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Intraocular Tumours

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Ophthalmic Histopathology

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Abstract

Tumours arise most commonly from melanocytes in the uveal tract and malignant melanoma is the most frequently encountered tumour in the routine laboratory. The anatomical distribution frequency of uveal melanomas is 8% in iris, 12% in ciliary body and 80% in choroid.

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References

  • Abramson DH (1989) The focal treatment of retinoblastoma with emphasis on xenon arc photocoagulation. Acta Ophthalmologica (Suppl) 194: 3–63

    CAS  Google Scholar 

  • Abramson DH, Ellsworth RM, Grumbach N, Kitchen FD (1985) Retinoblastoma: survival, age at detection and comparison 1914–1958, 1958–1983. J Paediatr Ophthalmol Strabismus 22: 246–250

    CAS  Google Scholar 

  • Abramson DH, Greenfield DS, Ellsworth RM (1989) Neuron-specific enolase and retinoblastoma. Clinicopathologic correlations. Retina 9: 148–152

    Google Scholar 

  • Akiyama K, Iwasaki M, Amemiya T, Tanai M (1989) Chemotherapy for retinoblastoma. Ophthalmol Paediatr Genet 10: 111–116

    Article  CAS  Google Scholar 

  • Arnold AC, Hepler RS, Yee RW, Maggiano J, Eng LF, Foos RY (1985) Solitary retinal astrocytoma. Sury Ophthalmol 30: 173–181

    Article  CAS  Google Scholar 

  • Ashton N (1964) Primary tumours of the iris. Br J Ophthalmol 48: 650–6668

    Article  PubMed  CAS  Google Scholar 

  • Augsburger JJ, Gamel JW, Shields JA (1987) Postirradiation regression of choroidal melanoma as a risk factor for death from metastatic disease. Ophthalmology 94: 1173–1177

    PubMed  CAS  Google Scholar 

  • Baum MD, Pilkerton AR, Berler DK et al. (1979) Choroidal osteoma. Ann Ophthalmol 11: 1849–1851

    PubMed  CAS  Google Scholar 

  • Broughton WL, Zimmerman LE (1978) A clinicopathologic study of 56 cases of intraocular medulloepithelioma. Am J Ophthalmol 85: 407–418

    PubMed  CAS  Google Scholar 

  • Brown GC, Shields JA (1985) Tumours of the optic nerve head. Sury Ophthalmol 29: 239–264

    Article  CAS  Google Scholar 

  • Brown D, Boniuk M, Font RL (1990) Diffuse malignant melanoma of iris with metastases. Sury Ophthalmol 34: 357–364

    Article  CAS  Google Scholar 

  • Brown HH, Brodsky MC, Hembree K, Mrak RE (1991) Supraciliary hemangiopericytoma. Ophthalmology 98: 378–382

    PubMed  CAS  Google Scholar 

  • Brubaker RF, Pederson JE (1983) Ciliochoroidal detachment. Sury Ophthalmol 27: 281–289

    Article  CAS  Google Scholar 

  • Bunin GR, Emanuel BS, Meadows AT (1989) Frequency of 13q abnormalities among 203 patients with retinoblastoma. J Natl Cancer Inst 81: 360–364

    Article  Google Scholar 

  • Canning CR, McCartney ACE, Hungerford J (1988) Medulloepithelioma (diktyoma). Br J Ophthalmol 72: 764–767

    Article  PubMed  CAS  Google Scholar 

  • Carruthers JDA, Saunders PPR, McCormick AQ (1990) Non-pigmented congenital iris stromal cyst. Can J Ophthalmol 25: 309–310

    PubMed  CAS  Google Scholar 

  • Chapman PD, Church W, Burn J, Gunn A (1989) Congenital hypertrophy of retinal pigment epithelium: a sign of familial adenomatous polyposis. Br Med J 298: 66–70

    Article  Google Scholar 

  • Char DH, Kaleta-Michaels S, Kingston JE (1989) Metastatic retinoblastoma. Arch Ophthalmol 107: 1570–1571

