Human Neural Stem Cell Transplants in Neurological Disorders: Current Trends and Future Options

  • Abhijit Chaudhuri
  • Niranjan Bhattacharya


Loss of neurons and glial cells is a common neuropathology in human neurological diseases. From acute stroke to chronic central nervous system (CNS) disorders like Parkinson’s disease and Alzheimer’s disease, neuronal and glial cell death and damage remain irreparable with existing therapies. During the past decade, cell replacement therapy, gene transfer, and selective repair of injured neural cells in diseased areas of human brain and experimental animal models have become active areas of research with potential for promising therapeutic developments in neurological diseases.


Amyotrophic Lateral Sclerosis Motor Neuron Disease Neuronal Ceroid Lipofuscinosis Neural Stem Cell Transplant Human Neurological Disease 
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  1. 1.
    Lindvall O, Kokaia Z. Stem cells for treatment of neurological disorders. Nature. 2006;441:1094–6.PubMedCrossRefGoogle Scholar
  2. 2.
    Piccini P, et al. Factors affecting the clinical outcome after neural transplantation in Parkinson’s disease. Brain. 2005;128:2977–86.PubMedCrossRefGoogle Scholar
  3. 3.
    Hagell P, Brundin P. Cell survival and clinical outcome following intrastriatal transplantation in Parkinson’s disease. J Neuropathol Exp Neurol. 2002;60:741–52.Google Scholar
  4. 4.
    Samanta BK. A study of foetal neuronal tissue graft in a heterotopic transplantation site and its implications. PhD thesis, Jadavpur University, Kolkata; 2009.Google Scholar
  5. 5.
    Rita Nodari L, et al. Long term survival of human neural stem cells in the ischaemic rat brain upon transient immunosuppression. PLoS One. 2010;5:e14035.CrossRefGoogle Scholar
  6. 6.
    Bachoud-Levi AC, et al. Motor and cognitive improvements in patients with Huntington’s disease after neural transplantation. Lancet. 2000;356:1975–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Pluchino S, et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature. 2003;422:688–94.PubMedCrossRefGoogle Scholar
  8. 8.
    Chu K, et al. Combined treatment of vascular endothelial growth factor and human stem cells in experimental focal cerebral ischaemia. Neurosci Res. 2005;53:384–90.PubMedCrossRefGoogle Scholar
  9. 9.
    Jeong SW, et al. Human neural stem cell transplantation in experimental cerebral haemorrhage. Stroke. 2003;34:2258–63.PubMedCrossRefGoogle Scholar
  10. 10.
    Cummings G, et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci USA. 2005;102:14069–74.PubMedCrossRefGoogle Scholar
  11. 11.
    Hofsletter CP, et al. Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci. 2005;8:346–53.CrossRefGoogle Scholar
  12. 12.
    Kim SU, de Vellis J. Stem cell-based therapy in neurological diseases: a review. J Neurosci Res. 2009;87:2183–200.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag London 2013

Authors and Affiliations

  1. 1.Department of NeurologyEssex Centre for Neurological Sciences, Queen’s HospitalRomfordUK
  2. 2.Department of Regenerative Medicine and Translational ScienceCalcutta School of Tropical MedicineCalcuttaIndia

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