Advertisement

Effects upon the Pancreas of Disease in Various Organs and Systems

  • A. H. Cruickshank

Abstract

It seems likely that a certain amount of disturbance of the function of the pancreas will occur during almost any severe illness especially when there is fever, bacteraemia and toxaemia, but studies of pancreatic function are usually irrelevant and unjustified in the diagnosis and treatment of such diseases. During scarlet fever, for example, Véghelyi (1949) demonstrated an increased output of pancreatic enzymes in the pancreatic juice and a rise in the pancreatic enzymes in the blood during the first days of the illness, followed, after the first week, by a fall in the activity of the pancreatic enzymes in the duodenal juice and a marked increase in the blood levels of these enzymes, with a return to normality during the fourth week. In illnesses in which shock has occurred, or if there has been hypothermia, the effects upon the pancreas may be very marked. The effects of shock and of hypothermia are discussed in the chapter on pancreatitis. In arterial disease, especially if hypertension of the mahgnant type is present or if there is periarteritis nodosa, there may be infarcts or other marked lesions in the pancreas and these lesions are discussed in a separate chapter. In cirrhosis of the liver and in ulcerative colitis it is common for a variety of lesions that have usually had no recognisable effects upon the patient’s illness to be found at autopsy, while in renal failure and some other conditions associated with dehydration, a characteristic type of acinar ectasia may be found in the pancreas, although there is seldom any clinical or biochemical evidence of pancreatic damage.

