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Management of Fractures in Severely Osteoporotic Bone pp 13–32Cite as

Pathogenesis of Osteoporosis

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Abstract

Osteoporosis is defined pathologically as “a systemic disease causing an absolute decrease in the amount of bone and microstructural changes, leading to skeletal fragility and consequent fractures after minimal trauma (low energy fractures)”. The classical osteoporotic fractures affect primarily bones with large amounts of cancellous bone, i.e. spine, hip and forearm. Cancellous bone is metabolically much more active than cortical bone; therefore this phenomenon suggests that perturbations in bone remodelling play a pivotal role in the development of osteoporosis. In this chapter we will re-examine the different factors that may lead to perturbations of bone remodelling.

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Authors
  1. E. F. Eriksen
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  2. H. Glerup
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Editors and Affiliations

  1. Department of Medicine, Surgery and Orthopaedics, Malmö University Hospital, S-205 02, Malmö, Sweden

    Karl Obrant (Professor of Orthopaedics, Head) (Professor of Orthopaedics, Head)

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© 2000 Springer-Verlag London

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Eriksen, E.F., Glerup, H. (2000). Pathogenesis of Osteoporosis. In: Obrant, K. (eds) Management of Fractures in Severely Osteoporotic Bone. Springer, London. https://doi.org/10.1007/978-1-4471-3825-9_2

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  • DOI: https://doi.org/10.1007/978-1-4471-3825-9_2

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  • Print ISBN: 978-1-84996-855-3

  • Online ISBN: 978-1-4471-3825-9

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