Acid-Base Balance

  • D. C. Flenley


An acid is defined as a proton donor which in aqueous solution undergoes an ionic dissociation to form free protons, the chemical properties of these in solution being a function of the hydrogen ion activity [H+], which is related to the concentration of hydrogen ions by the activity coefficient; this can only be calculated theoretically for solutions of very low concentrations.


Metabolic Acidosis Lactic Acidosis Renal Tubular Acidosis Metabolic Alkalosis Respiratory Alkalosis 
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  1. 1.
    Brezis M, Rowe M, Shalev O (1979) Reversal of lactic acidosis associated with heart failure by nitroprusside administration. Br Med J 1: 1399–1400PubMedCrossRefGoogle Scholar
  2. 2.
    Bunker JP (1965) The great trans-Atlantic acid hase debate. Anesthesiology 26: 591–594PubMedGoogle Scholar
  3. 3.
    Campbell EJM (1965) Respiratory failure. Br Med J 1: 1451–1460PubMedCrossRefGoogle Scholar
  4. 4.
    Cohen RB, Wood HF (1976) The clinical chemical and biochemical basis of lactic acidosis. Blackwell Scientific Publications, OxfordGoogle Scholar
  5. 5.
    Derenne JPH, Macklem PT, Roussos CH (1978) The respiratory muscles: Mechanics, control and pathophysiology. Am Rev Respir Dis, 118:119–133, 373–390, 581–601Google Scholar
  6. 6.
    Flenley DC (1970) Respiratory failure. Scott Med J 15: 61–72PubMedGoogle Scholar
  7. 7.
    Flenley DC (1971) Another non-logarithmic acid-base diagram? Lancet 1: 961–965PubMedCrossRefGoogle Scholar
  8. 8.
    Flenley DC (1978) Interpretation of blood-gas and acid-base data. Br J Hosp Med 20: 384–394PubMedGoogle Scholar
  9. 9.
    Fulop M (1979) Serum potassium in lactic acidosis and ketoacidosis. N Engl J Med 300: 1087–1089PubMedCrossRefGoogle Scholar
  10. 10.
    Gabow PA, Anderson RJ, Potts DE, Schrier RW (1978) Acid-base disturbances in the salicylate-intoxicated adult. Arch Intern Med 138: 1481–1484PubMedCrossRefGoogle Scholar
  11. 11.
    Guilleminault C, Dement WC (eds) (1978) Sleep apnea syndromes. Alan R Liss, New York (Kroc foundation series, vol 11 )Google Scholar
  12. 12.
    Hems DA (1975) Biochemical aspects of renal ammonia formation in metabolic acidosis. Enzyme 20: 359–380PubMedGoogle Scholar
  13. 13.
    Henderson LJ (1908) The theory of neutrality regulation in the animal organism. Am J Physiol 21: 427–448Google Scholar
  14. 14.
    Levinsky NG, Robert NJ (1979) Severe metabolic acidosis in a young man. N Engl J Med 301: 650–657CrossRefGoogle Scholar
  15. 15.
    Miyamoto T, Mizuno K, Furuya K (1970) Arterial blood gases in bronchial asthma. J Allergy Clin Immunol 56: 248–254Google Scholar
  16. 16.
    Misbin RI (1977) Phenformin-associated lactic acidosis: Pathogenesis and ttreatment. Ann Intern Med 87: 59 1595Google Scholar
  17. 17.
    Moser KM, Luchsinger PC, Adamson JS, McMahon SM, Schleuter DP, Spivack M, Weg JG (1973) Respiratory stimulation with intravenous doxapram in respiratory failure. N Engl J Med 288: 427–431PubMedCrossRefGoogle Scholar
  18. 18.
    Murray JF (ed) (1977) Mechanisms of acute respiratory failure. Am Rev Respir Dis 115: 1071–1078Google Scholar
  19. 19.
    McFadden ER, Lyons HA (1968) Arterial blood-gas tension in asthma. N Engl J Med 278: 1027–1032PubMedCrossRefGoogle Scholar
  20. 20.
    Rees HA, Millar JS, Donald KW (1968) A study of the clinical course and arterial blood gas tensions in patients in status asthmaticus. Q J Med 37: 541–561PubMedGoogle Scholar
  21. 21.
    Sabatini S, Arruda JAL, Kurtzman NA (1978) Disorders of acid base balance. Med Clin North Am 62 6: 1223–1255PubMedGoogle Scholar
  22. 22.
    Schwartz WB, Cohen JJ (1978) The nature of the renal response to chronic disorders of acid-base equilibrium. Am J Med 64: 417–428PubMedCrossRefGoogle Scholar
  23. 23.
    Siggaard-Andersen 0 (1964) The acid-base status of the blood, 2nd edn. Munksgaard, Copenhagen, p 26Google Scholar
  24. 24.
    Springer RR, Stevens PM (1979) The influence of PEEP on survival of patients in respiratory failure. Am J Med 66: 196–200PubMedCrossRefGoogle Scholar
  25. 25.
    Tai E, Read J (1967) Blood-gas tensions in bronchial asthma. Lancet 1: 644–646PubMedCrossRefGoogle Scholar
  26. 26.
    Tuller MA, Mehdi F (1971) Compensatory hypoventilation and hypercapnia in primary metabolic alkalosis. Am J Med 50: 281–290PubMedCrossRefGoogle Scholar
  27. 27.
    Vaziri ND, Ness R, Wellikson L, Barton C, Greep N (1979) Bicarbonate-buffered peritoneal dialysis. An effective adjunct in the treatment of lactic acidosis. Am J Med 67: 392–396Google Scholar
  28. 28.
    Warren PM, Flenley DC, Millar JS, Avery A (1980) Respiratory failure revisited: Acute exacerbations of chronic bronchitis between 1961–68 and 1970–76. Lancet 1: 467–471PubMedCrossRefGoogle Scholar
  29. 29.
    Wasserman K, Whipp BJ, Koyal SN, Beaver WL (1973) Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 35: 236–243PubMedGoogle Scholar
  30. 30.
    Worthley LIG (1977) The rational use of i.v. hydrochloric acid in the treatment of metabolic alkalosis. Br J Anaesth 49: 811–817PubMedCrossRefGoogle Scholar
  31. 31.
    Wrong O, Davies HEF (1959) The excretion of acid in renal disease. Q J Med 28: 259–313PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1983

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  • D. C. Flenley

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