Miscellaneous Conditions: Lymphoma and Plasmacytoma; Histiocytosis X; Extranodal Sinus Histiocytosis; Teratomas and Cysts; Tumours Arising Outside of the Sinonasal Tract

  • L. Michaels


Lymphomas are classed as Hodgkin’s and non-Hodgkin’s ones. I am not aware of a case of Hodgkin’s lymphoma having occurred in the nose and paranasal sinuses. In the upper air and food passages the neoplasms considered under the generic term of non-Hodgkin’s lymphoma are most commonly seen in the palatine tonsils. Surprisingly in view of the absence of lymphoid tissue in the normal sinonasal tract, the nose and paranasal sinuses rank second to the tonsils in frequency of occurrence of non-Hodgkin’s lymphoma. The incidence of this condition is higher than in the nasopharynx, where lymphoid tissue is normally abundant. In a study of 60 cases of non-Hodgkin’s lymphoma referred to the Armed Forces Institute of Pathology between 1966 and 1977, I found in conjunction with Dr. V.J. Hyams that 16 (27%) involved the nose and paranasal sinuses, but only 10 (17%) the nasopharynx (Table 22.1). The subject of lymphomas of the nose and throat is considered in detail in Chap. 27, apart from extramedullary plasmacytomas which are dealt with below.


Plasma Cell Paranasal Sinus Frontal Sinus Dermoid Cyst Palatine Tonsil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bernstein JM, Montgomery WW, Balogh K (1966) Metastatic tumors to the maxilla, nose and paranasal sinus. Laryngoscope 76: 621–650PubMedCrossRefGoogle Scholar
  2. David VC, O’Connell JE (1986) Nasolabial cyst. Clin Otolaryngol 11: 5–8PubMedCrossRefGoogle Scholar
  3. Foucar E, Rosai J, Dorfman RF (1978) Sinus histiocytosis with massive lymphadenopathy. Ear, nose and throat manifestations. Arch Otolaryngol 104: 687–693PubMedCrossRefGoogle Scholar
  4. Foucar E, Rosai J, Dorfman RF (1984) Sinus histiocytosis with massive lymphadenopathy. An analysis of 14 deaths in a patient registry. Cancer 54: 1834–1840PubMedCrossRefGoogle Scholar
  5. Hardwood AR, Knowling MA, Bergsagel DE (1981) Radiotherapy of extramedullary plasmacytoma of the head and neck. Clin Radiol 32: 31–36CrossRefGoogle Scholar
  6. Heffner DK, Hyams VJ (1984) Teratocarcinoma (malignant teratoma?) of the nasal cavity and paranasal sinuses: a clinicopathologic study of 20 cases. Cancer 53: 2140–2154PubMedCrossRefGoogle Scholar
  7. Kapadia SB, Desai U, Chen VS (1982) Extramedullary plasmacytoma of the head and neck. A clinicopathologic study of 26 cases. Medicine 61: 317–329PubMedCrossRefGoogle Scholar
  8. McAvoy JM, Zuckerbaum L (1976) Dermoid cysts of the head and neck in children. Arch Otolaryngol 102: 529–531PubMedCrossRefGoogle Scholar
  9. Michaels L (1984) Pathology of the larynx. Springer, Berlin Heidelberg New York TokyoCrossRefGoogle Scholar
  10. Michaels L, Hyams VJ (1979) Amyloid in localized deposits and plasmacytoma of the respiratory tract. J Pathol 128: 29–38PubMedCrossRefGoogle Scholar
  11. Miyamoto R, Helmus C (1973) Hypernephroma metastatic to the head and neck. Laryngoscope 83: 898–905PubMedCrossRefGoogle Scholar
  12. Rosai J, Dorfman RF (1969) Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol 87: 63–70PubMedGoogle Scholar
  13. Stout AP, Kenney FR (1949) Primary plasma cell tumors of upper air passages and oral cavity. Cancer 2: 261–278PubMedCrossRefGoogle Scholar
  14. Wiltshaw E (1976) The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine 55: 217–238PubMedCrossRefGoogle Scholar
  15. Wright DH, Isaacson PG (1983) Biopsy pathology of the lymphoreticular system. Chapman and Hall, LondonGoogle Scholar
  16. Wright DH, Richards DB (1981) Sinus histiocytosis with massive lympadenopathy (Rosai-Dorfman disease): report of a case with widespread nodal and extranodal dissemination. Histopathology 5: 697–709PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • L. Michaels
    • 1
    • 2
  1. 1.Department of Pathology and BacteriologyInstitute of Laryngology and Otology (University of London)LondonEngland
  2. 2.Royal National Throat, Nose and Ear HospitalLondonEngland

Personalised recommendations