Clinical Features of Hypermobility: Locomotor System and Extra-articular

  • Peter Beighton
  • Rodney Grahame
  • Howard Bird

Abstract

The majority of people with lax ligaments and loose joints probably suffer no articular problems. For example, symptoms were no more prevalent amongst a group of 31 healthy hypermobile blood donors (average age 28 years) than in age- and sex-matched controls (Jessee et al. 1980). For most hypermobile subjects the impression is that it is a positive attribute, which enables enhanced participation in a wide variety of physical activities (see Chapter 8). However, not all are so fortunate, and some do experience locomotor and other problems as a direct effect of their laxity. Joint hypermobility is a feature common to most of the heritable disorders of connective tissue (HDCT), which include the Ehlers-Danlos and Marfan syndromes (EDS; MFS) and osteogenesis imperfecta (01) (see Chapter 9). It is seen in its grossest form in the EDS. Generally speaking the likelihood of developing symptoms, notably arthralgia and joint instability, is directly proportional to the degree of hypermobility, although exceptions to this rule occur. When symptoms occur in seemingly otherwise healthy individuals the term hypermobility syndrome (HMS) is applied (Kirk et al. 1967). In recent years, however, its usage has been increasingly replaced by the preferred term “benign joint hypermobility syndrome” (BJHS) because of the favourable prognosis, at least, as far as threat to life is concerned. Some authorities refer to BJHS as the familial articular hypermobilty; others to Ehlers-Danlos Syndrome Type III (EDS III), although this remains a contentious issue.

Keywords

Arthritis Osteoarthritis Endometriosis Hyperparathyroidism Spondylitis 

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Copyright information

© Springer-Verlag London 1999

Authors and Affiliations

  • Peter Beighton
    • 1
  • Rodney Grahame
    • 2
  • Howard Bird
    • 3
  1. 1.Department of Human GeneticsUniversity of Cape Town Medical SchoolCape TownSouth Africa
  2. 2.Hypermobility ClinicUCL HospitalsLondonUK
  3. 3.Clinical Pharmacology UnitUniversity of Leeds, Chapel Allerton HospitalLeeds, West YorkshireUK

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