    Article  PubMed  CAS  Google Scholar 

  • Char DH, Ljung N-M, Phillips T (1988) Primary intraocular lymphoma (ocular reticulum cell sarcoma) diagnosis and management. Ophthalmology 95: 625–630

    PubMed  CAS  Google Scholar 

  • Desroches G, Abrams GW, Gass JDM (1983) Reactive lymphoid hyperplasia of the uvea. Arch Ophthalmol 101: 725–728

    Article  PubMed  CAS  Google Scholar 

  • Draper GJ, Sanders BM, Kingston JE (1986) Second primary neoplasms in patients with retinoblastoma. Br J Cancer 53: 661–671

    Article  PubMed  CAS  Google Scholar 

  • Drewe RH, Lee WR (1985) Solitary astrocytic hamartoma simulating retinoblastoma. Ophthalmologica 190: 158–167

    Article  PubMed  CAS  Google Scholar 

  • Dryja TP, Albert DM, Horns D (1981) Adenocarcinoma arising from the epithelium of the ciliary body. Ophthalmology 88: 1290–1292

    PubMed  CAS  Google Scholar 

  • Dugmore WN (1972) Eleven-year follow-up of a case of leiomyosarcoma. Br J Ophthalmol 56: 366–367

    Article  PubMed  CAS  Google Scholar 

  • Dunn WJ, Lambert HM, Kincaid MC et al. (1988) Primary malignant melanoma with early vitreous seeding. Retina 8: 188–192

    Article  PubMed  CAS  Google Scholar 

  • Egan KM, Seddon JM, Glynn RJ, Gragoudas ES, Albert DM (1988) Epidemiological aspects of uveal melanoma. Sury Ophthalmol 32: 239–251

    Article  CAS  Google Scholar 

  • Ferry AP, Font RL (1974) Carcinoma metastatic to the eye and orbit. Arch Ophthalmol 92: 276–286

    Article  PubMed  CAS  Google Scholar 

  • Font RL, Spaulding AG, Zimmerman LE (1968) Diffuse malignant melanoma of the uveal tract. Trans Am Acad Ophthalmol Otolaryngol 72: 877–894

    PubMed  CAS  Google Scholar 

  • Foos RY (1985) Solitary retinal astrocytoma. Sury Ophthalmol 30: 173–181

    Article  Google Scholar 

  • Forrester JV, Lee WR, Kerr PR, Dua HS (1990) The uveal effusion syndrome and transscleral flow. Eye 4: 354–365

    Article  PubMed  Google Scholar 

  • Foulds WS, Damato BE (1989) Surgical resection of choroidal mela- nomas. In: Ryan SJ (ed) The retina. Mosby, St Louis, pp 713–720

    Google Scholar 

  • Frangieh GT, El Baba F, Traboulsi EI, Green WR (1985) Melanocytoma of the ciliary body. Sury Ophthalmol 29: 328–334

    Article  CAS  Google Scholar 

  • Freeman LN, Schachat AP, Knox DL, Michels RG, Green RW (1987) Clinical features, laboratory investigations and survival in ocular reticulum cell sarcoma. Ophthalmology 94: 1631–1638

    PubMed  CAS  Google Scholar 

  • Gass JDM, Weleber RG, Johnson DR (1987) Non-Hodgkins lymphoma causing fundus picture simulating fundus flavimaculatus. Retina 7: 209–214 (2 cases)

    Google Scholar 

  • Gass JDM, Gieser RG, Wilkinson CP, Beahm DE, Pautler SE (1990) Bilateral diffuse uveal melanocytic proliferation in patients with occult carcinoma. Arch Ophthalmol 108: 527–533

    Article  PubMed  CAS  Google Scholar 

  • Gieser SC, Hufnagel TJ, Jaros PA, MacRae D, Khodadoust AA (1988) Haemangiopericytoma of the ciliary body. Arch Ophthalmol 106: 1269–1272

    Article  PubMed  CAS  Google Scholar 

  • Gonder JR, Augsburger JJ, McCarthy EF, Shields JA (1982) Visual loss associated with choroidal naevi. Ophthalmology 89: 950–952

