The Effect of n-3 Fatty Acids on Blood Coagulation

  • G. Hornstra
Part of the Current Topics in Cardiovascular Diseases book series (2943)


Blood coagulation is likely to play an important role in development and complications of ischaemic heart and vessel disease. This is indicated by the fact that the atherosclerotic plaque contains fibrin,1 the end product of the coagulation cascade. Moreover, oral anticoagulants appeared to be effective in the secondary prevention of myocardial infarction.2 Finally, there is strong epidemiological evidence that increased plasma levels of certain coagulation factors are associated with a higher risk of cardiovascular mortality.3,4


Activate Partial Thromboplastin Time Plasma Fibrinogen Dietary Fish Activate Blood Platelet High Saturated Fatty Acid Content 
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  1. 1.
    Woolf, N.: Pathology of Atherosclerosis. Thrombosis and atherosclerosis. London, Butterworth Scientific 1982; 217–259Google Scholar
  2. 2.
    Vries W.A., de Tijssen J.P.G., Loeliger E.A., Roos J.: A double-blind trial to assess long-term anticoagulant therapy in elderly patients after myocardial infarction. Lancet 1980; 2: 989–994Google Scholar
  3. 3.
    Wilhelmsen L., Svardsudd K., Korsan-Bengtsen K., Larsson B., Welin L., Tibblin G.: Fibrinogen as a risk factor for stroke and myocardial infarction. New. Engl. J. Med. 1984; 311: 501–505PubMedCrossRefGoogle Scholar
  4. 4.
    Meade T.W., Brozovic M., Chakrabarti R.R., Hannes A.P., Imeson J.D., Mellows S., Miller G.J., North W.R.S., Stirling Y., Thompson S.G.: Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 2: 533–537PubMedCrossRefGoogle Scholar
  5. 5.
    Bevers E.M., Rosing J., Zwaal R.F.A.: Platelets and coagulation. In: Maclntyre D.E., Gordon J. (Eds.): Platelets in Biology and Pathology III. Amsterdam, Elsevier Science Publishers, B.V. Biomedical Division 1987; 127–160Google Scholar
  6. 6.
    Davey M.G., Luscher E.F.: Actions of thrombin and other coagulant and proteolytic enzymes on blood platelets. Nature 1967; 216: 857–858PubMedCrossRefGoogle Scholar
  7. 7.
    Rosenberg R.D., Rosenberg J.S.: Natural anticoagulant mechanisms. J. Clin. Invest. 1984; 74: 16CrossRefGoogle Scholar
  8. 8.
    Broekmans A.W., Veltkamp J.J., Bertina R.M.: Congenital protein C deficiency and venous thromboembolism. A study in three Dutch families. New. Engl. J. Med. 1983; 309: 340–344PubMedCrossRefGoogle Scholar
  9. 9.
    Hornstra G.: Dietary fats, prostanoids and arterial thrombosis. Chapter 7: Effect offish oil feeding on arterial thrombosis, platelet function and blood coagulation. The Hague, Martinus Nijhoff Publishers, 1982; 106–137CrossRefGoogle Scholar
  10. 10.
    Dyerberg J., Bang H.O.: Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. Lancet 1979; 2: 433–435PubMedCrossRefGoogle Scholar
  11. 11.
    Jorgensen K.A., Nielsen A.H., Dyerberg J.: Hemostatic factors and renin in Greenland Eskimos on a high eicosapentaenoic acid intake. Acta Med. Scand. 1986; 219: 473–479Google Scholar
  12. 12.
    Schmidt E.B., Sorensen P.J., Ernst E., Kristensen S.D., Pedersen J.O., Dyerberg J.: Studies on coagulation and fibrinolysis in Greenland Eskimos. Thromb. Res. 1989; 56: 553–558PubMedCrossRefGoogle Scholar
  13. 13.
    Stoffersen E., Jorgensen K.A., Dyerberg J.: Antithrombin III and dietary intake of polyunsaturated fatty acids. Scand. J. Clin. Lab. Invest. 1982; 42: 83–86PubMedCrossRefGoogle Scholar
  14. 14.
    Dyerberg J., Jorgensen K.A.: Marine oils and thrombogenesis. Progr. Lip. Res. 1982; 21: 255–269CrossRefGoogle Scholar
  15. 15.
    Terano T., Hirai A., Hamazaki T., Kobayashi S., Fujita T., Tamura Y., Kumagai A.: Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformability in healthy human subjects. Atherosclerosis 1983; 46: 321–331PubMedCrossRefGoogle Scholar
  16. 16.
    Dehmer G.J., Popma J.J., van den Berg E.K., Eichhorn E.J., Prewitt J.B., Campbell W.B., Jennings L., Willerson J.T., Schmitz J.M.: Reduction in the rate of early restenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids. New Engl. J. Med. 1988; 319: 733–740Google Scholar
  17. 17.
    Lox C.D.: The effects of dietary marine fish oils (omega-3 fatty acids) on coagulation profiles in men. Gen. Pharmac. 1990; 21: 241–246CrossRefGoogle Scholar
  18. 18.
    Muller A.D., van Houwelingen A.C., van Dam-Mieras M.C.E., Bas B.M., Hornstra G.: Effect of a moderate fish intake on haemostatic parameters in healthy males. Thromb. Haemost. 1989; 61: 468–473PubMedGoogle Scholar
  19. 19.
