Obstructive Pulmonary Diseases

  • Henri G. Colt
  • Colleen J. Bergin


Asthma is a common respiratory disorder that affects up to 6% of Americans. In the United States 4.8 million school children suffer from asthma, resulting in more than 10 million lost school days annually. During the 1980s, hospitalizations caused by asthma increased by 24% for individuals over the age of 20. Nearly 5000 asthma-related deaths occurred in the United States in 1992 [1].


Chronic Obstructive Pulmonary Disease Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator Chronic Bronchitis Respir Crit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    National Center for Health Statistics. National Health Interview Survey, 1982–1992.Google Scholar
  2. 2.
    Billings J, Kretz SE, Rose R et al. (1996) National asthma education and prevention program working group report on the financing of asthma care. Am J Respir Crit Care Med 154: S119–S130.PubMedGoogle Scholar
  3. 3.
    Weiss KB, Gergen PJ, Hodgson TA (1992) An econ-omic evaluation of asthma in the United States. N Engl J Med 326: 862–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Wenzel S (1994) The role of inflammation in asthma. National Asthma Education and Prevention Program, National heart, Lung and Blood Institute, National Institutes of Health.Google Scholar
  5. 5.
    Kay AB (1996) Pathology of mild, severe, and fatal asthma. Am J Respir Crit Care Med 154: S66–S69.PubMedGoogle Scholar
  6. 6.
    Litchfield T, Lee T (1992) Asthma: cells and cytokines. J Asthma 29: 181–91.PubMedCrossRefGoogle Scholar
  7. 7.
    International Workshop on Asthma. Asthma, the important questions (part 3) (1996) Am Respir Crit Care Med 153: S2.Google Scholar
  8. 8.
    Ehrlich RI, Toit DD, Jordan E et al. (1996) Risk factors for childhood asthma and wheezing: importance of maternal and household smoking. Am J Respir Crit Care Med 154: 681–8.PubMedGoogle Scholar
  9. 9.
    Lee TH, Anderson SD (1985) Heterogeneity of mechanisms in exercise induced asthma. Thorax 40: 481–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Hogg JC (1992) Persistent and latent viral infections in the pathology of asthma. Am Rev Respir Dis 145: S7.PubMedGoogle Scholar
  11. 11.
    Johnston SL, Pattemore PK, Gwendolyn S et al. (1996) The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 154: 654–60.PubMedGoogle Scholar
  12. 12.
    Snashall PD, Chung KF (1991) State of the art: airway obstruction and bronchial hyperresponsiveness in left ventricular failure and mitral stenosis. Am Rev Respir Dis 144: 945–56.PubMedCrossRefGoogle Scholar
  13. 13.
    Colt HG, Gumbert BC, Harrell JH (1994) Tracheo-bronchial obstruction by Klebsiella Rhinoscleroma: diagnosis, pathologic features and treatment. J Bronchol 1: 31–36.CrossRefGoogle Scholar
  14. 14.
    Colt HG, Morris JF, Marston BJ et al. (1991) Necrotizing tracheitis caused by Corynebacterium pseudodiphtheriticum: unique case and review. Rev Infect Dis 13: 73–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Kikuchi Y, Okabe S, Tamura G et al. (1994) Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. N Engl J Med 330: 1329–34.PubMedCrossRefGoogle Scholar
  16. 16.
    Sly PD (1996) Peak expiratory flow monitoring in pediatric asthma: is there a role. J Asthma 33: 277–87.PubMedCrossRefGoogle Scholar
  17. 17.
    Senior BA, Kennedy DW (1996) Management of sinusitis in the asthmatic patient. Ann Allergy Asthma immunol 77: 6–19.PubMedCrossRefGoogle Scholar
  18. 18.
    Martin RJ et al. (1987) Paradoxic vocal cord motion in presumed asthmatics. Semin Respir Crit Care Med 8: 332–7.CrossRefGoogle Scholar
  19. 19.
    Simpson WG (1995) Gastroesophageal reflux disease and asthma: diagnosis and management. Arch Intern Med 155: 798–803.PubMedCrossRefGoogle Scholar
  20. 20.
    Clerf LH (1927) Bronchoscopy as an aid in diagnosis and treatment of bronchial asthma. JAMA 89: 872–5.Google Scholar
  21. 21.
    Nakhosteen JA (1978) Bronchofiberscopy in asth-matics: a method for minimizing risk of complications. Respiration 36: 112–16.PubMedCrossRefGoogle Scholar
  22. 22.
    Sahn SA, Scoggin C (1976) Fiberoptic bronchoscopy in asthma. A word of caution. Chest 69: 39–42.PubMedCrossRefGoogle Scholar
  23. 23.
    McAlpine LG, Thompson NC (1989) Lidocaine- induced bronchoconstriction in asthmatic patients. Chest 96: 1012–15.PubMedCrossRefGoogle Scholar
  24. 24.
    Hunt LW, Swedlund HA, Gleich GJ (1996) Effect of nebulized lidocaine on severe glucocorticoid- dependent asthma. Mayo Clin Proc 71: 361–8.PubMedCrossRefGoogle Scholar
  25. 25.
    Humbert M, Robinson DS, Assoufi B et al. (1996) Safety of fiberoptic bronchoscopy in asthmatic and control subjects and effect on asthma control over two weeks. Thorax 51: 664–9.PubMedCrossRefGoogle Scholar
  26. 26.
    Djukanovic R, Wilson JW, Lai CKW et al. (1991). The safety aspects of fiberoptic bronchoscopy, bronchoalveolar lavage, and endobronchial biopsy in asthma. Am Rev Respir Dis 143: 772–7.PubMedGoogle Scholar
  27. 27.
    Van Vyve T, Chanez P, Bousquet J et al. (1991). Safety of bronchoalveolar lavage and bronchial biopsies in patients with asthma of variable severity. Chest 146: 116–21.Google Scholar
  28. 28.
    National Institutes of Health. Workshop summary: summary and recommendations of a workshop held on the investigative use of fiberoptic bronchoscopy and bronchoalveolar lavage in individuals with asthma (1991) J Allergy Clin Immunol 88:808–14.Google Scholar
  29. 29.
    Summary and recommendations of a workshop on the investigative use of fiberoptic bronchoscopy and bronchoalveolar lavage in asthmatic patients (1985) Chest 88: 136–8.CrossRefGoogle Scholar
  30. 30.
    Nakhosteen JA (1996) Role of bronchoscopy in asthma research. J Bronchol 3: 300–10.CrossRefGoogle Scholar
  31. 31.
    Hodson ME, Simon G, Batten JC (1974) Radiology of uncomplicated asthma. Thorax 29: 296–303.PubMedCrossRefGoogle Scholar
  32. 32.
    Zieverink SA, Harper AP, Holden RW et al. (1982) Emergency room radiology in asthma: an efficacy study. Radiology 145: 27–9.PubMedGoogle Scholar
  33. 33.
    Eggleson PA, Ward BH, Pierson WE (1974) Radiologic abnormalities in actue asthma in children. Pediatrics 54: 442–9.Google Scholar
  34. 34.
    Kinsella M, Muller NL, Staples C et al. (1986) Hyperinflation in asthma and emphysema: Assessment by pulmonary function testing and computed tomography. Chest 94: 286–9.CrossRefGoogle Scholar
  35. 35.
    Stern EJ, Webb WR (1993) Dynamic imaging of lung morphology with ultrafast high-resolution computed tomography. J Thorac Imag 8: 273–82.CrossRefGoogle Scholar
  36. 36.
