Genetic Aspects of the Hypermobility Syndrome

  • Peter Beighton
  • Rodney Grahame
  • Howard Bird


The term hypermobility syndrome (HMS) was coined to denote the presence of rheumatic symptoms with generalised joint laxity, in the absence of any demonstrable systemic rheumatic disease (Kirk et al. 1967). Of 9275 consecutive patients attending the rheumatology clinic at Guy’s Hospital, 2% were diagnosed as suffering from HMS. Of these, 85% were female (see Chap. 6). A similar prevalence (1.7%) has been seen among 690 new referrals to a paediatric rheumatology centre (Ansell 1972).


Osteogenesis Imperfecta Collagen Gene Marfan Syndrome Connective Tissue Disorder Mitral Valve Prolapse 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Peter Beighton
    • 1
  • Rodney Grahame
    • 2
  • Howard Bird
    • 3
  1. 1.MRC Research Unit for Inherited Skeletal Disorders, Medical School and Groot Schuur HospitalUniversity of Cape TownSouth Africa
  2. 2.Rheumatology Unit, Division of Medicine, United Medical and Dental SchoolsGuy’s HospitalLondonUK
  3. 3.Royal Bath HospitalUniversity of Leeds, and Clinical Pharmacology Unit (Rheumatism Research)HarrogateUK

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