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Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema

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Biochemistry of Pulmonary Emphysema

Part of the book series: Current Topics in Rehabilitation ((CURRENT REHAB))

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Abstract

Emphysema is a process characterized by enlargement of the respiratory airspaces of the lungs with destruction of the walls between airspaces. In persons with adequate protective levels of α-1 protease inhibitor (API) the most important risk factors for the development of emphysema are the smoking history, age and the level of ventilatory function as measured by the forced expiratory volume for 1 sec (FEV1).1–4 About 15% of long term smokers are at risk of developing chronic obstructive pulmonary disease (COPD).3

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Authors and Affiliations

  1. The Boston Veterans Administration Medical Center; Pulmonary Center and Biochemistry Department, Boston University School of Medicine; Boston University and Tufts University Schools of Medicine, Boston, Massachusetts, USA

    G. L. Snider, P. J. Stone & E. C. Lucey

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  1. G. L. Snider
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  2. P. J. Stone
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  3. E. C. Lucey
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Editors and Affiliations

  1. Institute of Phthisiology and Respiratory Diseases, IRCCS San Matteo, University of Pavia, Italy

    C. Grassi  & M. Luisetti  & 

  2. Department of Biochemistry, University of Georgia, Athens, GA, USA

    J. Travis

  3. Postgraduate School of Respiratory Diseases, University of Pavia, Italy

    L. Casali

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© 1992 Springer-Verlag London

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Snider, G.L., Stone, P.J., Lucey, E.C. (1992). Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema. In: Grassi, C., Travis, J., Casali, L., Luisetti, M. (eds) Biochemistry of Pulmonary Emphysema. Current Topics in Rehabilitation. Springer, London. https://doi.org/10.1007/978-1-4471-3771-9_11

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  • DOI: https://doi.org/10.1007/978-1-4471-3771-9_11

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3773-3

  • Online ISBN: 978-1-4471-3771-9

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