    Lynch DA, Newell JD, Tschomper BA et al. (1993) Uncomplicated asthma in adults: Comparison of CT appearance of the lungs in asthmatic and healthy subjects. Radiology 188: 829–33.PubMedGoogle Scholar
  37. 37.
    Neeld DA, Goodman LR, Gurney JW et al. (1990) Computerized tomography in the evaluation of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis 142: 1200–5.PubMedGoogle Scholar
  38. 38.
    Assessment of asthma in the workplace (1995) ACCP Consensus statement; 108: 1084–17.Google Scholar
  39. 39.
    Alberts WM, do Pico GA (1996) Reactive airways dysfunction syndrome: 109: 1618–26.Google Scholar
  40. 40.
    ATS Guidelines for the evaluation of impairment/ disability in patients with asthma (1993) 147:1956–61.Google Scholar
  41. 41.
    Samter M, Beers RF (1968) Intolerance to aspirin: clinical studies and considerations of its pathogenesis. Ann Intern Med 68: 975–83.PubMedGoogle Scholar
  42. 42.
    Bauer BA, Reed CE, Yunginger JW et al. (1997) Incidence and outcomes of asthma in the elderly: a population-based study in Rochester, Minnesota. Chest 111: 303–10.PubMedCrossRefGoogle Scholar
  43. 43.
    Shim CS, Williams MH (1983) Relationship of wheezing to the severity of obstruction in asthma. Arch Intern Med 143: 890–2.PubMedCrossRefGoogle Scholar
  44. 44.
    Emerman CL, Cydulka RK, Skobeloff E (1996) Survey of asthma practice among emergency physi-cians. Chest 109: 708–12.PubMedCrossRefGoogle Scholar
  45. 45.
    Idris AH et al. (1993) Emergency department treatment of sever asthma: metered dose inhaler plus holding chamber is equivalent in effectiveness to nebulizer. Chest 103: 665–72.PubMedCrossRefGoogle Scholar
  46. 46.
    Corbridge TC, Hall JB (1995) The assessment and management of adults with status asthmaticus. Am J Respir Crit Care 151: 1296–316.Google Scholar
  47. 47.
    Terr Ai, Bloch DA (1996) Trends in asthma therapy in the United States 1965–1992. Ann Allergy Asthma Immunol 76: 273–81.PubMedCrossRefGoogle Scholar
  48. 48.
    National Asthma Education Program. Guidelines for the diagnosis and management of asthma. Bethesda, MD: National Heart, Lung, and Blood Institute (1991). US Department of Health and Human Services publication NIH 91–3042.Google Scholar
  49. 49.
    Boulet LP, Chapman KR, Green LW, FitzGerald M (1994) Asthma education (review). Chest 106 (suppl 4): 184S–196S.PubMedGoogle Scholar
  50. 50.
    National asthma education and prevention program, National Heart Lung and Blood Institute, Bethesda, Maryland. National asthma education and presvention program task force. Report on the cost effectiveness, quality of care, and financing of asthma care (1996) Am J Respir Crit Care Med 154 3: S82.Google Scholar
  51. 51.
    Irwin RS, Curley FJ, French CL (1993) Difficult to control asthma: contributing factors and outcome of a systematic management protocol. Chest; 103: 1662–9.PubMedCrossRefGoogle Scholar
  52. 52.
    Waalkens HJ, Van Essen-Zandvliet EE, Highs MD et al. (1993) Cessation of long-term treatment with inhaled corticosteroid (budesonide) in children with asthma results in deterioration. Am Rev Respir Dis 148: 1252–7.PubMedGoogle Scholar
  53. 53.
    Woolcock AJ (1996) Corticosteroid-resistant asthma: definitions. Am J Respir Crit Care Med 154: S45–S48.PubMedGoogle Scholar
  54. 54.
    Boorsma M, Andersson N, Larsson P (1996) Assessment of the relative systemic potency of inhaled Fluticasone and Budesonide. Eur Respir J 9: 1427–32.PubMedCrossRefGoogle Scholar
  55. 55.
    Konig P (1993) The risks and benefits of inhaled corticosteroids. Eur Respir Dis 3: 501–10.Google Scholar
  56. 56.
    Pauwels RA, Hargreave FE, Camus P (1996) A 1– year comparison of turbohaler vs pressurized metered-dose inhaler in asthmatic patients. Chest 110: 53–7.PubMedCrossRefGoogle Scholar
  57. 57.
    Page CP (1991) One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by 32–agonists. Lancet 337: 717–20.PubMedCrossRefGoogle Scholar
  58. 58.
    Grainger J, Woodman K, Pearce N et al. (1991) Prescribed fenoterol and death from asthma in New Zealand, 1981–1987: a further case-control study. Thorax 46: 105–11.PubMedCrossRefGoogle Scholar
  59. 59.
    Spitzer WO, Suissa S Ernst P et al. (1992) The use of ß agonists and the risk of death and near death from asthma. N Engl J Med 326: 501–6.PubMedCrossRefGoogle Scholar
  60. 60.
    Ziment I (1993) ß adrenergic agonist toxicity: less of a problem, more of a perception. Chest 103: 1591–7.PubMedCrossRefGoogle Scholar
  61. 61.
    British Thoracic Society (1993) Guidelines on the management of asthma. Thorax 48: l–24.Google Scholar
  62. 62.
    Thoracic Society of Australia and New Zealand: Consensus on an asthma management plan (1990) NZ Med J 103:16–18.Google Scholar
  63. 63.
    Lai S, Dorow P, Venho K et al. (1993) Nedocromil sodium is more effective than cromolyn sodium for the treatment of chronic reversible obstructive airways disease. Chest 101: 438–47.Google Scholar
  64. 64.
    Callaghan B, Teo NC, Clancy L (1992) Effects of the addition of nedocromil sodium to maintenance bronchodilator therapy in the management of chronic asthma. Chest 101: 787–92.PubMedCrossRefGoogle Scholar
  65. 65.
    Milgrom H, Bender B (1993) Current issues in the use of theophylline. Am Rev Respir Dis 147: S33.PubMedGoogle Scholar
  66. 66.
    Weinberger M, Hendeles L (1996) Theophylline in asthma. N Engl J Med 334: 1380–8.PubMedCrossRefGoogle Scholar
  67. 67.
    McFadden ER (1993) Dosages of corticosteroids in asthma. Am Rev Respir Dis 147: 1306–10.PubMedGoogle Scholar
  68. 68.
    Rowe BH, Keller JL, Oxman AD (1992) Effectiveness of steroid therapy in acute exacerbations of asthma: a meta-analysis. Am J Emerg Med 10: 301–10.PubMedCrossRefGoogle Scholar
  69. 69.
    Barnes NC (1992) Effects of corticosteroids in acute severe asthma. Thorax 47: 582–3.PubMedCrossRefGoogle Scholar
  70. 70.
    FitzGerald JM, Grunfeld A, Pare PD et al. (1997) The clinical efficacy of combination nebulized anti-cholinergic and adrenergic bronchodilators vs nebulized adrenergic bronchodilator alone in acute asthma. Chest 111: 311–15.PubMedCrossRefGoogle Scholar
  71. 71.
    Israel E, Cohn J, Dube L Drazen JM for the Zileuton Clinical Trial. Effect of treatment of Zileuton, a 5– Lipoxygenase inhibitor, in patients with asthma: a randomized controlled trial (1996) JAMA 275: 932–6.Google Scholar
  72. 72.
