While a corneal transplant is the most advantageous form of homograft, success cannot always be guaranteed and we are now entering the era of repeated procedures and these have a progressively worse prognosis for visual outcome (Patel et al. 2000). Initially, excised host corneal tissue, optimally fixed, provided an excellent opportunity for the morphological and histochemical study of common and rare causes of corneal opacification and this was also relevant to the future management of a patient suffering from bilateral disease. At the present time the clinical diagnosis is frequently accurate and it might be argued that histopathology is not necessary in every routine case. However, there is still a good argument for routine examination of keratoplasty discs even though there is a confident clinical diagnosis. For example, heavily inflamed and vascularised tissue detected in the excised cornea indicates the presence of a similar process in the surrounding corneal rim of the recipient bed and this enhances the risk of immune rejection.
KeywordsAmniotic Membrane Corneal Endothelium Corneal Stroma Corneal Dystrophy Acanthamoeba Keratitis
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