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In Vitro Genotoxicity Assessment and the Effects of 4-Quinolones upon Human Cells

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The 4-Quinolones: Anti Bacterial Agents in Vitro

Part of the book series: Springer Series in Applied Biology ((SSAPPL.BIOLOGY))

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Abstract

The last five years have seen the emergence of several new derivatives of Nalidixic acid which display great antibacterial potency and broad-spectrum antibacterial activity. Recent national and international meetings have clearly demonstrated that this group of compounds, known collectively as the 4-quinolones, are at present the most intensively studied group of antibacterial chemotherapeutic agents. Evidence is rapidly accumulating which suggests that these agents have the potential to become amongst the most exciting and challenging clinical agents to enter clinical use since the advent of the ß-lactams. The 4-quinolones act through a uniquely complex mechanism of action upon DNA topoisomerases. These enzymes control the spatial geometry of the cellular DNA and in molecular biology they are providing new insights into how cells perform the routine mechanical tasks of replicating DNA and transcribing the genetic information. It is becoming increasingly evident that the DNA topoisomerases are fundamentally important in sustaining the normal life-processes of all cellular organisms from the simple bacterium through to Homo sapiens.

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  1. G. C. Crumplin
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  1. Department of Biology, University of York, York, YO1 5DD, UK

    Geoff C. Crumplin

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Crumplin, G.C. (1990). In Vitro Genotoxicity Assessment and the Effects of 4-Quinolones upon Human Cells. In: Crumplin, G.C. (eds) The 4-Quinolones: Anti Bacterial Agents in Vitro. Springer Series in Applied Biology. Springer, London. https://doi.org/10.1007/978-1-4471-3449-7_12

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  • DOI: https://doi.org/10.1007/978-1-4471-3449-7_12

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-3451-0

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