    Norman PS (1996) Is there a role for immunotherapy in the treatment of asthma? Yes. Am J Respir Crit Care Med 154: 1225–6.PubMedGoogle Scholar
  73. 73.
    Abramson MJ, Puy RM, Weiner JM (1995) Is allergen immunotherapy effective in asthma? A metaanalysis of randomized controlled trials. Am J Respir Crit Care Med 151: 969–74.PubMedGoogle Scholar
  74. 74.
    Global strategy for asthma management and prevention. NHLBI/WHO Workshop Report Publication No. 3659 (1995).Google Scholar
  75. 75.
    American Thoracic Society statement. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (1995) Resp Crit Care Med (supplement part 2) 152: S77–S120.Google Scholar
  76. 76.
    American Thoracic Society (1962) Chronic bronchitis, asthma, and pulmonary emphysema: a statement by the committee on diagnostic standards for nontuberculous respiratory diseases. Am Rev Respir Dis 85: 762–8.Google Scholar
  77. 77.
    Nagai A, West WW, Thurlbeck WM (1985) The National Institutes of Health IPPB Trial: pathologic studies I and II. Am Rev respir Dis 132: 937–53.PubMedGoogle Scholar
  78. 78.
    Snider GL, Kleinerman J, Thurlbeck WM et al. (1985) The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases Workshop. Am Rev Respir Dis 132: 182–5.Google Scholar
  79. 79.
    Moser KM, Bordow RA (1995) Chronic obstructive pulmonary disease: definition, epidemiology, and pathology. In: Bordow RA, Moser KM eds, Manual of clinical problems in pulmonary medicine. Ed. Little, Brown and Co, Boston.Google Scholar
  80. 80.
    Thurlbeck WM (1991) Pathology of chronic airflow obstruction. In: NS Cherniak (ed.) Chronic obstructive pulmonary disease. WB Saunders, Philadelphia, pp. 3–20.Google Scholar
  81. 81.
    Sherill DL, Lebowitz MD, Burrows B (1990) Epidemiology of chronic obstructive pulmonary disease. Clin Chest Med 11: 375–88.Google Scholar
  82. 82.
    Gross NJ (1995) Practical lessons from the Lung Health Study. J Respir Dis 16: 162–9.Google Scholar
  83. 83.
    Wedzicha JA, Cotes PM, Empey DW et al. (1985) Serum immunoreactive erythropoietin in hypoxic lung disease with and without polycythemia. Clin Sc 69: 413–22.Google Scholar
  84. 84.
    Harrison BDW, Stokes TC (1982) Secondary poly-cythemia: its causes, effects, and treatment. Br J Dis Chest 76: 313–40.PubMedCrossRefGoogle Scholar
  85. 85.
    Dingra S, Solven S, Wilson A et al. (1984). Hypomagnesemia and respiratory muscle power. Am Rev Respir Dis 129: 497–8.Google Scholar
  86. 86.
    Fisher J, Magid N, Kallman C et al. (1983) Respiratory illness and hypophosphatemia. Chest 83: 504–8.PubMedCrossRefGoogle Scholar
  87. 87.
    Epstein FH, Rosa RM (1983) Adrenergic control of serum potassium. N Engl J Med 309: 1450–1.PubMedCrossRefGoogle Scholar
  88. 88.
    Peacock MD, Johnson JE, Blanton (1994) Complications of flexible bronchoscopy in patients with severe obstructive pulmonary disease. J Bronchol 1: 181–6.Google Scholar
  89. 89.
    Fräser RG, Fräser RS, Renner JW (1976) The roentgenologic diagnosis of chronic bronchitis: a reassessment with emphasis on parahilar bronchi seen head-on. Radiology 120: 1–9.PubMedGoogle Scholar
  90. 90.
    Thurlbeck WM, Muller NM (1994) Emphysema: definition, imaging, and quantification. AJR 163: 1017–25.Google Scholar
  91. 91.
    Nicklaus TM, Stowell DW, Christiansen WR et al. (1966) The accuracy of the roentgenlogic diagnosis of chronic pulmonary emphysema. Am Rev Respir Dis 93: 889–99.PubMedGoogle Scholar
  92. 92.
    Pratt PG (1987) Role of conventional chest radio-graphy in diagnosis and exclusion of emphysema. Am J Med 82: 998–1006.PubMedCrossRefGoogle Scholar
  93. 93.
    Bergin CJ, Muller NL, Miller RR (1986) CT in the qualitative assessment of emphysema. J Thorac Imaging 1: 94.PubMedCrossRefGoogle Scholar
  94. 94.
    Bergin CJ, Muller N, Nichols DM et al. (1986) The diagnosis of emphysema: a Computed Tomographic- pathologic correlation. Am Rev Respir Dis 133: 541–6.PubMedGoogle Scholar
  95. 95.
    Webb WR (1994) High resolution computed tomography of obstructive lung disease. Radiol Clin North Am 32: 745–5.PubMedGoogle Scholar
  96. 96.
    Miniati M, Filippi E, Falaschi F et al. (1995) Radiologic evaluation of emphysema in patients with chronic obstructive pulmonary disease. Chest radiography versus high resolution computed tomography. Am J Resp Crit Care Med 151: 1359–61.PubMedGoogle Scholar
  97. 97.
    Foster WL Jr, Pratt PC, Roggli VL et al. (1986) Centrilobular emphysema: CT-pathologic correlation. Radiology 159: 27–32.PubMedGoogle Scholar
  98. 98.
    Miller RR, Muller NL, Vedal S et al. (1989) Limitations of computed tomography in the assessment of emphysema. Am Rev Respir Dis 139: 980–3.PubMedGoogle Scholar
  99. 99.
    Sloane RM, Gierada DS (1996) Radiology of pul-monary emphysema and lung volume reduction surgery. Sem Thorac Cardiovasc Surgery 8: 61–82.Google Scholar
  100. 100.
    American Thoracic Society (1989) Guidelines for the approach to the patients with severe hereditary alpha! antitrypsin deficiency. Am Rev Respir Dis 140: 1494–7.Google Scholar
  101. 101.
    Eriksson S (1989) Alpha! antitrypsin deficiency: lessons learned from the bedside to the gene and back again. Chest 95: 181–9.PubMedCrossRefGoogle Scholar
  102. 102.
    Gadek JE (1996) Alphai antitrypsin: a world view. Chest (supplement) 110: 237S–294S.Google Scholar
  103. 103.
    Turino GM, Barker AF, Brantly ML et al. (1996) Clinical features of individuals with PiSZ phenotype of Aphai antitrypsin deficiency. Am J Respir Crit Care Med 154: 1718–25.PubMedGoogle Scholar
  104. 104.
    Bruce RM, Cohen BH, Diamond EL (1984) Collaborative study to assess risk of lung disease in PiMZ phenotype subjects. Am Rev Respir Dis 130: 386–9.PubMedGoogle Scholar
  105. 105.
    Seershold N, Kok-jensen A (1995) Survival in relation to lung function and smoking cessation in aptients with severe hereditary Alphai antitrypsi deficiency. Am J Respir Crit Care Med 151: 369–73.Google Scholar
  106. 106.
    McElvaney NG, Stoller JK, Buist AS et al. (1997) Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute Registry of Alphai antitrypsin deviciency. Chest 111: 394–403.PubMedCrossRefGoogle Scholar
  107. 107.
    Knoell DL, Wewers MD (1995) Clinical implications of gene therapy for Alphai antitrypsin deficiency. Chest 107: 535–45.PubMedCrossRefGoogle Scholar
  108. 108.
