Abstract
Zinc deficiency induces a complex of pathological signs in all animal species studied. Among them are reduced growth rate and food intake, alopecia, skin lesions including parakeratosis and hyperkeratinization, impaired skeletal development and abnormal gait and stance. Of these visual signs, decreased food consumption is one of the first, if not the first, to be exhibited as deficiency develops. Reduced food intake in turn has dramatic effects on many other physiological and biochemical parameters so that it is difficult to distinguish the effects of reduced food intake from those specific to zinc deficiency.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alberts JC, Lang JA, Reyes PS, Briggs GM (1977) Zinc requirement of the young guinea pig. J Nutr 107: 1517–1527
Anonymous (1981) Decreased taste acuity in chronic renal patients. Nutr Rev 39: 207–210
Ashley DVM, Anderson GH (1975) Correlation between the plasma tryptophan to neutral amino acid ratio and protein intake in the self-selecting weanling rat. J Nutr 105: 1412–1421
Baer MT, King JC, Tamura T et al. (1985) Nitrogen utilization, enzyme activity, glucose intolerance and leukocyte chemotaxis in human experimental zinc depletion. Am J Clin Nutr 41: 1220–1235
Baile CA, McLaughlin CL, Della-Fera MA (1986) Role of cholecystokinin and opioid peptides in control of food intake. Physiol Rev 66: 172–234
Baker JL, Crayton JW, Nicoll RA (1971) Noradrenaline and acetylcholine responses of supraoptic neurosecretory cells. J Physiol 218: 19–32
Bettger WJ (1985) Effect of dietary protein or amino acids on the rapid change in plasma zinc concentration in rats fed zinc deficient diets. Nutr Res 5: 1153–1159
Catalanotto FA (1979) Alterations of short-term tastant-containing fluid intake in zinc deficient adult rats. J Nutr 109: 1079–1085
Chesters JK, Quarterman J (1970) Effects of zinc deficiency on food intake and feeding patterns of rats. Br J Nutr 24: 1061–1069
Chesters JK, Will M (1973) Some factors controlling food intake by zinc-deficient rats. Br J Nutr 30: 555–566
Essatara M’B, McClain CJ, Levine AS, Morley JE (1984a) Zinc deficiency and anorexia in rats: the effect of central administration of norepinephrine, muscimol and bromergocryptine. Physiol Behav 32: 479–482
Essatara M’B, Morley JE, Levine AS, Elson MK, Shafer RB, McClain CJ (1984b) The role of endogenous opiates in zinc deficiency anorexia. Physiol Behav 32: 475–478
Faraji B, Swenseid ME (1983) Growth rate, tissue zinc levels and activities of selected enzymes in rats fed a zinc-deficient diet by gastric tube. J Nutr 113: 447–455
Flanagan PR (1984) A model to produce pure zinc deficiency in rats and its use to demonstrate that dietary phytate increases the excretion of endogenous zinc. J Nutr 114: 493–502
Fraker PJ, Haas SM, Luecke RW (1977) Effect of zinc deficiency on the immune response of the young adult A/J mouse. J Nutr 107: 1889–1895
Gibson CJ, Wurtman RJ (1977) Physiological control of brain catechol synthesis by brain tyrosine concentration. Biochem Pharmacol 26: 1137–1142
Golden MHN, Golden BE (1981) Effect of zinc supplementation on the dietary intake, rate of weight gain and energy cost of tissue deposition in children recovering from severe malnutrition. Am J Clin Nutr 34: 900–908
Gordon PR, O’Dell BL (1983) Zinc deficiency and impaired platelet aggregation in guinea pigs. J Nutr 113: 239–245
Griffith PR, Alexander JC (1972) Effect of zinc deficiency on amino acid metabolism of the rat. Nutr Repts Intl 6: 9–20
Grossman SP (1962) Direct adrenergic and cholinergie stimulation of hypothalamus mechanisms. Am J Physiol 202: 872–882
Heffner TG, Hartman JA, Seiden LS (1980) Feeding increased dopamine metabolism in the rat. Science 208: 1168–1170
Henkin RI (1984) Zinc in taste function. Biol Trace Element Res 6: 263–280
Kasarkis EJ, Sparks DL, Slevin JT (1986) Changes in hypothalamic noradrenergic systems during the anorexia of zinc deficiency. Biol Trace Element Res 9: 25–35
