Biochemical Markers and Bone
It is well established that a low bone mass is associated with an increased risk of osteoporotic fractures. Peak bone mass and bone loss with aging are the major determinants of osteoporosis . It has not been clearly established at what age the negative bone balance starts. An accelerated loss of bone is seen immediately after the menopause, continuing for 2–8 years [2,3]. Serum and urinary levels of biochemical markers of bone turnover are increased during that period and return to premenopausal levels during hormone replacement therapy (HRT). This has been shown in groups of patients treated with HRT [4,5]. Significant suppression of biochemical markers has also been demonstrated in groups of patients treated with other antiresorptive agents such as bisphosphonates [6,7] or raloxifene . The clinical usefulness of monitoring the bone markers in an individual patient is, however, less evident.
KeywordsPlacebo Estrogen Osteoporosis Creatinine Proline
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