    Chapman KR (1996) Therapeutic approaches to chronic obstructive pulmonary disease: an emerging consensus. Am J Med 100:1A5S–10S.Google Scholar
  109. 109.
    Kong HK, Belman MJ, Weingarten S (1997) Reducing length of stay for patients hosptialized with exacerbation of COPD by using a practice guideline. Chest 111: 89–94.PubMedCrossRefGoogle Scholar
  110. 110.
    Ferguson GT, Cherniak RM (1993) Management of chronic obstructive pulmonary disease. N Engl J Med 328: 1017–22.PubMedCrossRefGoogle Scholar
  111. 111.
    Wilson DO, Rogers RM (1985) Hoffman RM. Nutrition and chronic lung disease. Am Rev Respir Dis 132: 1347–65.PubMedGoogle Scholar
  112. 112.
    Gong H, Tashkin DP, Simmons MS (1984) Hypoxia- altitude simulation test. Am Rev Respir Dis 130: 980–6.PubMedGoogle Scholar
  113. 113.
    Dillard TA, Beninati WA, Berg BW (1991) Air travel in patients with chronic obstructive pulmonary disease. Arch Intern Med 151: 1793–5.PubMedCrossRefGoogle Scholar
  114. 114.
    Anthonisen NR, Manfreda J, Warren CPW et al. (1987) Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 106: 196–204.PubMedGoogle Scholar
  115. 115.
    Saint S, Bent S, Vittinghoff E etal. (1995) Antibiotics in chronic obstructive pulmonary disease exacer-bations: a meta-analysis. JAMA 273: 957–60.Google Scholar
  116. 116.
    Petty TL (1990) The National Mucolytic Study: results of a randomized, doulbe blind, placebo- controlled study of iodinated glycerol in chronic obstructive bronchitis. Chest 97: 75–83.PubMedCrossRefGoogle Scholar
  117. 117.
    Rennard SI, Serby CW, Ghafouri M et al. (1996) Extended therapy with Ipratropium is associated with improved lung function in patients with COPD: a retrospective analysis of data from seven clinical trials (1995). Chest 110: 62–70.PubMedCrossRefGoogle Scholar
  118. 118.
    Buist AS (1995) Innovations in combination bronchodilator therapy: supplement. Chest 107: 171S–210S.CrossRefGoogle Scholar
  119. 119.
    Colice GL (1996) Nebulized bronchodilators for out-patient management of stable chronic obstructive pulmonary disease. Am J Med 100:1A11S–1A18S.Google Scholar
  120. 120.
    American College of Rhumatology Taskforce on Osteoporosis Guidelines (1996) Recommendations for the prevention and treatment of glucocorticoid- induced osteoporosis. Arthritis Rheumat 39: 1791–801.Google Scholar
  121. 121.
    McEvoy CE, Niewoehner DE (1997) Adverse effects of corticosteroid therapy for COPD: a critical review. Chest 111: 732–43.PubMedCrossRefGoogle Scholar
  122. 122.
    Callahan CM, Dittus RS, Katz BP (1991) Oral corti-costeroid therapy for patients with stable chronic obstructive pulmonary disease: a meta-analysis. Ann Intern Med 114: 216–23.PubMedGoogle Scholar
  123. 123.
    Thompson WH, Nielson CP, Carvhalo P et al. (1996) Controlled trial of oral prednisone in outpatients with acute COPD exacerbation. Am J Respir Crit Care 154: 407–12.Google Scholar
  124. 124.
    Eliasson O, Hoffman J, Trueb D et al. (1986) Corticosteroids in COPD: a clinical trial and reassessment of the literature. Chest 89: 484–90.PubMedCrossRefGoogle Scholar
  125. 125.
    Niewoehner DE, Erbland ML (1996) Systemic corti-costeroids in COPD: an unresolved clinical dilemma. Chest 110: 867–9.PubMedCrossRefGoogle Scholar
  126. 126.
    Strom K, Boe J (1991) Quality assessment and pre-dictors of survival in long-term domiciliary oxygen therapy. Eur Respr J 4: 50–8.Google Scholar
  127. 127.
    Nocturnal Oxygen Therapy Trial Group (1980) Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung diseases. Ann Intern Med 93: 391–8.Google Scholar
  128. 128.
    Lacasse Y, Guyatt GH, Goldstein RS (1997) The components of a respiratory rehabilaition program: a systematic overview. Chest 111: 1077–88.PubMedCrossRefGoogle Scholar
  129. 129.
    Celli BR (1995) Pulmonary rehabilation in aptients with COPD. Am J Respir Crit Care Med 152: 861–4.PubMedGoogle Scholar
  130. 130.
    Ries AL, Kaplan RM, Limberg TM et al. (1995) Effects of pulmonary rehabilitation on physiologic and psychosocial outcomes in aptients with chronic obstructive pulmonary disease. Ann Intern Med 122: 823–32.PubMedGoogle Scholar
  131. 131.
    Heffner JE, Fahy B, Barbiere C (1996) Advance directive education during pulmonary rehabilaition. Chest 109: 373–9.PubMedCrossRefGoogle Scholar
  132. 132.
    Trulock EP (1997) Lung transplantation: state of the art. Am J Respir Crit Care Med 155: 789–818.PubMedGoogle Scholar
  133. 133.
    Kapelanski DP, Anderson MB, Kriett JM et al. (1996) Volume reduction of the native lung following single lung transplantation for emphysema. J Thorac Cardiovasc Surg 111: 898–9.PubMedCrossRefGoogle Scholar
  134. 134.
    Briffa NP, Dennis C, Higenbottam T et al. (1995) Single lung tranplantation for end stage emphysema. Thorax 50: 562–4.PubMedCrossRefGoogle Scholar
  135. 135.
    Cooper JD, Patterson GA (1996) Lung volume reduction surgery for severe emphsyema. Seminars in Thorac Cardiovasc Surg 8: 52–60.Google Scholar
  136. 136.
    Brenner M, McKenna R, Gelb A et al. (1997) Objective predictors of response for staple versus laser emphysematous lung reduction. Am J Respir Crit Care Med 155: 1295–1301.PubMedGoogle Scholar
  137. 137.
    Gelb AF, McKenna RJ, Brenner M et al. (1996) Contribution of lung and chest wall mechanics following emphysema resection. Chest: 110: 11–17.PubMedCrossRefGoogle Scholar
  138. 138.
    Sciurba FC, Rogers RM, Keenan RJ et al. (1996) Improvement in pulmonary function and elastic recoil after lung reduction surgery for diffuse emphysema. N Engl J Med 334: 1095–9.PubMedCrossRefGoogle Scholar
  139. 139.
    Weinmann GG, Hyatt R (1996) Evaluation and research in lung volume reduction surgery. Am J Respir Crit Care Med 154: 1913–18.PubMedGoogle Scholar
  140. 140.
    Colt HG, Ries AL, Brewer N, Moser K (1997) Analysis of COPD referrals for lung volume reduction surgery. J Cardiopulm Rehab 17: 248–52.CrossRefGoogle Scholar
  141. 141.
    Wakabayashi A (1995) Thoracoscopic laser pneu- moplasty in the treatment of diffuse bullous emphy-sema. Ann Thorac Surg 60: 936–42.PubMedCrossRefGoogle Scholar
  142. 142.
    McKenna RJ, Brenner M, Gelb AF et al. (1996) A randomized prospective trial of stapled lung reduction versus laser bullectomy for diffuse emphysema. J Thorac Cardiovasc Surg 111: 317–22.PubMedCrossRefGoogle Scholar
  143. 143.
