The Pancreas in Diabetes Mellitus and Haemochromatosis

  • A. H. Cruickshank


In the great majority of cases of human diabetes mellitus the syndrome is primary and idiopathic, but diabetes has long been known to be an inevitable consequence of complete excision of the pancreas, or sometimes even of partial destruction of the panceas by injury or disease, while in experimental animals, selective toxic destruction of the islets of Langerhans will cause diabetes mellitus. Diabetes may also develop as a secondary consequence of over-function of the cortex or medulla of the suprarenal glands, the anterior pituitary, the thyroid gland or secretory neoplasms of any of these endocrine organs.


Beta Cell Islet Cell Islet Cell Antibody Acanthosis Nigricans Exocrine Pancreatic Function 
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  1. Alviggi L, Hoskins PJ, Pyke DA, Johnston C, Tee DEH, Leslie RDG, Vergani D (1984) Pathogenesis of insulin-dependent diabetes; a role for activated T lymphocytes. Lancet II:4–6CrossRefGoogle Scholar
  2. Barnett AH, Eff C, Lesile RDG, Pyke DA (1981) Diabetes in identical twins. A study of 200 pairs. Diabetologia 20:8 7–93Google Scholar
  3. Bell ET (1959) Hyalinization of the islets of Langerhans in nondiabetic individuals. Am J Pathol 35:801–805PubMedGoogle Scholar
  4. Bhatnagar SK, Amin MMA, Al-Yusuf AR (1984) Diabetogenic effects of nifedipine. Br Med JIH: 19Google Scholar
  5. Bostrom K (1968) Patho-anatomical findings in a case of mumps with pancreatitis, myocarditis, orchitis, epididymitis, and seminal vesicufitis. Virchows Arch Abt A Pathol Anat 344:111–117CrossRefGoogle Scholar
  6. Bottazzo GF (1984) B-cell damage in diabetic insufitis: Are we approaching a solution. Diabetologia 26:241–249Google Scholar
  7. Cecil RL (1909) A study of the pathological anatomy of the pancreas in ninety cases of diabetes mellitus. J Exp Med 11:266–290PubMedCrossRefGoogle Scholar
  8. Cerasi E, Luft R (1967) The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus. Acta Endocrinol 55:278–304PubMedGoogle Scholar
  9. Craighead JE (1978) Current views on the etiology of insulin-dependent diabetes mellitus. N Engl J Med 299:1439–1445PubMedCrossRefGoogle Scholar
  10. Cudworth AG, Festenstein H (1978) HLA genetic heterogeneity in diabetes mellitus. Br Med Bull 34:285–289PubMedGoogle Scholar
  11. Dadone MM, Kushner JP, Edwards CQ, Bishop DT, Skolnick MH (1982) Heredity and hemochromatosis. Analysis of laboratory expression of the disease by genotype in 18 pedigrees. Am J Clin Pathol 78:196–205PubMedGoogle Scholar
  12. Dandona P, Freedman DB, Foo Y, Perkins J, Katrak A, Mikhailidis DP, Rosalki SB, Beckett AG (1984) Exocrine pancreatic function in diabetes melfitiis. J Cfin Pathol 37:302–306CrossRefGoogle Scholar
  13. Dodge JA, Laurence KM (1977) Congenital absence of islets of Langerhans. Arch Dis Child 52:411–413PubMedCrossRefGoogle Scholar
  14. Doniach I, Morgan AG (1973) Islets of Langerhans in juvenile diabetes mellitus. Clin Endocrinol 2:233–248CrossRefGoogle Scholar
  15. Dunn JS, Sheehan HL, McLetchie NGB (1943) Necrosis of islets of Langerhans produced experimentally. Lancet 1:484–487Google Scholar
  16. Dürr GH-K (1979) Acute pancreatitis. In: Howat HT, Sarles H (eds) The exocrine pancreas. WB Saunders, London, Chap. 15, pp 352–401Google Scholar
  17. Faber OK, Binder C, Lauritzen T, Heding LG (1976) Preserved beta-cell function and blood glucose conta-ol in insulin dependent diabetes mellitus. Diabetes 25:362Google Scholar
  18. Finch SC, Finch CA (1955) Idiopathic hemochromatosis, and iron storage disease. Medicine 34:381–430PubMedCrossRefGoogle Scholar
  19. Foufis AK, Stewart JA (1984) The pancreas in recent-onset Type I (insulin-dependent) diabetes mellitus: Insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia 26:456–461Google Scholar