    PubMed  CAS  Google Scholar 

  • Gragoudas ES, Seddon JM, Egan K et al. (1987) Long-term results of proton beam irradiated melanomas. Ophthalmology 94: 349–353

    PubMed  CAS  Google Scholar 

  • Grossniklaus HE, Brown RH, Stulting RD, Blasberg RD (1990) Iris melanoma seeding through a trabeculectomy site. Arch Ophthalmol 108: 1287–1290

    Article  PubMed  CAS  Google Scholar 

  • Guyer DR, Green WR, Schachat AP, Bastacky S, Miller NR (1990) Bilateral ischaemic optic neuropathy and retinal vascular occlusions associated with lymphoma and sepsis. Ophthalmology 97: 882–888

    PubMed  CAS  Google Scholar 

  • Howard MA, Dryja TP, Walton DS, Albert DM (1989) Identification and significance of multinucleate cells in retinoblastoma. Arch Ophthalmol 107: 1025–1038

    Article  PubMed  CAS  Google Scholar 

  • Imperia PS, Lazarus HN, Lass JH (1989) Ocular complications of systemic cancer chemotherapy. Sury Ophthalmol 34: 209–230

    Article  CAS  Google Scholar 

  • Ishigooka H, Yamabe H, Kobashi Y, Nagata M (1989) Clinical and pathological status of mesectodermal leiomyoma of the ciliary body. Graefé s Arch Clin Exp Ophthalmol 227: 101–105

    Article  CAS  Google Scholar 

  • Jakobiec FA, Silbert G (1981) Are most iris “melanomas” really naevi? Arch Ophthalmol 99: 2117–2132

    Article  PubMed  CAS  Google Scholar 

  • Jensen OA (1982) Malignant melanomas of the human uvea. 25-year follow-up of cases in Denmark 1943–1952. Acta Ophthalmologica 60: 161–182

    Article  PubMed  CAS  Google Scholar 

  • Khahl MK (1983) Balloon cell malignant melanoma of the choroid. Br J Ophthalmol 67: 579–584

    Article  Google Scholar 

  • Kindy-Degnan NA, Char DH, Castro JR et al. (1989) Effect of various doses of radiation on regression, visual acuity, complications and survival. Am J Ophthalmol 107: 114–120

    PubMed  CAS  Google Scholar 

  • Kingston JE, Plowman PN, Hungerford JL (1985) Ectopic intracranial retinoblastoma in childhood. Br J Ophthalmol 69: 742–748

    Article  PubMed  CAS  Google Scholar 

  • Kivela T, Tarkkanen A (1988) Recurrent medullo-epithelioma of the ciliary body: immunohistochemical characteristics. Ophthalmology 95: 1565–1575

    PubMed  CAS  Google Scholar 

  • Kivela T, Kauniskangas L, Miettinen P, Tarkkanen A (1989) Clioneuroma associated with colobomatous dysplasia of the anterior uvea and retina. A case simulating medulloepithelioma. Ophthalmology 96: 1799–1808

    Google Scholar 

  • Latina M, Flotte T, Crean E, Sherwood E, Granstein RD (1988) Immunohistochemical staining of the human anterior segment. Evidence that resident cells play a role in immunologic response. Arch Ophthalmol 106: 95–99

    Google Scholar 

  • Lee WR (1987) Pseudomelanomas after conservative management of uveal melanoma. Eye 1: 668–675

    Article  PubMed  Google Scholar 

  • Lee WR, Jay JL (1985) A complicated case of ciliary body melanoma and glaucoma. Int Ophthalmol 7: 175–181

    Article  PubMed  CAS  Google Scholar 

  • Li Z-Y, Tso MOM, Sugar J (1987) Leiomyoepithelioma of the iris pigment epithelium. Arch Ophthalmol 105: 819–824

    Article  PubMed  CAS  Google Scholar 

  • Liang JC, Ausburger JJ, Shields JA (1985) Diffuse infiltrating retino-blastoma associated with persistent primary vitreous. J Paediatr Ophthalmol Strabismus 22: 31–33

