Blueberry-Muffin Lesions in a Baby

  • Mohammad Ali El-Darouti


A 4-month-old male, delivered at full term after uncomplicated pregnancy. The baby had poor feeding, diarrhea, dehydration, and failure to thrive. His skin showed multiple randomly distributed bluish subcutaneous nodules on the trunk (Fig. 92.1). The nodules exhibited blanching response to palpation. The lesions evolved in 4 weeks.


Anaplastic Lymphoma Kinase Leukocyte Common Antigen Vanillyl Mandelic Acid Small Round Blue Cell Tumor Metastatic Neuroblastoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Brodeur GM. Molecular pathology of human neuroblastomas. Semin Diagn Pathol. 1994;11(2):118–25.PubMedGoogle Scholar
  2. Carlsen NL. Neuroblastoma: epidemiology and pattern of regression. Problems in interpreting results of mass screening. Am J Pediatr Hematol Oncol. 1992;14(2):103–10.PubMedCrossRefGoogle Scholar
  3. Coldman AJ, et al. Neuroblastoma: influence of age at diagnosis, stage, tumor site, and sex on prognosis. Cancer. 1980;46:1896–901.PubMedCrossRefGoogle Scholar
  4. Fish JD, Grupp SA. Stem cell transplantation for neuroblastoma. Bone Marrow Transplant. 2008;41(2):159–65.PubMedCrossRefGoogle Scholar
  5. George RE, London WB, Cohn SL, et al. Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a pediatric oncology group study. J Clin Oncol. 2005;23(27):6466–73.PubMedCrossRefGoogle Scholar
  6. Gray JC, Kohler JA. Immunotherapy for neuroblastoma: turning promise into reality. Pediatr Blood Cancer. 2009;53:931–40.PubMedCrossRefGoogle Scholar
  7. Ishola TA, Chung DH. Neuroblastoma. Surg Oncol. 2007;16:149–56.PubMedCrossRefGoogle Scholar
  8. Look AT, Hayes FA, Shuster JJ, et al. Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a pediatric oncology group study. J Clin Oncol. 1991;9(4):581–91.PubMedGoogle Scholar
  9. Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet. 2007;369(9579):2106–20.PubMedCrossRefGoogle Scholar
  10. Massaron S, Seregni E, Luksch R, et al. Neuron-specific enolase evaluation in patients with neuroblastoma. Tumour Biol. 1998;19(4):261–8.PubMedCrossRefGoogle Scholar
  11. Mopett J, Haddadin I, Foot ABM. Neonatal neuroblastoma. Arch Dis Child Fetal Neonatal Ed. 1999;81:134–337.CrossRefGoogle Scholar
  12. Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008;455(7215):930–5.PubMedCrossRefGoogle Scholar
  13. Schulte JH, Horn S, Schlierf S, et al. MicroRNAs in the pathogenesis of neuroblastoma. Cancer Lett. 2009;274:10–5.PubMedCrossRefGoogle Scholar
  14. Seeger RC, Siegel SE, Sidell N. Neuroblastoma: clinical perspectives, monoclonal antibodies, and retinoic acid. Ann Intern Med. 1982;97(6):873–84. ID – CA 22794/CA/NCI.PubMedGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  • Mohammad Ali El-Darouti
    • 1
  1. 1.Cairo UniversityCairoEgypt

Personalised recommendations