  20. Frier BM, Saunders JHB, Wormsley KG, Bouchier IAD (1976) Exocrine pancreatic fimction in juvenile onset diabetes mel- Utus. Gut 17:685–691PubMedCrossRefGoogle Scholar
  21. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619–633PubMedGoogle Scholar
  22. Gepts W (1981) Islet changes in human diabetes. In: Cooperstein SJ, Watkins D (eds) The islets of Langerhans. Academic Press, New York, pp 321–366Google Scholar
  23. Gepts W, De Mey J (1978) Islet cell survival determined by morphology. An immunocjrtochemical study of the islets of Langerhans in juvenile diabetes mellitus. Diabetes 27:251–261Google Scholar
  24. Gorsuch AN, Lister J, Dean BM, Spencer KM, McNally JM, Bottazzo GF, Cudworth AG (1981) Evidence for long prediabetic period in Type I (insulin-dependent) diabetes mellitus. Lancet II:1363–1365CrossRefGoogle Scholar
  25. Helgason T, Jonasson MR (1981) Evidence for a food additive as a cause of ketosis-prone diabetes. Lancet II:716–720CrossRefGoogle Scholar
  26. Helgason T, Ewen SWB, Ross IS, Stowers JM (1982) Diabetes produced in mice by smoked/cured mutton. Lancet II: 1017–1022CrossRefGoogle Scholar
  27. Hultquist GT, Olding LB (1975) Pancreatic-island fibrosis in young infants of diabetic mothers. Lancet II:1015–1016CrossRefGoogle Scholar
  28. Ishü T, Hosoda Y, Ikegami N, Shimada H (1983) Senüe amyloid deposition. J Pathol 139:1–22CrossRefGoogle Scholar
  29. Jenson AB, Rosenberg HS, Notkins AL (1980) Pancreatic islet- cell damage in children with fatal viral infections. Lancet II:354–358Google Scholar
  30. Johnston C, Pyke DA, Cudworth AG, Wolf E (1983) HLA-DR typing in identical twins with insulin-dependent diabetes: Difference between concordant and discordant pairs. Br Med J 1:253–255Google Scholar
  31. lunker K, Egeberg J, Kromann H, Nemp J (1977) An autopsy study of the islets of Langerhans in acute-onset juvenüe diabetes mellitus. Acta Pathol Microbiol Scand Sect A 85:699–706Google Scholar
  32. Kahn CR, Flier IS, Bar RS, Archer JA, Gordon P, Martin MM, Roth J (1976) The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl I Med 294:739–745Google Scholar
  33. Karam IH, Lewitt PA, Young CW, Nowlain RE, Frankel BI, Fujiya H, Freedman ZR, Grodsky GM (1980) Insulinopenic diabetes after rodenticide (Vacor) ingestion. A unique model of acquired diabetes in man. Diabetes 29:971–978Google Scholar
  34. Kidd KK (1979) Hemochromatosis, editorial. N Engl J Med 301:209–210PubMedCrossRefGoogle Scholar
  35. Le Compte PM (1958) “Insulitis” in early juvenile diabetes. Arch Pathol 66:450–457Google Scholar
  36. Leslie RDG (1983) Causes of insulin dependent diabetes. Br Med ini:5–6Google Scholar
  37. Linke RP, Eanes ED, Termine JD, Bladen HA, Glenner GG (1976) Formation of amyloid-like fibrils from insulin and glucagon in vitro. In: Wegelius O, Pastemack A (eds) Amyloidosis. Academic Press, London, pp 371–373Google Scholar
  38. McGarvan MH, Hartroft W (1956) The prediliction of pancreatic beta cells for pigment deposition in hemochromatosis and hemosiderosis. Am J Pathol 32:631Google Scholar
  39. Maclean N, Ogilvie RF (1955) Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes 4:367–376Google Scholar
  40. Melato M, Antonutto G, Ferronato E (1977) Amyloidosis of the islets of Langerhans in relation to diabetes mellitus and aging. Beitr Pathol 160:73–81PubMedGoogle Scholar
  41. Opie EL (1900–1901) On the relation of chronic interstitial pancreatitis to the islets of Langerhans and to diabetes mellitus. J Exp Med 5:397–428Google Scholar
  42. Oli JM, Nwokolo C (1979) Diabetes after infectious hepatitis: A follow-up stiidy. Br Med J 11:926–927Google Scholar