    Center for Health Care Technology (1996) Lung volume reduction surgery for end-stage chronic obstructive pulmonary disease. Health technology Assessment, US Department of Health and Human Services, Agency for Health Care Policy and Research, Pub. No. 96–0062, September 1996 (no. 10 ), Roch ville, Maryland.Google Scholar
  144. 144.
    Barker AF, Bardana EJ Jr (1988) Bronchiectasis: update of an orphan disease. Am Rev Respir Dis 137: 969–78.PubMedGoogle Scholar
  145. 145.
    Cole P, Roberts D, Higgs E et al. (1985) Colonizing bacterial load: a cardinal concept in the pathogene-sis and treatment of progressive bronchiectasis due to ‘vicious circle’ host mediated damage. Thorax 40: 227.Google Scholar
  146. 146.
    Currie DC, Pavia D, Agnew JE. et al. (1987). Impaired tracheobronchial clearance of secretions in bronchiectasis. Thorax 42: 126–30.PubMedCrossRefGoogle Scholar
  147. 147.
    Davis AL, Salzman SH (1991) Bronchiectasis. In Cherniak NS, Ed Chronic obstructive pulmonary disease. WB Saunders Co, Philadelphia pp. 317–38.Google Scholar
  148. 148.
    Mallory TB (1947) The pathogenesis of bronchiec-tasis. N Engl J Med 237: 795–8.PubMedCrossRefGoogle Scholar
  149. 149.
    Laennec RTH (1819) De l’auscultation mediate ou traite du diagnostic des maladies des poumons et du coeur fonde proncipalement sur ce nouveau moyen d’exploration. Brosson et Chaude, Paris, France.Google Scholar
  150. 150.
    Adebonoko SA, Grillo IA, Osinowo O et al. (1982) Suppurative diseases of the lung and pleura: a con-tinuing challenge in developing countries. Ann Thorac Surg 33: 40–7.CrossRefGoogle Scholar
  151. 151.
    Luce (1988) Bronchiectasis. In: Murray JF, Nadel JA eds Textbook of respiratory medicine. Saunders, Philadelphia, PA, pp. 1107–25.Google Scholar
  152. 152.
    Moll HH (1932) A clinical and pathological study of bronchiectasis. Q. J Med 25: 457–69.Google Scholar
  153. 153.
    Reid LM (1950) Reduction in bronchial subdivision in bronchiectasis. Thorax 5: 233–47.PubMedCrossRefGoogle Scholar
  154. 154.
    Highsmith WE, Burch LH, Zhou Z et al. (1994) A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chlorid concentrations. N Engl J Med 331: 974–80.PubMedCrossRefGoogle Scholar
  155. 155.
    Amjad H, Richburg FD, Adler FD (1974) Kartagener syndrome. JAMA 227: 1420–2.Google Scholar
  156. 156.
    De Iongh RU, Rutland J (1995) Ciliary defects in healthy subjects, bronchiectasis, and primary ciliary dyskenisia. Am J Respir Crit Care Med 151: 1559–67.PubMedGoogle Scholar
  157. 157.
    Bateson EM, Woo-Ming M (1973) Tracheo-bronchomegaly. Clin Radiol 24: 354–8.PubMedCrossRefGoogle Scholar
  158. 158.
    Jones DK, Godden D, Cavanagh P (1985) Alpha-1 antitrypsin deficiency presenting as bronchiectasis. Br J Dis Chest 79: 301–4.PubMedCrossRefGoogle Scholar
  159. 159.
    Verra F, Escudier E, Bignon J et al. (1991) Inherited factors in diffuse bronchiectasis in the adult: a prospective study. Eur Respir J 4: 937–44.PubMedGoogle Scholar
  160. 160.
    Greenberger PA, Miller TP, Roberts M et al. (1993) Allergic bronchopulmonary aspergillosis in patients with and without evidence of bronchiectasis. Ann Allergy 70: 333–8.PubMedGoogle Scholar
  161. 161.
    Kurklu EU, Williams MA, le Roux BT (1973) Bronchiectasis consequent upon foreign body retention. Thorax 28: 601–2.PubMedCrossRefGoogle Scholar
  162. 162.
    Simila S, Linna O, Lanning P et al. (1981) Chronic lung damage caused by adenovirus type 7: a ten year follow-up study. Chest 80: 127–31.PubMedCrossRefGoogle Scholar
  163. 163.
    Rosenszweig DY, Stead WW (1966) The role of tuberculosis and other forms of bronchopulmonary necrosis in the pathogenesis of bronchiectasis. Am Rev Respir Dis 93: 769–85.Google Scholar
  164. 164.
    Wallace RJ Jr, O’Brien R, Glassorth J et al. (1990) Diagnosis and treatment of disease caused by non- tuberculous mycobacteria. Am Rev Respir Dis 142: 940–53.Google Scholar
  165. 165.
    Nagaki M, Shimura S, Tanno Y et al. (1992) Role of chronic Pseudomonas aeruginosa infection in the development of bronchiectasis. Chest 102: 464–9.CrossRefGoogle Scholar
  166. 166.
    Bertolsen S, Strewe-Christiansen E, Aasted A et al. (1980) Isolated middle lobe atelectasis: aetiology, pathogenesis, and treatment of the so-called middle lobe syndrome. Thorax 35: 449–52.CrossRefGoogle Scholar
  167. 167.
    Vergese A, al-Samman M, Nabhan D et al. (1994) Bacterial bronchitis and bronchiectasis in human immunodeficiency virus infection. Arch Inter Med 154: 2086–91.CrossRefGoogle Scholar
  168. 168.
    Ellis DA, Thornely PE, Wrightman AJ et al. (1981) Present outlook in bronchiectasis: clinical and social study and review of factors influencing prognosis. Thorax 36: 659–64.PubMedCrossRefGoogle Scholar
  169. 169.
    Wesseott JL, Cole SR (1986) Traction bronchiectasis in end-stage pulmonary fibrosis. Radiology 161: 665–9.Google Scholar
  170. 170.
    Kass I, Zamel N, Dobry CA, Holzer M (1972) Bronchiectasis following ammonia burns of the respiratory tract. A review of two cases: Chest 62: 282–5.PubMedGoogle Scholar
  171. 171.
    Hilton Am, Hasleton PS, Bradlow A et al. (1984) Cutaneous vasculitis and immune complexes in severe bronchiectasis. Thorax 39: 185–91.PubMedCrossRefGoogle Scholar
  172. 172.
    Sadick NA, Fanta CH, Weinblatt ME et al. (1994) Bronchiectasis: a late feature of severe rheumatoid arthritis. Medicine 73: 161–70.CrossRefGoogle Scholar
  173. 173.
    Gibb WRG, Dhillon DP, Zilkha KJ et al. (1987) Bronchiectasis with ulcerative colitis and myelopa-thy. Thorax 42: 155–6.PubMedCrossRefGoogle Scholar
  174. 174.
    Hiller E, Rosenow EC, Olsen AM (1972) Pulmonary manifestations of the yellow nail syndrome. Chest 61: 452–8.PubMedCrossRefGoogle Scholar
  175. 175.
    Liebow AA, Hales MR, Lindskog GE (1949) Enlargement of the bronchial arteries and their anastomoses with the pulmonary arteries in bronchiectasis. Am J Pathol 25: 211–31.PubMedGoogle Scholar
  176. 176.
