Summary
Two genes from Staphylococcus aureus encoding fibronectin binding proteins have been cloned. One of these, fnbA, is completely sequenced while the second gene, fnbB, so far is only partially cloned. FnBPA, consisting of 1018 amino acids, can be divided into different domains. One of these domains is a 38 amino acid long unit, repeated three times and partly a fourth time, responsible for the binding of fibronectin. The cloned and sequenced part of the fnbB gene does not encode the 38 amino acid repeats but still the expressed peptide binds fibronectin, which shows that Staphylococcus aureus has more than one mechanism for fibronectin binding.
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Lindberg, M., Jönsson, K., Müller, HP., Signäs, C., Höök, M. (1990). Fibronectin Binding Proteins from Staphylococcus aureus . In: Wadström, T., Eliasson, I., Holder, I., Ljungh, Å. (eds) Pathogenesis of Wound and Biomaterial-Associated Infections. Springer, London. https://doi.org/10.1007/978-1-4471-3454-1_6
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DOI: https://doi.org/10.1007/978-1-4471-3454-1_6
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