Abstract
In 1963 it was shown that nalidixic acid inhibited DNA synthesis, but not until 1976 was the intracellular “target” protein identified as DNA gyrase. Until that time DNA gyrase had not even been identified as a cellular component, but subsequent studies have shown this enzyme to be an essential component of the bacterial cell and related type II DNA topoisomerases to be essential for all cellular systems.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Baird JP, Bourguignon GJ and Sternglanz R (1972) Effects of Nalidixic acid on the growth of DNA bacteriophages. J Virol. 9:17–21
Barrett JF, Gootz TD, McGuirck PR, Farrell C, Sokolowski S and Frescura M (1987) Use of in vitro topoisomerase II assays in studying nalidixic acid derivatives. XXV ICAAC (New York)
Crumplin GC and Smith JT (1976) Nalidixic acid and bacterial chromosome replication. Nature 260:643–645
Dermody JJ, Bourguignon GJ, Foglesong PD and Sternglanz R (1974) Nalidixic acid-sensitive and resistant modes of DNA replication in Escherichia coli. Biochem Biophys Res Comm 61:1340–1347
Drlica K, Engle EE and Manes SH (1980) DNA gyrase on the bacterial chromosome: Possibility of two levels of action. Proc Natl Acad Sci 77:6879–6883
Eamshaw WC and Heck MMS (1985) Localization of topoisomerase II in mitotic chromosomes. J Cell Biology 100:1716–1725
Earnshaw WC, Halligan B, Cooke CA, Heck MMS and Liu LP (1985) Topoisomerase II is a structural component of mitotic chromosome scaffolds. J Cell Biology 100:1706–1715.
Fisher LM, Barot HA, Cullen ME and Hulton CS (1986) DNA breakage by E. coli DNA gyrase in vitro and in vivo. Biochem Soc Transact 14: 493–496
Franco RJ and Drlica K (1988) DNA gyrase on the bacterial chromosome. Oxolinic acid-induced DNA cleavage in the dnaA-gyrB region. J Molec Biol 201:229–233
Gasser SM and Laemmli UK (1986) Cohabitation of scaffold binding regions with upstream/enhancer elements of the developmentally regulated genes of D. melanogaster. Cell 46:521–530
Gudas U and Pardee AB (1975) Model for the regulation of DNA repair functions.Proc Natl Acad Sci 72:2330–2334
Heller RA, Fairman R, Philip M and Brutlag DL (1986) Cloning and characterization of the Drosophila DNA topoisomerase IE gene and its expression during development Cold Spring Harbor Symposium (Sept)
Hill WE and Fangman WL (1973) Single-strand breaks in deoxyribonucleic acid and viability loss during deoxyribonucleic acid synthesis in Escherichia coli. J Bacteriol 116:1329–1335
Huang WM, Nicholson G, Fang M and Gibson A (1986) Structure and function of T4 DNA topoisomerase subunits. Cold Spring Harbor Symposium (Sept)
Kreuzer KN and Cozzarelli NR (1979) Escherichia coli mutants thermosensitive for DNA gyrase subunit A: Effect on DNA replication, transcription and bacteriophage growth. J Bacteriol 140:424–435
Lother H, Lurz R and Orr E (1984) DNA binding and antigenic specificities of DNA gyrase. Nucleic Acids Research 12:901–913
Lynn R, Giaever G, Swanberg SL and Wang JC (1986) Tandem regions of yeast DNA topoisomerase II share homology with different subunits of bacterial gyrase. Science 233:647–649
Moriya S, Ogasawara N and Yoshikawa H (1985) Structure and function of the region of the replication origin of the Bacillus subtilis chromosome: HI Nucleotide sequence of some 10 000 base pairs in the origin region. Nucleic Acids Res 13:2251–2265
Smith CL (1983) recF-dependent induction of recA synthesis by coumermycin, a specific inhibitor of the B subunit of DNA gyrase. Proc Natl Acad Sci 80:2510–2513
Steck TR and Drlica K (1985) Involvement of DNA gyrase in bacteriophage T7 growth. J Virol 53:296–298
Uemura T and Yanagida M (1986) Functional domains in DNA topoisomerase II. Cold Spring Harbor Symposium (Sept)
Worcel A and Burgi E (1972) On the structure of the folded chromosome of Escherichia coli. J Molec Biol 71:127–147
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag London Limited
About this chapter
Cite this chapter
Crumplin, G.C. (1990). Molecular Effects of 4-Quinolones upon DNA Gyrase: DNA Systems. In: Crumplin, G.C. (eds) The 4-Quinolones: Anti Bacterial Agents in Vitro. Springer Series in Applied Biology. Springer, London. https://doi.org/10.1007/978-1-4471-3449-7_5
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3449-7_5
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3451-0
Online ISBN: 978-1-4471-3449-7
eBook Packages: Springer Book Archive