    CAS  Google Scholar 

  • Lieb WE, Shields JA, Eagle RC, Kwa D, Shields CL (1990) Cystic adenoma of the pigmented ciliary epithelium: clinical, pathologic and immunohistopathologic findings. Ophthalmology 97: 1489–1493

    PubMed  CAS  Google Scholar 

  • Ljung B-M, Char D, Miller TR, Deschenes J (1988) Intraocular lymphoma: cytologic diagnosis and the role of immunologic markers. Acta Cytol 32: 840–847

    PubMed  CAS  Google Scholar 

  • Magram I, Abrahamson DH, Ellsworth RM (1989) Optic nerve involvement in retinoblastoma. Ophthalmology 96: 217–222

    Google Scholar 

  • Manschot WA, van Peperzeel HA (1980) Choroidal melanoma. Enucleation or observation? A new approach. Arch Ophthalmol 98: 71–77

    Article  PubMed  CAS  Google Scholar 

  • Manschot WA, van Striik R (1987) Is irradiation a justifiable treatment of choroidal melanoma? Analysis of published results. Br J Ophthalmol 71: 348–352

    Article  PubMed  CAS  Google Scholar 

  • Marcus DM, Craft JL, Albert DM (1990a) Histopathologic verification of Verhoeff’s 1918 irradiation cure of retinoblastoma. Ophthalmology 97: 221–224

    PubMed  CAS  Google Scholar 

  • Marcus DM, Minkovitz JB, Wardwell SD, Albert DM (1990b) The value of nucleolar organizer regions in uveal melanoma. Am J Ophthalmol 110: 527–534

    PubMed  CAS  Google Scholar 

  • Margo C, Hidayat A, Kopelman J, Zimmerman LE (1983) Retinocytoma. Arch Ophthalmol 101: 1519–1531

    Article  CAS  Google Scholar 

  • Margo CE, Pavan PR, Gendelman D, Gragoudas E (1987) Bilateral melanocytic uveal tumours associated with systemic non-ocular malignancy. Malignant melanomas or benign paraneoplastic syndrome. Retina 7: 137–141

    Google Scholar 

  • Martow J, Polomeno RC, Lewandowski R et al. (1990) The importance of congenital hypertrophy of the retinal pigment epithelium in familial adenomatous polyposis. Can J Ophthalmol 25: 290–292

    PubMed  CAS  Google Scholar 

  • McLean IW, Foster WD, Zimmerman LE (1982) Uveal melanoma: Location, size, cell type and enucleation as risk factors in metastasis. Hum Path 13: 123–132

    Google Scholar 

  • McLean IW, Foster WD, Zimmerman LE, Gamel JW (1983) Modification of Callender’s classification of uveal melanoma at the Armed Forces Institute of Pathology. Am J Ophthalmol 96: 502–509

    PubMed  CAS  Google Scholar 

  • McMenamin PG, Lee WR (1986) Ultrastructural pathology of melanomalytic glaucoma. Br J Ophthalmol 70: 895–906

    Article  PubMed  CAS  Google Scholar 

  • Messmer EP, Font RL, Kirkpatrick JB, Hopping W (1985) Immunohistochemical demonstration of neuronal and astrocytic differentiation in retinoblastoma. Ophthalmology 92: 167–173

    PubMed  CAS  Google Scholar 

  • Messmer EP, Heinrich T, Hopping W et al. (1991) Risk factors for metastases in patients with retinoblastoma. Ophthalmology 98: 136–141

    PubMed  CAS  Google Scholar 

  • Munden PM, Sobol WM, Weingeist TA (1991) Ocular findings in Turcot syndrome (glioma-polyposis). Ophthalmology 98: 111–114

    PubMed  CAS  Google Scholar 

  • Naumann GOH, Font RL, Zimmerman LE (1972) Electron microscopic verification of primary rhabdomyosarcoma of the iris. Am J Ophthalmol 74: 110–117

    Google Scholar 

  • Naumann GOH, Ruprecht KW (1972) Xanthome der Iris. Ophthalmolgica 164: 292–305

    Google Scholar 

  • Nelson CC, Hertzberg BS, Klintworth GK (1983) A histopathologic study of 716 unselected eyes in patients with cancer at the time of death. Am J Ophthalmol 95: 788–793

