRefGoogle Scholar
  3. Brewerton DA, Nicholls A, Caffrey M, Walters D, James DCO. Acute anterior uveitis and HL-A 27. Lancet. 1973b;ii:994–6.CrossRefGoogle Scholar
  4. Brewerton DA, Nicholls A, Oates JK, Caffrey M, Walters D, James DCO. Reiter’s disease and HL-A 27. Lancet. 1973c;ii:996–8.CrossRefGoogle Scholar
  5. Caffrey MFP, James DCO. Human lymphocyte antigen association in ankylosing spondylitis. Nature. 1973;242:121.Google Scholar
  6. Ebringer A, Davies DAL. Crossreactivity between synthetic TGAL and transplantation antigens in CBA mice. Nature (New Biol). 1973;74:144–7.Google Scholar
  7. Gofton JP, Chalmers A, Price GE, Reeve CE. HLA 27 and ankylosing spondylitis in B.C. Indians. J Rheumatol. 1975;2:166–8.Google Scholar
  8. James DCO. HLA-B27 in clinical medicine – historical reflections on the discovery of the disease association. Br J Rheumatol. 1983;22 Suppl 2:20–4.PubMedCrossRefGoogle Scholar
  9. Khan M. Genetics of HLA-B27. Br J Rheumatol. 1988;27 Suppl 2:6–11.PubMedCrossRefGoogle Scholar
  10. Khan M. A worldwide overview: the epidemiology of HLA-B27 and associated spondyloarthritides. In: Calin A, Taurog JD, editors. The spondyloarthritides. Oxford: Oxford University Press; 1998. p. 17–26.Google Scholar
  11. Schlosstein L, Terasaki PI, Bluestone R, Pearson CM. High association of an HLA antigen W27, with ankylosing spondylitis. N Engl J Med. 1973;288:704–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Alan Ebringer
    • 1
  • Alan Ebringer
    • 2
    • 3
  1. 1.King’s College LondonLondonUK
  2. 2.UCH School of MedicineMiddlesex HospitalLondonUK
  3. 3.Division of Life SciencesKing’s College LondonLondonUK

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