Abstract
In the great majority of cases of human diabetes mellitus the syndrome is primary and idiopathic, but diabetes has long been known to be an inevitable consequence of complete excision of the pancreas, or sometimes even of partial destruction of the panceas by injury or disease, while in experimental animals, selective toxic destruction of the islets of Langerhans will cause diabetes mellitus. Diabetes may also develop as a secondary consequence of over-function of the cortex or medulla of the suprarenal glands, the anterior pituitary, the thyroid gland or secretory neoplasms of any of these endocrine organs.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Alviggi L, Hoskins PJ, Pyke DA, Johnston C, Tee DEH, Leslie RDG, Vergani D (1984) Pathogenesis of insulin-dependent diabetes; a role for activated T lymphocytes. Lancet II:4–6
Barnett AH, Eff C, Lesile RDG, Pyke DA (1981) Diabetes in identical twins. A study of 200 pairs. Diabetologia 20:8 7–93
Bell ET (1959) Hyalinization of the islets of Langerhans in nondiabetic individuals. Am J Pathol 35:801–805
Bhatnagar SK, Amin MMA, Al-Yusuf AR (1984) Diabetogenic effects of nifedipine. Br Med JIH: 19
Bostrom K (1968) Patho-anatomical findings in a case of mumps with pancreatitis, myocarditis, orchitis, epididymitis, and seminal vesicufitis. Virchows Arch Abt A Pathol Anat 344:111–117
Bottazzo GF (1984) B-cell damage in diabetic insufitis: Are we approaching a solution. Diabetologia 26:241–249
Cecil RL (1909) A study of the pathological anatomy of the pancreas in ninety cases of diabetes mellitus. J Exp Med 11:266–290
Cerasi E, Luft R (1967) The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus. Acta Endocrinol 55:278–304
Craighead JE (1978) Current views on the etiology of insulin-dependent diabetes mellitus. N Engl J Med 299:1439–1445
Cudworth AG, Festenstein H (1978) HLA genetic heterogeneity in diabetes mellitus. Br Med Bull 34:285–289
Dadone MM, Kushner JP, Edwards CQ, Bishop DT, Skolnick MH (1982) Heredity and hemochromatosis. Analysis of laboratory expression of the disease by genotype in 18 pedigrees. Am J Clin Pathol 78:196–205
Dandona P, Freedman DB, Foo Y, Perkins J, Katrak A, Mikhailidis DP, Rosalki SB, Beckett AG (1984) Exocrine pancreatic function in diabetes melfitiis. J Cfin Pathol 37:302–306
Dodge JA, Laurence KM (1977) Congenital absence of islets of Langerhans. Arch Dis Child 52:411–413
Doniach I, Morgan AG (1973) Islets of Langerhans in juvenile diabetes mellitus. Clin Endocrinol 2:233–248
Dunn JS, Sheehan HL, McLetchie NGB (1943) Necrosis of islets of Langerhans produced experimentally. Lancet 1:484–487
Dürr GH-K (1979) Acute pancreatitis. In: Howat HT, Sarles H (eds) The exocrine pancreas. WB Saunders, London, Chap. 15, pp 352–401
Faber OK, Binder C, Lauritzen T, Heding LG (1976) Preserved beta-cell function and blood glucose conta-ol in insulin dependent diabetes mellitus. Diabetes 25:362
Finch SC, Finch CA (1955) Idiopathic hemochromatosis, and iron storage disease. Medicine 34:381–430
Foufis AK, Stewart JA (1984) The pancreas in recent-onset Type I (insulin-dependent) diabetes mellitus: Insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia 26:456–461
Frier BM, Saunders JHB, Wormsley KG, Bouchier IAD (1976) Exocrine pancreatic fimction in juvenile onset diabetes mel- Utus. Gut 17:685–691
Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619–633
Gepts W (1981) Islet changes in human diabetes. In: Cooperstein SJ, Watkins D (eds) The islets of Langerhans. Academic Press, New York, pp 321–366
Gepts W, De Mey J (1978) Islet cell survival determined by morphology. An immunocjrtochemical study of the islets of Langerhans in juvenile diabetes mellitus. Diabetes 27:251–261
Gorsuch AN, Lister J, Dean BM, Spencer KM, McNally JM, Bottazzo GF, Cudworth AG (1981) Evidence for long prediabetic period in Type I (insulin-dependent) diabetes mellitus. Lancet II:1363–1365
Helgason T, Jonasson MR (1981) Evidence for a food additive as a cause of ketosis-prone diabetes. Lancet II:716–720
Helgason T, Ewen SWB, Ross IS, Stowers JM (1982) Diabetes produced in mice by smoked/cured mutton. Lancet II: 1017–1022
Hultquist GT, Olding LB (1975) Pancreatic-island fibrosis in young infants of diabetic mothers. Lancet II:1015–1016
Ishü T, Hosoda Y, Ikegami N, Shimada H (1983) Senüe amyloid deposition. J Pathol 139:1–22
Jenson AB, Rosenberg HS, Notkins AL (1980) Pancreatic islet- cell damage in children with fatal viral infections. Lancet II:354–358
Johnston C, Pyke DA, Cudworth AG, Wolf E (1983) HLA-DR typing in identical twins with insulin-dependent diabetes: Difference between concordant and discordant pairs. Br Med J 1:253–255
lunker K, Egeberg J, Kromann H, Nemp J (1977) An autopsy study of the islets of Langerhans in acute-onset juvenüe diabetes mellitus. Acta Pathol Microbiol Scand Sect A 85:699–706