    Thorngren M., Gustafson A.: Effects of 11-week increase in dietary eicosapentaenoic acid on bleeding time, lipids and platelet aggregation. Lancet 1981; 2: 1190–1193PubMedCrossRefGoogle Scholar
  20. 20.
    Yoshimura T, Matsui K., Yunohara T., Kawasaki N., Nakamura T., Okamura H.: Effects of highly purified eicosapentaenoic acid on plasma beta thromboglobulin level and vascular reactivity to angiotensin II. Artery 1987: 14: 295–303PubMedGoogle Scholar
  21. 21.
    Mortensen J.Z., Schmidt E.B., Nielsen A.H., Dyerberg J.: The effect of (n-6) and (n-3) polyunsaturated fatty acids on haemostasis, blood lipids and blood pressure. Thromb. Haemostas. 1983; 50: 543–546Google Scholar
  22. 22.
    Schmidt E.B., Kristensen S.D., Dyerberg J.: The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris. Artery 1988; 15: 316–329PubMedGoogle Scholar
  23. 23.
    Brox J.H., Killie J.E., Gunnes S., Nordoy A.: The effect of cod-liver oil and corn oil on platelets and vessel wall in man. Thromb. Haemostas. 1981; 46: 604–611Google Scholar
  24. 24.
    Brox J.H., Killie J.E., Q sterud B., Holme S., Nordoy, A.: Effects of cod liver oil on platelets and coagulation in familial hypercholesterolemia (Type IIa). Acta Med. Scand. 1983; 213: 137–144Google Scholar
  25. 25.
    Rogers S., James K.S., Butland B.K., Etherington M.D., O’Brien J.R., Jones J.G.: Effects of a fish oil supplement on serum lipids, blood pressure, bleeding time, haemostatic and rheological variables. A double blind randomised controlled trial in healthy volunteers. Atherosclerosis 1987; 63: 137–143PubMedCrossRefGoogle Scholar
  26. 26.
    Norris P.G., Jones C.J.H., Weston M.J.: Effect of dietary supplementation with fish oil on systolic blood pressure in mild essential hypertension. Brit. Med. J. 1986; 293: 104–105CrossRefGoogle Scholar
  27. 27.
    Sanders T.A.B., Vickers M., Haines A.P.: Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. Clin. Sci. 1981; 61: 317–324PubMedGoogle Scholar
  28. 28.
    Schmidt E.B., Ernst E., Varming K., Pedersen J.O., Dyerberg J.: The effect of n-3 fatty acids on lipids and haemostasis in patients with Type IIa and Type IV hyperlipidaemia. Thromb. Haemost. 1989; 62: 797–801PubMedGoogle Scholar
  29. 29.
    Schmidt E.B., Sorensen P.J., Pedersen J.O., Jersild C., Ditzel J., Grunnet N., Dyerberg J.: The effect of (n-3) polyunsaturated fatty acids on lipids, hemostasis, neutrophil and monocyte chemotaxis in insulin dependent diabetes mellitus. J. Int. Med. 225 Suppl. 1989; 1: 201–206Google Scholar
  30. 30.
    Haines A.P., Sanders T.A.B., Imeson J.D., Mahler R.F., Martin J., Mistry M., Vickers M., Wallace P.G.: Effects of a fish oil supplement on platelet function, hemostatic variables and albuminuria in insulin-dependent diabetics. Thromb. Res. 1986; 43: 643–655PubMedCrossRefGoogle Scholar
  31. 31.
    Hostmark A.T., Bjerkedal T., Kierulf P., Flaten H., Ulshagen K.: Fish oil and plasma fibrinogen. Brit. Med. J. 1988; 297: 180–181PubMedCrossRefGoogle Scholar
  32. 32.
    Radack K., Deck C., Huster G.: Dietary supplementation with low-dose fish oils lowers fibrinogen levels: a randomized. double-blind controlled study. Ann. Int. Med. 1989; 111: 757758Google Scholar
  33. 33.
    Saynor R., Gillett T.: Fish oil and plasma fibrinogen. Brit. Med. J. 1988; 297: 1196PubMedCrossRefGoogle Scholar
  34. 34.
    Hendra T.J., Britton M.E., Roper D.R., Wagaine-Twabwe D., Jeremy J.Y., Dandona P., Haines A.P., Yudkin J.S.: Effects of fish oil supplements in NIDDM subjects. Diabetes Care 1990; 13: 821–829PubMedCrossRefGoogle Scholar
  35. 35.
    Green D., Barreres L., Borensztain J., Kaplan P., Reddy N., Rovner R., Simon H.: A double-blind, placebo-controlled trial of fish oil concentrate (MaxEPA) in stroke patients. Stroke 1985; 16: 706709Google Scholar
  36. 36.
    Nordt y A., Lagarde M., Renaud S.: Platelets during alimentary hyperlipidaemia induced by cream and cod liver oil. Eur. J. Clin. Invest. 1984; 14Google Scholar
  37. 37.
    Dam-Mieras M.C.A., van Muller A.D., Rand M.L., Hornstra G.: Dietary lipids and macrophage procoagulant activity. Thrombosis Res. 1986; 43: 133–137CrossRefGoogle Scholar
  38. 38.
    Hansen J.B., Olsen J.O., Wilsgard L., Hsterud B.: Effects of dietary supplementation with cod liver oil on monocyte thromboplastin synthesis, coagulation and fibrinolysis. J. Int. Med. 225 Suppl. 1989; 1: 133–139Google Scholar

Copyright information

© Springer-Verlag London 1992

Authors and Affiliations

  • G. Hornstra
    • 1
  1. 1.Department of Human BiologyLimburg UniversityMaastrichtThe Netherlands

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