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Immobilised Macromolecules: Application Potentials pp 195–207Cite as

Crystalline Bacterial Cell Surface Layers (S-Layers) as Combined Carrier/Adjuvants for Conjugate Vaccines

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Part of the book series: Springer Series in Applied Biology ((SSAPPL.BIOLOGY))

Abstract

The development of vaccines to prevent human and animal diseases has been a challenging task for generations of physicians, microbiologists and biochemists. Jenner’s fundamental publication on inoculation of susceptible people with cowpox virus was the first documented evidence for the efficacy of vaccination (Jenner 1798). Since then, a number of vaccines against a variety of viral and bacterial infections have been used in man and animals. Other vaccines have been developed to protect against parasitic infections. More recently, experimental immunotherapies against cancers have been developed which utilise conjugate vaccine technology (for review see Bittle and Murphy 1989). Although only a few diseases have been totally eliminated through vaccination, the availability of vaccines has led to dramatic reductions in morbidity and mortality. However, there are still many infectious diseases against which vaccines need to be developed (for reviews see Bell and Torrigiani 1987; Mizrahi 1990). Moreover, problems remain regarding the efficacy of some currently available vaccines in the general population. The development of new carrier materials, capable of enhancing immunogenicity and long term immunological memory, is seen as an important contribution toward solving the remaining problems in vaccination.

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Authors
  1. A. J. Malcolm
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  2. P. Messner
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  3. U. B. Sleytr
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  4. R. H. Smith
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  5. F. M. Unger
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Editor information

Editors and Affiliations

  1. Zentrum für Ultrastrukturforschung, Universität für Bodenkultur, A-1180, Vienna, Austria

    U. B. Sleytr , P. Messner , D. Pum  & M. Sára , ,  & 

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© 1993 Springer-Verlag London

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Malcolm, A.J., Messner, P., Sleytr, U.B., Smith, R.H., Unger, F.M. (1993). Crystalline Bacterial Cell Surface Layers (S-Layers) as Combined Carrier/Adjuvants for Conjugate Vaccines. In: Sleytr, U.B., Messner, P., Pum, D., Sára, M. (eds) Immobilised Macromolecules: Application Potentials. Springer Series in Applied Biology. Springer, London. https://doi.org/10.1007/978-1-4471-3479-4_13

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  • DOI: https://doi.org/10.1007/978-1-4471-3479-4_13

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3481-7

  • Online ISBN: 978-1-4471-3479-4

  • eBook Packages: Springer Book Archive

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