Krebs NF, Hambidge KM, Walravens PA (1984) Increased food intake of young children receiving a zinc supplement. Am J Dis Child 138: 270–273
Leibowitz SF (1980) Control of feeding and drinking behavior and water electrolyte excretion. In: Morgane PJ, Panksepp J (eds) Behavioral studies on the hypothalamus, vol 3, part A. Marcel Dekker, New York, pp 229–437
Leibowitz SF, Brown LL (1980) Histochemical and pharmacological analysis of noradrenergic projections to the paraventricular hypothalamus in relation to feeding stimulation. Brain Res 201: 289–314
Macapinlac MP, Barney GH, Pearson WN, Darby WJ (1967) Production of zinc deficiency in the squirrel monkey. J Nutr 93: 499–510
Miller JK, Miller WJ (1962) Experimental zinc deficiency and recovery of calves. J Nutr 76: 467–474
Meyers RD (1975) Handbook of drug and chemical stimulation of the brain. Van Nostrand Reinhold, New York
O’Dell BL, Newberne PM, Savage JE (1958) Significance of dietary zinc for the growing chicken. J Nutr 65: 503–523
Ott EA, Smith WH, Stob M, Beeson WM (1964) Zinc deficiency syndrome in the young lamb. J Nutr 82: 41–50
Park JHY, Grandjean CJ, Hart MH, Erdman SH, Pour P, Vanderhoof JA (1986) Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels. Am J Physiol 251: E273 — E278
Peng Y, Benevenga NJ, Harper AE (1969) Amino acid imbalance and food intake: effect of previous diet on plasma amino acids. Am J Physiol 216: 1020–1025
Prasad AS, Miale A, Farid Z, Sandstead HH, Schulert AR, Darby WJ (1963) Biochemical studies on dwarfism, hypogonadism, and anemia. Arch Int Med 111: 407–428
Prasad AS, Rabbani P, Abbassi A, Bowersox E, Spivey Fox MR (1978) Experimental zinc deficiency in human. Ann Intern Med 89: 483–490
Quarterman J, Humphries WR (1983) The production of zinc deficiency in the guinea pig. J Comp Pathol 93: 261–270
Quarterman J, Williams RB, Humphries WR (1970) An apparatus for the regulation of the food supply to rats. Br J Nutr 24: 1049–1051
Record IR, Dreosti IE, Tulsi RS, Manuel SJ (1986) Maternal metabolism and teratogenesis in zinc-deficient rats. Teratology 33: 311–317
Reeves PG, O’Dell BL (1981a) Short-term zinc deficiency in the rat and self-selection of dietary protein level. J Nutr 111: 375–383
Reeves PG, O’Dell BL (1981b) Regulation of protein intake in zinc deficient rats. In: Howell JMcC, Gawthorne JM, White CL (eds) Trace element metabolism in animals and man. Australian Academy of Science, Canberra, pp 338–341
Reeves PG, O’Dell BL (1983) The effect of zinc deficiency on glucose metabolism in meal-fed rats. Br J Nutr 49: 441–452
Reeves PG, O’Dell BL (1984) The effect of dietary tyrosine levels on food intake in zinc deficient rats. J Nutr 114: 761–767
Stirn FE, Elvehjem CA, Hart EB (1935) The indispensability of zinc in the nutrition of the rat. J Biol Chem 109: 347–359
Tucker HF, Salmon WD (1955) Parakeratosis or zinc deficiency disease in the pig. Proc Soc Exp Biol Med 88: 613–616
Wallwork JC, Sandstead HH (1983) Effect of zinc deficiency on appetite and free amino acid concentrations in rat brain. J Nutr 113: 47–54
Wallwork JC, Fosmire GJ, Sandstead HH (1981) Effect of zinc deficiency on appetite and plasma amino acid concentrations in the rat. Br J Nutr 45: 127–136
Wallwork JC, Botnen JH, Sandstead HH (1982) Influence of dietary zinc on rat brain catecholamines. J Nutr 112: 514–519
Walravens PA, Hambidge KM (1976) Growth of infants fed a zinc supplemented formula. Am J Clin Nutr 29: 1114–1121
Williams RB, Mills CF (1970) The experimental production of zinc deficiency in the rat. Br J Nutr 24: 989–1003
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
O’Dell, B.L., Reeves, P.G. (1989). Zinc Status and Food Intake. In: Mills, C.F. (eds) Zinc in Human Biology. ILSI Human Nutrition Reviews. Springer, London. https://doi.org/10.1007/978-1-4471-3879-2_11
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3879-2_11
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3881-5
Online ISBN: 978-1-4471-3879-2
eBook Packages: Springer Book Archive