    Stanford W, Galvin JR (1988) The diagnosis of bronchiectasis. Clin Chest Med 9: 691–9.PubMedGoogle Scholar
  177. 177.
    Nogrady SG, Evans WV, Davies BH (1978) Reversibility of airways obsyruction in bronchiectasis. Thorax 33: 635–7.PubMedCrossRefGoogle Scholar
  178. 178.
    Glauser EM, Cood CD, Harris GBC (1996) Bronchiectasis: a review of 187 cases in children with follow-up pulmonary function studies in 58. Acta Pediatrica Scand 165: 1–16.Google Scholar
  179. 179.
    Ip M, Lauder IJ, Wong WY et al. (1993) Multivariate analysis of factors affecting pulmonary function in bronchiecatsis. Respiration 60: 45–50.PubMedCrossRefGoogle Scholar
  180. 180.
    Kim J-S, Muller NL (1997) Obstructive lung disease. In: A radiologic approach to diseases of the chest. William & William, Baltimore, Maryland, Chapter 38, pp. 709–22.Google Scholar
  181. 181.
    Thurlbeck WM (1988) Chronic airflow obstruction. In: Thurlbeck EA Pathology of the lung. Thieme, New York, pp 519–76.Google Scholar
  182. 182.
    Graham EA, Burford TH, Mayer JH (1948) Middle lobe syndrome. Postgrad Med 4: 29–43.PubMedGoogle Scholar
  183. 183.
    Bradham RR, Sealy WC, Young WCJ (1966) Chronic middle lobe infection: factors responsible for its development. Ann thorac Surg 2: 612–16.PubMedCrossRefGoogle Scholar
  184. 184.
    Culiner MM (1966) The right middle lobe syndrome: a nonobstructive complex. Dis Chest 50: 57–66.PubMedCrossRefGoogle Scholar
  185. 185.
    McGuinness G, Naidich DP, Leitman BS etal. (1993) Bronchiectasis: CT evaluation. AJR 160: 253–60.Google Scholar
  186. 186.
    Lentz D, Bergin CJ, Berry GJ etal. (1992) Diagnosis of bronchiolitis obliterans in heart-lung transplantation patients: importance of bronchial dilatation on CT. AJR 159: 463–7.Google Scholar
  187. 187.
    Aronchick JM, Miller Wr Jr (1995) Bronchiectasis. J Thorac Imag 10: 255–67.Google Scholar
  188. 188.
    Smith IE, Flower CD (1996) Review article: imaging in bronchiectasis. Br J Radiol 69: 589–93.PubMedCrossRefGoogle Scholar
  189. 189.
    Grenier PG, Maurice F, Musset D et al. (1986) Bronchiectasis: assessment by thinsection CT. Radiology. 161: 95–9.PubMedGoogle Scholar
  190. 190.
    Naidich DP, McCauley DI, Khouri NF et al. (1982) Computed tomography of bronchiectasis. J Comput Assist Tomogr 6: 437–41.PubMedCrossRefGoogle Scholar
  191. 191.
    Nicotra MB, Rivera M, Dale AM et al. (1995) Clinical, pathophysiologic, and microbiologic characterization of bronchiectasis in an aing cohort. Chest 108: 955–61.PubMedCrossRefGoogle Scholar
  192. 192.
    Agasthian T, Descamps C, Trastek VF et al. (1996) Surgical management of bronchiectasis. Ann Thorac Surg 62: 976–8.PubMedCrossRefGoogle Scholar
  193. 193.
    Dogan R, Alp M, Kaya S et al. (1988) Surgical treatment of bronchiectasis: a collective review of 487 cases. Thorac Cardio vase Surgeon 37: 183–6.CrossRefGoogle Scholar
  194. 194.
    Annest LS, Kratz JM, Crawford A (1982) Current results of treatment of bronchiectasis. J Thorac Cardiovasc Surg 83: 546–50.PubMedGoogle Scholar
  195. 195.
    Wilson JF, Decker AM (1982) The surgical management of childhood bronchiectasis: a review of 96 consecutive pulmonary resections in children with nontuberculous bronchiectasis. Ann Surg 195: 354–63.PubMedCrossRefGoogle Scholar
  196. 196.
    Konietzko NFJ, Carton RW, Leroy EP (1969) Causes of death in patients with bronchiectasis. Am Rev Respir Dis 100: 852–8.PubMedGoogle Scholar
  197. 197.
    Hayakawa K et al. (1992) Bronchial arterial embolization for haemoptysis: immediate and long term results. Cardiovasc Interv Radiol 15: 154–9.CrossRefGoogle Scholar
  198. 198.
    Mazzocco MC, Owens GR, Kirilloff LH et al. (1985) Chest percussion and postural drainage in patients with bronchiectasis. Chest 88: 360–3.PubMedCrossRefGoogle Scholar
  199. 199.
    Conway JH, Fleming JS, Perring S et al. (1992) Humidification as an adjunct to chest physiotherapy in aiding tracheobronchial clearance in patients with bronchiectasis. Respir Med 86: 109–14.PubMedCrossRefGoogle Scholar
  200. 200.
    Currie DC, Munro C, Gaskell D et al. (1986) Practice, problems and compliance with postural drainage: a survey of chronic sputum producers. Br J Dis Chest 80: 249–53.PubMedCrossRefGoogle Scholar
  201. 201.
    Barker A, O’Donnell A, Mallon K et al. (1995) Phase II trial of recombinant human Dnase in non-CF bronchiectasis. Am J Respir Crit Care Med 151: A463.Google Scholar
  202. 202.
    Elborn JS, Johnston B, Allen F et al. (1992) Inhaled steroids in patients with broncheictasis. Respir Med 86: 121–4.PubMedCrossRefGoogle Scholar
  203. 203.
    Denning DW, Van Wye JE, Lewiston NJ et al. (1991) Adjunctive therapy of allergic bronchopulmonary aspergillosis with itrakonazole. Chest 100: 813–19.PubMedCrossRefGoogle Scholar
  204. 204.
    Wallace RJ Jr, Brouwn BA, Griffith DE et al. (1994) Initial clarithromycin monotherapy for Mycobacterium avium intracellulae complex lung disease. Am J Respir Crit Care Med 149: 1335–44.PubMedGoogle Scholar
  205. 205.
    Cole PJ (1986) Inflammation: a two-edged sword- the model of bronchiectasis. Eur J Respir Dis 69: 6–15.Google Scholar
  206. 206.
    Nicotra MB (1994) Bronchiectasis. Sem Respir Infect 9: 31–40.Google Scholar
  207. 207.
    Hill SL, Morrision HM, Burnett D et al. (1986) Short term response of patients with bronchiectasis to treatment with amoxycilln given in standard or high doses orally or by inhalation. Thorax 41: 559–65.PubMedCrossRefGoogle Scholar
  208. 208.
    Currie DC, Garbett ND, Chan KL et al. (1990) Double-blind randomized study of prolonged higher-dose oral amoxycillin in purulent bronchiectasis. Q.J Med 76: 799–816.PubMedGoogle Scholar
  209. 209.
    Barker AF (1995) Bronchiectasis. Sem Thorac Cardiovasc Surg 7: 112–18.Google Scholar
  210. 210.
    Stockley RA (1988) Bronchiectasis: a management problem? Br J Dis Chest 82: 209–18.PubMedCrossRefGoogle Scholar
  211. 211.
    Stockley RA (1987) Bronchiectasis - new therapeutic approaches based on pathogenesis. Clin Chest Med 8: 481–94.PubMedGoogle Scholar
  212. 212.