  43. Orci L, Baetens D, Rufener C, Amherdt M, Ravazzola M, Studer P, Malaisse-Leagae F, Unger RH (1976) Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc Nati Acad Sci USA 73:1338–1342CrossRefGoogle Scholar
  44. Owens JL Jr, Howard JM (1958) Pancreatic calcification; a late sequel in the natural history of chronic alcoholism and alco holic pancreatitis. Ann Surg 147:326–338PubMedCrossRefGoogle Scholar
  45. Papadopoulos GK, Lernmark A (1983) The spectrum of islet cell antibodies. In: Davies TF (ed) Autoimmune endocrine disease. John Wüey, New York, pp 167–180Google Scholar
  46. Pearse AGE, Ewen SWB, Polak JM (1972) The genesis of apudamyloid in endocrine poljnpeptide tumours: Histochemical distinction from immunamyloid. Virchows Arch [Cell Pathol] 10:93–107Google Scholar
  47. Powell LW, Basseti; ML, Halliday JW (1980) Hemochromatosis: 1980 update. Gastiroenterology 78:374–381Google Scholar
  48. Rakieten N, Rakieten ML, Nadkami MV (1963) Studies on the diabetogenic action of strepozotocin (NSC-37917). Cancer Chemotherapy Reps 2 7:91–98Google Scholar
  49. Rayfield EJ, Yoon Ji-W (1981) Role of viruses in diabetes. In: Cooperstein SJ, Watkins D (eds) The islets of Langerhans. Academic Press, New York, pp 427–451Google Scholar
  50. Rotter JI, Rimoin DL (1981) The genetics of the glucose intolerance disorders. Am] Med 70:116–126CrossRefGoogle Scholar
  51. Sarles H, Sahel I, Staub IL, Bourry J, Laugier R (1979) Chronic pancreatitis. In: Howat HT, Sarles H (eds) The exocrine pancreas. W B Saunders, London, pp 402–439Google Scholar
  52. Scheuer PJ, Williams R, Muir AR (1962) Hepatic pathology in relatives of patients with haemochromatosis. J Pathol Bact 84:53–64CrossRefGoogle Scholar
  53. Seltzer HS, Allen EW, Herron AL Ir, Brennan MT (1967) Insulin secretion in response to glycemic stimulus: Relation of delayed initial release to carbohydrate intolerance in mild diabetes mel- Utus. I Clin Invest 46:323–335Google Scholar
  54. Sheldon IH (1935) Haemochromatosis. Oxford University Press, LondonGoogle Scholar
  55. Soler NG (1973) Acute onset diabetes due to an ACTH secreting oat cell carcinoma of the bronchus. Postgrad Med J 49:928–929PubMedCrossRefGoogle Scholar
  56. Stansfield OH, Warren S (1928) Inflammation involving the islands of Langerhans in diabetes. N Engl] Med 198:686–687CrossRefGoogle Scholar
  57. Volk BW, Wellmann KF (1977) Idiopathic diabetes. In: Volk BW, Wellmann KF (eds) The diabetic pancreas. Bailliere Tindall, London, pp 231–260Google Scholar
  58. Warren S, Root HE (1925) The pathology of diabetes with special reference to pancreatic regeneration. Am J Pathol 1:415–430PubMedGoogle Scholar
  59. Warren S, Le Compte PM, Legg MA (1966) The pathology of diabetes mellitus, 4th edn. Henry Kimpton, London, p 85Google Scholar
  60. Weichselbaum A, Stangl E (1901) Zur Kenntiiiss der feineren Veränderungen des Pankreas bei Diabetes mellitus. Wiener Klin Wochenschr 14:968–972Google Scholar
  61. Westermark P (1976) The nature of amyloid in islets of Langerhans in old age. In: Wegelius O , Pastemack A (eds) Ayloidosis. Academic Press, London, pp 533–541Google Scholar
  62. Wilkin TJ, Nicholson S (1984) Autoantibodies against human insulin. Br Med J I:349–352CrossRefGoogle Scholar
  63. Woodrow JC (1983) Update on insulin dependent diabetes. Br Medj II:1683CrossRefGoogle Scholar
  64. Yalow RS, Berson SA (1960) Immunoassay of endogenous plasma insulin in man. J Clin Invest 39:1157–1175PubMedCrossRefGoogle Scholar
  65. Yoon I-W, Austin M, Onodera T, Notkins AL (1979) Viras- induced diabetes mellitus. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173–1179PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • A. H. Cruickshank
    • 1
  1. 1.LiverpoolUK

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