    Article  PubMed  CAS  Google Scholar 

  • Ohnishi Y, Yamana Y, Minei M (1986) Photoradiation therapy using argon laser and a haematoporphyrin derivatives for retino-blastoma–a preliminary report. Jpn J Ophthalmol 30: 409–419

    PubMed  CAS  Google Scholar 

  • Pesin SR, Shields JA (1989) Seven cases of trilateral retinoblastoma. Am J Ophthalmol 107: 121–126

    PubMed  CAS  Google Scholar 

  • Reidy JJ, Apple DJ, Steinmetz RL et al. (1985) Melanocytoma: nomenclature, pathogenesis, natural history and treatment. Sury Ophthalmol 29: 319–325

    Article  CAS  Google Scholar 

  • Riddle PJ, Font RL, Zimmerman LE (1982) Carcinoid tumours of the eye and orbit. Hum Pathol 13: 459–469

    Article  PubMed  CAS  Google Scholar 

  • Roarty JD, McLean IW, Zimmerman LE (1988) Incidence of second neoplasms in patients with bilateral retinoblastoma. Ophthalmology 95: 1583–1587

    PubMed  CAS  Google Scholar 

  • Rodrigues MM, Bardenstein DS, Donoso LA, Rajagopalan S, Brownstein S (1987a) An immunohistochemical study of trilateral retinoblastoma. Am J Ophthalmol 103: 776–781

    PubMed  CAS  Google Scholar 

  • Rodrigues MM, Wiggert B, Shields et al. (1987b) Retinoblastoma. Immunohistochemistry and cell differentiation. Ophthalmology 94: 378–387

    Google Scholar 

  • Rodrigues M, Hidayat A, Karesh J (1988) Pleomorphic adenocarcinoma of ciliary epithelium simulating an epibulbar tumour. Am J Ophthalmol 106: 595–600

    Article  PubMed  CAS  Google Scholar 

  • Romanji J, Graner A, Prasad J et al. (1987) Characterisation of ocular melanoma with cutaneous melanoma antibodies. Br J Ophthalmol 71: 647–650

    Article  Google Scholar 

  • Rosenbaum PS, Boniuk, Font RL (1988) Diffuse melanoma in a 5-year-old child. Am J Ophthalmol 106: 601–606

    Article  PubMed  CAS  Google Scholar 

  • Schanzer MC, Font RL, O’Malley RE (1991) Primary ocular malignant lymphoma associated with the acquired immune deficiency syndrome. Ophthalmology 98: 88–91

    PubMed  CAS  Google Scholar 

  • Sevel D, Tobias B (1972) The value of fluorescein angiography with leiomyoma of the iris. Am J Ophthalmol 74: 475–478

    PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, Augsburger JJ (1988) Choroidal osteoma. Sury Ophthalmol 33: 17–27

    Article  CAS  Google Scholar 

  • Shields CL, Shields JA, Karlsson U, Menduke H, Brady LW (1990a) Enucleation after plaque radiotherapy for posterior uveal melanoma: histopathologic findings. Ophthalmology 97: 1665–1670

    PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, Varenhorst MP (1991a) Transcleral leiomyoma. Ophthalmology 98: 84–87

    PubMed  CAS  Google Scholar 

  • Shields CL, Shields JA, Shah P (1991b) Retinoblastoma in older children. Ophthalmology 98: 395–399

    PubMed  CAS  Google Scholar 

  • Shields JA, Shields CL, Parsons H, Giplin ME (1990b) The role of photocoagulation in the management of retinoblastoma. Arch Ophthalmol 108: 205–208

    Article  PubMed  CAS  Google Scholar 

  • Shields JA, Shields CL, Shah P, Sivilangham V (1991c) Partial lamellar sclerouvectomy for ciliary body and choroidal tumours. Ophthalmology 98: 971–983

    PubMed  CAS  Google Scholar 

  • Shields MB (1979) Progressive essential iris atrophy, Chandler’s syndrome and the iris naevus (Cogan Reese) syndrome: a spectrum of disease. Sury Ophthalmol 24: 3–20