    Kulczycki L, Schauf V (1974) Cystic fibrosis in Blacks in Washington DC: incidence and character-istics. Am J Dis Child 127: 64–67.PubMedGoogle Scholar
  213. 213.
    FitzSimmons SC (1993) The changing epidemiology of cystic fibrosis. J Pedatr 122: 1–9.CrossRefGoogle Scholar
  214. 214.
    Cystic fibrosis Foundation, National Cystic Fibrosis Patient Registry (1995) 1994 Annual data Report. Cystic Fibrosis Foundation Bethesda, Md.Google Scholar
  215. 215.
    Cystic Fibrosis Foundation (1990) Guidelines for patient services, evaluation, and monitoring in cystic fibrosis centers. Am J Dis Child 144: 1311–12.Google Scholar
  216. 216.
    Anderson DH (1938) Cystic fibrosis of the pancreas and its relation to celiac disease: a clinicaland pethologic study. Am J Dis Child 56: 344–95.Google Scholar
  217. 217.
    Davis PB, Del Rio JA, Müntz A et al. (1983) Sweat chloride concentration in adults with pulmonary diseases. Am Rev Respir Dis 128: 34–7.PubMedGoogle Scholar
  218. 218.
    Knowles MR, Stutts MJ, Spöck A et al. (1983) Abnormal ion permeation through cystic fibrosis respiratory epithelium. Science 221: 1067–70.PubMedCrossRefGoogle Scholar
  219. 219.
    Tsui LC, Buchwald D, Barker JC et al. (1985) Cystic fibrosis locus defined by a genetically linked poly-morphic DNA marker. Science 230: 1054–7.PubMedCrossRefGoogle Scholar
  220. 220.
    Collins FS (1992) Cystic fibrosis: molecular biology and therapeutic implications. Science 256: 774–9.PubMedCrossRefGoogle Scholar
  221. 221.
    Riordan JR, Rommens R, Kerem N et al. (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066–73.PubMedCrossRefGoogle Scholar
  222. 222.
    Rommens JM, Iannuzzi B, Kerem ML et al. (1989) Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245: 1059–65.PubMedCrossRefGoogle Scholar
  223. 223.
    Davis PB, Drumm M, Konstan MW (1996) Cystic fibrosis: state of the art. Am J Respir Crit Care Med 154: 1229–56.PubMedGoogle Scholar
  224. 224.
    Cotton CU, Davis PB (1993) The pancreas in cystic fibrosis. In: Davis PB, ed. Cystic fibrosis. Marcel Dekker, New York, pp. 161–92.Google Scholar
  225. 225.
    Stern RC, Stevens DP, Boat TF et al. (1976) Symptomatic hepatic disease in cystic fibrosis: incidence, course, and outcome of portal systemic portal shunting. Gastroenterology 70: 645–9.PubMedGoogle Scholar
  226. 226.
    McGrath SA, Basu A, Zeitlin PL (1993) Cystic fibrosis gene and protein expression during fetal lung development. Am J Respir Cell Moll Biol 8: 201–8.Google Scholar
  227. 227.
    Khan TZ, Wagener JS, Bost T et al. (1995) Early pul-monary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 151: 1075–82.PubMedGoogle Scholar
  228. 228.
    Cantin A (1995) Cystic fibrosis lung inflammation: early, sustained, and severe. Am J Respir Crit Care Med 151: 939–41.PubMedGoogle Scholar
  229. 229.
    Thomassen MJ, Demko CA, Doershik CF (1987) Cystic fibrosis: a review of pulmonary infections and interventions. Pediatr Pulmonol 3: 334–51.PubMedCrossRefGoogle Scholar
  230. 230.
    Davidson TM, Murphy C, Mitchell M et al. (1995) Management of chronic sinusitis in cystic fibrosis. Laryngoscope 105: 354–8.PubMedCrossRefGoogle Scholar
  231. 231.
    Byard PJ (1989) Relationship between clinical parameters and linear growth in children with cystic fibrosis. Am J Hum Biol 1: 719–25.CrossRefGoogle Scholar
  232. 232.
    Taussig LM, Lobeck CC, diSand’ Agnese PA et al. (1972) Fertility in males with cystic fibrosis. N Engl J Med 287: 586–9.PubMedCrossRefGoogle Scholar
  233. 233.
    Lewin LO, Byard PJ, Davis PB (1995) Effect of Pseudomonas cepacia colonization on survival and pulmonary function of cystic fibrosis patients. J Clin Epidemiol 43: 125–31.CrossRefGoogle Scholar
  234. 234.
    Henry RL, Mellis CM, Petrovic L (1992) Mucoid Pseudomonas aeruginosa is a marker of poor survival in cystic fibrosis. Pediatr Pulmonol 12: 158–61.PubMedCrossRefGoogle Scholar
  235. 235.
    Schidlow DV, Taussig LM, Knowles MR (1993) Cystic Fibrosis Foundation: consensus conference report on pulmonary complications of cystic fibrosis. Pediatr Pulmonol 15: 187–98.PubMedCrossRefGoogle Scholar
  236. 236.
    Kerem E, Reisman J, Corey M (1992) Prediction of mortality in patients with cystic fibrosis. N Engl J Med 326: 1187–91.PubMedCrossRefGoogle Scholar
  237. 237.
    American Society of Human Genetics (1992) Statement on cystic fibrosis carrier screening. Genet 51: 1443–4.Google Scholar
  238. 238.
    Davis PB, di Sant Agnese (1984) Diagnosis and treatment of cystic fibrosis: an update. Chest 85: 802–9.PubMedCrossRefGoogle Scholar
  239. 239.
    Swersky RB, Chang JB, Wisoff BG et al. (1979) Endobronchial balloon tamponade of hemoptysis in patients with cystic fibrosis. Chest 27: 262–4.Google Scholar
  240. 240.
    Sexauer WP, Shah R (1996) Monitoring of disease progression in cystic fibrosis. New insights into cystic fibrosis. 4: 7–11.Google Scholar
  241. 241.
    Soassi B, Moss AJ, Dooley RR (1971) Clinical recognition of cor pulmonale in cystic fibrosis. J Pediatr 78: 794–805.CrossRefGoogle Scholar
  242. 242.
    Henke KG, Orenstein DM (1984) Oxygen saturation during exercise in cystic fibrosis. Am Rev Respir Dis 129: 708–11.PubMedGoogle Scholar
  243. 243.
    Friedman PJ (1987) Chest radiographic findings in the adult with cystic fibrosis. Sem Roentgen 22: 114–24.CrossRefGoogle Scholar
  244. 244.
    Brasfield D, Hicks G, Soong S etal. (1980) Evaluation of scoring system of the chest radiograph in cystic fibrosis: a collaborative study. AJR 134: 1195–8.Google Scholar
  245. 245.
    Chrispin AR Norman AP (1974) The systematic evaluation of the chest radiograph in cystic fibrosis. Pediatr Radiol 2: 101–6.PubMedCrossRefGoogle Scholar
  246. 246.
    Weatherly MR, Palmer CG, Peters ME et al. (1993). Wisconsin cystic fibrosis chest radiograph scoring system. Pediatrics 91: 488–95.PubMedGoogle Scholar
  247. 247.
    Bhalla M, Turcios N, Aponte V et al. (1991) Cystic fibrosis: Scoring system with thin-section CT. Radiology 179: 783–8.PubMedGoogle Scholar
  248. 248.
    Neeld DA, Goodman LR, Gurney JW et al. (1990) Computerized tomography in the evaluation of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis 142: 1200–5.PubMedGoogle Scholar
  249. 249.
