Abstract
Recent data have shown that, among the possible mediators of the pathophysiological mechanisms responsible for atherogenesis in vivo, cytokines may play a major role.1 Cytokines are secreted proteins that have been initially identified as products of fibroblasts or leukocytes; they act as intercellular signals regulating the function of different cell types and, particularly, their proliferation and differentiation. Figure 1 summarizes the different families of cytokines that have been identified. Nine different types of interleukins (IL) have been isolated so far, as well as two different tumor necrosis factors (TNF) and a variety of other substances such as colony stimulating factors, interferons, transforming growth factors (TGF) and platelet derived growth factors (PDGF).
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References
Cotran R.S., Pober J.S.: Effects of cytokines on vascular endothelium: Their role in vascular and immune injury. Kidney Internat. 1989; 35: 969–75
Dinarello C.A.: Interleukin-1. Rev. Infect. Dis. 1988; 10: 168–89
Warner S.J.C., Auger K.R., Libby P.: Human interleukin-1 induces interleukin-1 gene expression in human vascular smooth muscle cells. J. Exp. Med. 1987; 165: 1316–21
Barath P., Fishbein M.C., Cao J., Berenson J., Helfant R.H., Forrester J.S.: Detection and localisation of tumor necrosis factor in human atheroma. Am. J. Cardiol. 1990; 65: 297–302
Endres S., Ghorbani R., Kelley V.E., Georgilis K., Lonnemann G., van der Meer J.W.M., Cannon J.G., Rogers T.S., Klempner M.S., Weber P.C., Schaefer E.J., Wolff S.M., Dinarello C.A.: The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N. Engl. J. Med. 1989; 320: 26571
Meydani S.N., Endres S., Woods M.M. et al.: Oral n-3 fatty acid supplementation suppresses cytokine production and lymphocyte proliferation: comparison in young and older women. J. Nutrition 1991; 121: 547–55
Renz H., Gong J.H., Schmidt A., Nain M., Gemsa D.: Release of tumor necrosis factor from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides. J. Immunol. 1988; 141: 2388–93
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© 1992 Springer-Verlag London
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Endres, S. (1992). Cytokines and their Modulation by n-3 Fatty Acids with Regard to Atherogenesis. In: De Caterina, R., Kristensen, S.D., Schmidt, E.B. (eds) Fish Oil and Vascular Disease. Current Topics in Cardiovascular Diseases. Springer, London. https://doi.org/10.1007/978-1-4471-3890-7_9
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DOI: https://doi.org/10.1007/978-1-4471-3890-7_9
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