An Introduction to the Endopeptidases
A very large number of proteolytic enzymes exist in the human body, and it is no easy matter to work out how they are involved in specific physiological and pathological processes. A concept that has proved helpful in this is that of splitting the enzymes into groups on the basis of (a) the type of reaction that they catalyse and (b) the chemical mechanism of catalysis that they use.
KeywordsCysteine Serine Trypsin Pseudomonas Smoke
Unable to display preview. Download preview PDF.
- 2.Barrett A.J.: Introduction: the classification of proteinases. In: Evered D., Whelan J., (Eds.): Protein Degradation in Health and Disease (Ciba Foundation Symposium 75), Amsterdam, Excerpta Medica, 1980: 1–13Google Scholar
- 3.Barrett A.J.: A trap for proteinases. Current Contents 1989; 32 (2): 14Google Scholar
- 13.Barrett A.J.: The cystatins: a new class of peptidase inhibitors. Trends Biochem. Sci. 1987; 12: 193–196Google Scholar
- 15.Abrahamson M., Mason R.W., Hansson H., Grubb A., Buttle D.J. Ohlsson K.: Leukocyte elastase can inactivate the human cysteine proteinase inhibitor, cystatin C, by cleavage of a single N-terminal bond. Biochem. J. 1990; 273: 621–626Google Scholar