    Kuhn JP (1993) High resolution computed tomography of pediatric pulmonary parenchymal disorders. Radiologic Clin N Am 31: 533–51.Google Scholar
  250. 250.
    Tomashefski JF Jr, Bruce M, Stern RC et al. (1985) Pulmonary air cysts in cystic fibrosis: Relation of pathologic features to radiologic findings and history of pneumothorax. Human Pathol 16: 253–61.CrossRefGoogle Scholar
  251. 251.
    Logan PM, O’Laoide RM, Mulherin D et al. (1996) High resolution computed tomography in cystic fibrosis: Correlation with pulmonary function and assessment of prognostic value. Irish J Med Sci 165: 27–31.PubMedCrossRefGoogle Scholar
  252. 252.
    Ramsey BW (1996) Management of pulmonary disease in patients with cystic fibrosis. N Engl J Med 335: 179–86.PubMedCrossRefGoogle Scholar
  253. 253.
    Salathe M, O’Riordan T, Wanner A (1996) Treatment of mucociliary dysfunction. Chest 110: 1048–57.PubMedCrossRefGoogle Scholar
  254. 254.
    Thomas J, Cook DJ, Brooks D (1995) Chest physical therapy management of patients with cystic fibrosis: a meta-analysis. Am J Respir Crit Care Med 151: 846–50.PubMedGoogle Scholar
  255. 255.
    Natale JE, Pfeifle J, Homnick DN (1994) Comparision of intrapulmonary percussive ventilation and chest physiolotherapy. Chest 104: 1789–93.CrossRefGoogle Scholar
  256. 256.
    Konstan MW, Stern RC, Doershuk CF (1994) Efficacy of the flutter device for airway clearance in patients with cystic fibrosis. J Pediatr 124: 689–93.PubMedCrossRefGoogle Scholar
  257. 257.
    Smith AL (1986) Antibiotic therapy in cystic fibrosis: evaluation of clinical trials. J Pediatr 108: 866–970.PubMedCrossRefGoogle Scholar
  258. 258.
    DeGroot R, Smith AI (1987) Antibiotic pharmacokinetics in cystic fibrosis: differences and clinical significances. Clin Pharmacokinet 13: 228–53.CrossRefGoogle Scholar
  259. 259.
    Mukhopadhyay S, Singh M, Cater JI et al. (1996) Nebulized antipseudomonal antibiotic therapy in cystic fibrosis: a meta-analysis of benefits and risks. Thorax 51: 304–8.Google Scholar
  260. 260.
    Ramsey BW, Dorkin HL, Eisenberg RL et al. (1993) Efficacy of aerosolized tobramycin in patients with cystic fibrosis. N Engl J Med 328: 1740–6.PubMedCrossRefGoogle Scholar
  261. 261.
    Marks MI (1989) Antibiotic therapy for bron-chopulmonary infection in cystic fibrosis. The American approach. Antibiot Chemother 42: 229–36.PubMedGoogle Scholar
  262. 262.
    Eigen HB, Rosenstein J, FitzSimmons S et al. (1995) A multicenter study of alternate-day prednisone therapy in patients with cystic fibrosis. Cystic fibrosis Foundation Prednisone Trial Group. J Pediatr 126: 515–23.PubMedCrossRefGoogle Scholar
  263. 263.
    Konstan MW, Byard PJ, Hoppel CL et al. (1995) Effect of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med 332: 848–54.PubMedCrossRefGoogle Scholar
  264. 264.
    McElvaney NG, Doujaiji B, Moan MJ et al. (1993) Pharmacokinetics of recombinant secretory leuko- protease inhibitor aerosolized to normals and individuals with cystic fibrosis. Am Rev Respir Dis 148: 1056–60.PubMedCrossRefGoogle Scholar
  265. 265.
    Shah PI, Bush A, Canny GJ et al. (1995) Recombinant human Dnase I in cystic fibrosis patients with severe pulmonary disease: a short- term, double blind study followed by six months open-label treatment. Eur Respir J 8: 954–8.PubMedGoogle Scholar
  266. 266.
    Shak S (1995) Aerosolized recombinant human Dnase I for the treatment of cystic fibrosis. Chest 107: 65S–70S.PubMedCrossRefGoogle Scholar
  267. 267.
    Ramsey BW, Farrell PM, Pencharz P, and the Consensus Committee (1992) Nutritional assessment and management in cystic fibrosis: a consensus report. Am J Clin Nutr 55: 108–16.Google Scholar
  268. 268.
    Fellows KE, Khaw KT, Schuster S et al. (1995) Bronchial artery embolization in cystic fibrosis: technique and long-term results. J Pediatr 95: 959–63.Google Scholar
  269. 269.
    Fellows KE, Stigo L, Shuster S et al. (1975) Selective bronchial arteriography in patients with cystic fibrosis and massive hemoptysis. Radiology 114: 551–6.PubMedGoogle Scholar
  270. 270.
    McLaughlin FJ, Mathews WJ, Streider D et al. (1982) Pneumothorax in cystic fibrosis: management and outcome. J Pediatr 100: 863–9.PubMedCrossRefGoogle Scholar
  271. 271.
    Tribble CG, Selden RF, Rodgers BM (1986) Talc poudrage in the treatment of spontaneous pneumothoxces in patients with cystic fibrosis. Ann Surg 204: 677–80.PubMedCrossRefGoogle Scholar
  272. 272.
    Rich RH, Warwick WJ, Leonard AS (1978) Open thoracotomy and pleural abrasion in the treatment of spontaneous pneumothorax in cystic fibrosis. J Pediatr Surg 13: 237–42.PubMedCrossRefGoogle Scholar
  273. 273.
    Noyes BE, Orenstein DM (1992) Treatment of pneu-mothorax in cystic fibrosis in the era of lung trans-plantation. Chest 101: 1187–8.PubMedCrossRefGoogle Scholar
  274. 274.
    Ciriaco P, Egan TM, Cairns EL et al. (1995) Analysis of Cystic fibrosis referrals for lung transplantation. Chest 107: 1323–7.PubMedCrossRefGoogle Scholar
  275. 275.
    Mallory GB Jr (1995) Lung transplantation in patients with cystic fibrosis. New insights into Cystic Fibrosis 4: 1–11.Google Scholar
  276. 276.
    Egan TM, Detterbeck MR, Mill LJ et al. (1995) Improved results of lung transplantation for patients with cystic fibrosis. J Thorac Cardiovasc Surg 109: 224–34.PubMedCrossRefGoogle Scholar
  277. 277.
    DeLeval MR, Smyth R, Whitehead B et al. (1991) Heart and lung transplantation for terminal cystic fibrosis: a 41/2 year experience. J Thoracic Cardiovasc Surg 101: 633–42.Google Scholar
  278. 278.
    Flotte TR, Solow R, Owens RA et al. (1995) Gene expression from adeno-associated virus vectors in airway epithelial cells. Am J Respir Cell Moll Biol 7: 349–56.Google Scholar
  279. 279.
    Hyde SC, Gill DR, Higgins CF et al. (1993) Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy. Nature 363: 250–5.CrossRefGoogle Scholar
  280. 280.
    Knowles MR, Hohneker KW, Zhou ZQ et al. (1995) A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N Engl J Med 333: 823–31.PubMedCrossRefGoogle Scholar

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© Springer-Verlag London Limited 1999

Authors and Affiliations

  • Henri G. Colt
  • Colleen J. Bergin

There are no affiliations available

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