Mediator Systems of Lung Injury

  • P. E. Wright
  • G. R. Bernard
  • K. L. Brigham


The lung responds to injury in a stereotypical fashion involving cellular and humoral mediators [7,18]. Regardless of the injurious agent, the same mediator systems can result in diffuse lung dysfunction or injury. Cellular mediators include polymorphonuclear leukocytes, lymphocytes, platelets and macrophages. Humoral mediator systems include the arachidonic acid cascade, histamine, kallikreins, coagulation cascade, interleukin-2 and complement. However, no one mediator system can explain all aspects of lung injury. Experimental evidence in animal models and human studies indicates that multiple mediators interact to result in diffuse lung injury regardless of the nature of the primary injury.


Lung Injury Acute Lung Injury Adult Respiratory Distress Syndrome Fibrin Degradation Product Mediator System 
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Copyright information

© Springer-Verlag London Limited 1992

Authors and Affiliations

  • P. E. Wright
  • G. R. Bernard
  • K. L. Brigham

There are no affiliations available

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