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Pelvic Cancer Surgery pp 217–224Cite as

Management of Erectile Dysfunction After Radical Prostatectomy

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Abstract

Erectile dysfunction (ED) is one of the most common sequelae after radical prostatectomy for organ-confined prostate cancer. Despite nerve-sparing techniques, surgical neurovascular injury occurs and subsequent cessation of erections leads to significant cavernosal hypoxia with attendant microstructural consequences and severe impairment of erectile function (EF). Pharmacological strategies for rehabilitation of natural EF using on demand or daily phosphodiesterase type 5-inhibitors (PDE5i) have not proven to positively impact the return of unassisted EF in randomized controlled trials.

However, treatment-options for ED are available including oral, intracavernosal, or intraurethral therapy, vacuum devices, and ultimately penile implant surgery.

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Author information

Authors and Affiliations

  1. Male Sexual and Reproductive Medicine Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    John P. Mulhall MD, FECSM

  2. Department of Men’s Health, Eli Lilly & Company, Indianapolis, IN, USA

    Craig F. Donatucci MD

  3. Male Reproductive Medicine and Microsurgery, Department of Urology, Weill Cornell Medical College, New York, NY, USA

    Kelly A. Chiles MD, MSc

  4. Medical Department, Men’s Health ACE (Australia, Canada, Europe), Lilly Deutschland GmbH, Bad Homburg v.d.H., Germany

    Hartwig Büttner MD, FECSM

Authors
  1. John P. Mulhall MD, FECSM
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  2. Craig F. Donatucci MD
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  3. Kelly A. Chiles MD, MSc
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  4. Hartwig Büttner MD, FECSM
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Corresponding author

Correspondence to Hartwig Büttner MD, FECSM .

Editor information

Editors and Affiliations

  1. Urology, University Hospital of North Norway, Tromsø, Norway

    Hitendra R.H. Patel

  2. University College London Hospital, London, United Kingdom

    Tim Mould

  3. Laparoscopic and Robotic Surgery, University of Rochester Medical Center, Rochester, New York, USA

    Jean V. Joseph

  4. Colorectal Surgery, University Hospitals Case Medical Center, Cleveland, Ohio, USA

    Conor P. Delaney

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© 2015 Springer-Verlag London

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Mulhall, J.P., Donatucci, C.F., Chiles, K.A., Büttner, H. (2015). Management of Erectile Dysfunction After Radical Prostatectomy. In: Patel, H., Mould, T., Joseph, J., Delaney, C. (eds) Pelvic Cancer Surgery. Springer, London. https://doi.org/10.1007/978-1-4471-4258-4_22

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  • DOI: https://doi.org/10.1007/978-1-4471-4258-4_22

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-4257-7

  • Online ISBN: 978-1-4471-4258-4

  • eBook Packages: MedicineMedicine (R0)

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