Kahn CR, Flier IS, Bar RS, Archer JA, Gordon P, Martin MM, Roth J (1976) The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl I Med 294:739–745
Karam IH, Lewitt PA, Young CW, Nowlain RE, Frankel BI, Fujiya H, Freedman ZR, Grodsky GM (1980) Insulinopenic diabetes after rodenticide (Vacor) ingestion. A unique model of acquired diabetes in man. Diabetes 29:971–978
Kidd KK (1979) Hemochromatosis, editorial. N Engl J Med 301:209–210
Le Compte PM (1958) “Insulitis” in early juvenile diabetes. Arch Pathol 66:450–457
Leslie RDG (1983) Causes of insulin dependent diabetes. Br Med ini:5–6
Linke RP, Eanes ED, Termine JD, Bladen HA, Glenner GG (1976) Formation of amyloid-like fibrils from insulin and glucagon in vitro. In: Wegelius O, Pastemack A (eds) Amyloidosis. Academic Press, London, pp 371–373
McGarvan MH, Hartroft W (1956) The prediliction of pancreatic beta cells for pigment deposition in hemochromatosis and hemosiderosis. Am J Pathol 32:631
Maclean N, Ogilvie RF (1955) Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes 4:367–376
Melato M, Antonutto G, Ferronato E (1977) Amyloidosis of the islets of Langerhans in relation to diabetes mellitus and aging. Beitr Pathol 160:73–81
Opie EL (1900–1901) On the relation of chronic interstitial pancreatitis to the islets of Langerhans and to diabetes mellitus. J Exp Med 5:397–428
Oli JM, Nwokolo C (1979) Diabetes after infectious hepatitis: A follow-up stiidy. Br Med J 11:926–927
Orci L, Baetens D, Rufener C, Amherdt M, Ravazzola M, Studer P, Malaisse-Leagae F, Unger RH (1976) Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc Nati Acad Sci USA 73:1338–1342
Owens JL Jr, Howard JM (1958) Pancreatic calcification; a late sequel in the natural history of chronic alcoholism and alco holic pancreatitis. Ann Surg 147:326–338
Papadopoulos GK, Lernmark A (1983) The spectrum of islet cell antibodies. In: Davies TF (ed) Autoimmune endocrine disease. John Wüey, New York, pp 167–180
Pearse AGE, Ewen SWB, Polak JM (1972) The genesis of apudamyloid in endocrine poljnpeptide tumours: Histochemical distinction from immunamyloid. Virchows Arch [Cell Pathol] 10:93–107
Powell LW, Basseti; ML, Halliday JW (1980) Hemochromatosis: 1980 update. Gastiroenterology 78:374–381
Rakieten N, Rakieten ML, Nadkami MV (1963) Studies on the diabetogenic action of strepozotocin (NSC-37917). Cancer Chemotherapy Reps 2 7:91–98
Rayfield EJ, Yoon Ji-W (1981) Role of viruses in diabetes. In: Cooperstein SJ, Watkins D (eds) The islets of Langerhans. Academic Press, New York, pp 427–451
Rotter JI, Rimoin DL (1981) The genetics of the glucose intolerance disorders. Am] Med 70:116–126
Sarles H, Sahel I, Staub IL, Bourry J, Laugier R (1979) Chronic pancreatitis. In: Howat HT, Sarles H (eds) The exocrine pancreas. W B Saunders, London, pp 402–439
Scheuer PJ, Williams R, Muir AR (1962) Hepatic pathology in relatives of patients with haemochromatosis. J Pathol Bact 84:53–64
Seltzer HS, Allen EW, Herron AL Ir, Brennan MT (1967) Insulin secretion in response to glycemic stimulus: Relation of delayed initial release to carbohydrate intolerance in mild diabetes mel- Utus. I Clin Invest 46:323–335
Sheldon IH (1935) Haemochromatosis. Oxford University Press, London
Soler NG (1973) Acute onset diabetes due to an ACTH secreting oat cell carcinoma of the bronchus. Postgrad Med J 49:928–929
Stansfield OH, Warren S (1928) Inflammation involving the islands of Langerhans in diabetes. N Engl] Med 198:686–687
Volk BW, Wellmann KF (1977) Idiopathic diabetes. In: Volk BW, Wellmann KF (eds) The diabetic pancreas. Bailliere Tindall, London, pp 231–260
Warren S, Root HE (1925) The pathology of diabetes with special reference to pancreatic regeneration. Am J Pathol 1:415–430
Warren S, Le Compte PM, Legg MA (1966) The pathology of diabetes mellitus, 4th edn. Henry Kimpton, London, p 85
Weichselbaum A, Stangl E (1901) Zur Kenntiiiss der feineren Veränderungen des Pankreas bei Diabetes mellitus. Wiener Klin Wochenschr 14:968–972
Westermark P (1976) The nature of amyloid in islets of Langerhans in old age. In: Wegelius O , Pastemack A (eds) Ayloidosis. Academic Press, London, pp 533–541
Wilkin TJ, Nicholson S (1984) Autoantibodies against human insulin. Br Med J I:349–352
Woodrow JC (1983) Update on insulin dependent diabetes. Br Medj II:1683
Yalow RS, Berson SA (1960) Immunoassay of endogenous plasma insulin in man. J Clin Invest 39:1157–1175
Yoon I-W, Austin M, Onodera T, Notkins AL (1979) Viras- induced diabetes mellitus. Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173–1179
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Cruickshank, A.H. (1986). The Pancreas in Diabetes Mellitus and Haemochromatosis. In: Pathology of the Pancreas. Springer, London. https://doi.org/10.1007/978-1-4471-3329-2_5
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3329-2_5
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3331-5
Online ISBN: 978-1-4471-3329-2
eBook Packages: Springer Book Archive