    Article  CAS  Google Scholar 

  • Shuangshoti S, Chaiwun B, Kasantikul V (1989) A study of 39 retinoblastomas with particular reference to morphology, cellular differentiation and tumour origin. Histopathology 15: 113–124

    Article  PubMed  CAS  Google Scholar 

  • Smith PA, Damato BE, Ko M-K, Lyness RW (1987) Anterior uveal neurilemmoma–a rare neoplasm simulating malignant melanoma. Br J Ophthalmol 71: 34–40

    Article  PubMed  CAS  Google Scholar 

  • Sneed SR, Vine AK, Arbor A (1991) Spontaneous collapse of a primary iris cyst associated with an iris nevus. Arch Ophthalmol 109: 21–22

    Article  PubMed  CAS  Google Scholar 

  • Tagaki UY, Matsuya N (1985) Mesoectodermal leiomyoma of the ciliary body: an ultrastructural study. Arch Ophthalmol 103: 1711

    Article  Google Scholar 

  • Tamboli A, Podger MJ, Horm JW (1990) The incidence of retino-blastoma in the United States: 1974 through 1985. Arch Ophthalmol 108: 128–132

    Article  PubMed  CAS  Google Scholar 

  • Tso MOM (1980) Clues to the cells of origin in retinoblastoma. In: Albert DM, Weichselbaum RR (eds) Advances regarding the pathogenesis and treatment of ocular tumours. Little Brown, Boston, pp 191–210

    Google Scholar 

  • Wakakura M, Lee WR (1990) Ultrastructural pleomorphism in medulloepithelioma of the ciliary body: a comparative study of tumour cells and fetal ciliary epithelium. Jpn J Ophthalmol 34: 364–380

    PubMed  CAS  Google Scholar 

  • White V, Stephenson K, Garner A, Hungerford J (1989) Mesectodermal leiomyoma of the ciliary body: case report. Br J Ophthalmol 73: 12–18

    Article  PubMed  CAS  Google Scholar 

  • Williams R, Taylor D (1985) Tuberous sclerosis. Sury Ophthalmol 30: 143–154

    Article  CAS  Google Scholar 

  • Wilson ME, McClatchey SK, Zimmerman LE (1990) Rhabdo- myosarcoma of the ciliary body. Ophthalmology 97: 1484–1488

    PubMed  CAS  Google Scholar 

  • Winther JB (1990) The effect of photodynamic therapy on a retinoblastoma-like tumour. Acta Ophthalmologica 68: 1–37

    Google Scholar 

  • Wirz K, Lee WR, Coaker T (1982) Progressive changes in congenital hypertrophy of the retinal pigment epithelium. Graefé s Arch Klin Exp Ophthalmol 219: 214–221

    Article  CAS  Google Scholar 

  • Yu DY, Cohen SB, Peyman G, Tso MOM (1990) Mesectodermal leiomyoma of the ciliary body: new evidence for neural crest origin. J Paediatr Ophthalmol Strabismus 27: 317–321

    CAS  Google Scholar 

  • Zimmerman LE, McLean IW, Foster WD (1978) Does enucleation of the eye containing a malignant melanoma prevent or accelerate the dissemination of tumour cells? Br J Ophthalmol 62: 420–425

    Article  PubMed  CAS  Google Scholar 

  • Zimmerman LE, McLean IW, Foster WD (1980) The Manschot-van Peperzeel concept of the growth and metastasis of uveal melanomas. Doc Ophthalmol 50: 101–121

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Glasgow, Western Infirmary, G11 6NT, Glasgow, UK

    W. R. Lee MD, FRCPath, FCOphth, FRSE (Titular Professor of Ophthalmic Pathology)

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  1. W. R. Lee MD, FRCPath, FCOphth, FRSE
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© 1993 Springer-Verlag London

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Lee, W.R. (1993). Intraocular Tumours. In: Ophthalmic Histopathology. Springer, London. https://doi.org/10.1007/978-1-4471-3843-3_5

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  • DOI: https://doi.org/10.1007/978-1-4471-3843-3_5

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