Keywords

Systemic Lupus Erythematosus Cystic Fibrosis Acute Pancreatitis Acinar Cell Primary Biliary Cirrhosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adrian TE, Mckiernan J, Johnston DI, fflUer EJ, Vyas H, Sarson DL, Bloom SR (1980) Pancreatic gut hormone abnormalities in cystic fibrosis. Gut 21: A 448Google Scholar
  2. Allen RA, Baggenstoss AH (1955) The pathogenesis of fibrocystic disease of the pancreas. Am J Pathol 31:337–351PubMedGoogle Scholar
  3. Andersen DH (1938) Cystic fibrosis of the pancreas and its relation to celiac disease. Am J Dis Child 56:344–399Google Scholar
  4. Anderson CM, Goodchild MC (1976) Cystic fibrosis. Blackwell, Oxford, pp 1–23Google Scholar
  5. Baar HS (1953) Fibrocystic disease of the pancreas. Lancet n:80–83Google Scholar
  6. Baggenstoss AH (1947) The pancreas in uremia. Am J Pathol 23:908PubMedGoogle Scholar
  7. Baggenstoss AH (1948a) The pancreas in uremia: A histopathologic study. Am J Pathol 24:1003–1017PubMedGoogle Scholar
  8. Baggenstoss AH (1948b) Dilatation of the acini of the pancreas. Arch Pathol 45:463–473Google Scholar
  9. Ban WP, Baggenstoss AH, Bargen JA (1950) Arch Pathol 50:347–358Google Scholar
  10. Bartman J, Landing BH (1966) Morphology of the sweat apparatus in cystic fibrosis. Am J Clin Pathol 45:455–459PubMedGoogle Scholar
  11. Bodian M (1952) Fibrocystic disease of the pancreas. Heinemann, London, pp 67–104Google Scholar
  12. Bostick WL, Rinehart JF (1950) Pathologic lesions in cystic fibrosis of the pancreas. J Pediatr 3 7:469–477Google Scholar
  13. Bothwell TH, Charlton RW (1972) Haemosiderosis. Br J Hosp Med 8:437–444Google Scholar
  14. Brown RE, Madge GE (1971) Cystic fibrosis and nesidioblastosis. Arch Pathol 92:53–57PubMedGoogle Scholar
  15. Clarke C, Hadfield G (1924) Congenital pancreatic disease with infantalism. Q J Med 17:358–364Google Scholar
  16. Crichton RR (1971) Ferritin: Structure, synthesis and function. N Engl J Med 284:1413–1422PubMedCrossRefGoogle Scholar
  17. di Sant’Agnese PA (1956) Fibrocystic disease of the pancreas, a generalised disease of exocrine glands. J Am Med Assoc 160: 846–853CrossRefGoogle Scholar
  18. di Sant’Agnese PA (1979) In: Nelson WE, Vaughn VC HI, McKay RI Ir, Behrman RE (eds) Nelson textbook of pediatrics, 11th edn. WB Saunders, Philadelphia, pp 1988–2001Google Scholar
  19. di Sant’Agnese PA, Davis PB (1976) Medical progress-research in cystic fibrosis. N Engl] Med 295:481–485, 534–541, 597–602Google Scholar
  20. di Sant’Agnese PA, Darling RC, Perera GA, Shea E (1953) Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas. Pediatrics 12:549–563Google Scholar
  21. Dixon AK, Walshe JM (1983) Pancreatic distortion due to splenomegaly in Wilson’s disease. Lancet 11:47CrossRefGoogle Scholar
  22. Emery JL (1951) Postnatal changes in the lobulation and connective tissue of the pancreas. J Anat 85:159–162PubMedGoogle Scholar
  23. Epstein O, Lake-Bakaar G, McKavanagh S, Sherlock S (1980) Pancreatic hyposecretion in primary biliary cirrhosis (PBC)—a “diy gland” disease. Gut 21:A448–449Google Scholar
  24. Epstein O, Chapman RWG, Lake-Bakaar G, Foo AY, Rosalki SB, Sherlock S (1982) The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis. Gastroenterology 83:1177–1182PubMedGoogle Scholar
  25. Farber S (1943) Pancreatic insufficiency and the celiac syndrome. N Engl J Med 229:653–657CrossRefGoogle Scholar
  26. Farber S (1944) Pathologic changes associated with pancreatic insufficiency in early life. Arch Pathol 37:238–250Google Scholar
  27. lannucci A, Mukai K, Johnson D, Burke B (1984) Endocrine pancreas in cystic fibrosis; An immunohistochemical study. Hum Pathol 15:278–284CrossRefGoogle Scholar
  28. Imrie J, Fagan D, Sturgess J (1979) Quantitative evaluation of the development of the exocrine pancreas in cystic fibrosis and control infants. Am J Pathol 95:697–708PubMedGoogle Scholar
  29. Isaacson C, Seftel HC, Keeley KJ, Bothwell TH (1961) Siderosis in the Bantu: The relationship between iron overload and cirrhosis. J Lab Clin Med 58:845–853Google Scholar
  30. Jolly RD, Thompson KG (1977) Mannosidosis—pathogenesis of lesions in exocrine cells. J Pathol 121:5 9–62Google Scholar
  31. Klass HJ, Braganza JM, Warnes TW (1979) Pancreas in primary biliary cirrhosis (PBC). Gut 20:A443Google Scholar
  32. Lambert JR, Cole M, Crozier DN, Connon JJ (1981) Intrapancreatic common bile duct compression causing jaundice in an adult with cystic fibrosis. Gastroenterology 80:169–172PubMedGoogle Scholar
  33. Liu HM, Potter EL (1962) Development of the human pancreas. Arch Pathol 74:439–452PubMedGoogle Scholar
  34. Lynch MJG, Shorthouse PH (1949) Injuries and death from lightning. Lancet 1:473–478PubMedCrossRefGoogle Scholar
  35. MacCallum WG (1940) Textbook of pathology, 7th edn. WB Saunders, Philadelphia, pp 483–484 and Fig. 256Google Scholar
  36. May CD (1954) Cystic fibrosis of the pancreas in infants and children. Thomas, Springfield, pp 10–17Google Scholar
  37. Menten ML, Kinsey WC (1949) Asymptomatic retention of pancreatic secretion. Arch Pathol 47:90–96Google Scholar
  38. Minns RA, Eden OB, Hendry GMA (1982) Pancreatic enlargement and Wilson’s disease. Lancet n:337–338Google Scholar
  39. Opie EL (1910) Disease of the pancreas, 2nd edn. Lippincott, Phüadelphia, Fig. 18Google Scholar
  40. Oppenheimer E, Esterley J (1973) Cystic fibrosis of the pancreas, morphologic findings in infants with and without pancreatic lesions. Arch Pathol 96:149–154PubMedGoogle Scholar
  41. Park RW, Grand RJ (1981) Gastrointestinal manifestations of cystic fibrosis: A review. Gastroenterology 81:1143–1161PubMedGoogle Scholar
  42. Piper WN, Helwig EB (1935) Progressive systemic sclerosis. Visceral manifestations in generalised scleroderma. Arch Dermatol 72:535–546CrossRefGoogle Scholar
  43. Pirani CL (1976) Tissue distribution of amyloid. In: Wegelius O, Pastemack A (eds) Amyloidosis, Academic Press, London, pp 33–49Google Scholar
  44. Porta E, Stein A, Patterson P (1964) Ultrastructural changes of the pancreas and liver in cystic fibrosis. Am J Clin Pathol 42:451–465PubMedGoogle Scholar
  45. Reynolds JC, Inman RD, Kimberley RP, Chuong JH, Kovacs JE, Walsh MB (1982) Acute pancreatitis in systemic lupus erythematosus: Report of twenty cases and a review of the literature. Medicine 61:25–32PubMedCrossRefGoogle Scholar
  46. Sabesin SM, Thomas LB (1964) Parenchymal siderosis in patients with preexisting portal cirrhosis. Gastroenterology 46:477–485PubMedGoogle Scholar
  47. Sass-Kortsak A, Bearn AG (1978) In: Stanbury JB, Wyngaarden JB, Fredrickson DS (eds) The metabolic basis of inherited disease, 4th edn. McGraw-Hill, New York, p 1108Google Scholar
  48. Shwachman H, Lebenthal E, Khaw KT (1975) Recurrent attacks of acute pancreatitis in patients with cystic fibrosis with normal pancreatic enzymes. Pediatrics 55:8 6–9 5Google Scholar
  49. Sochor FM, Mallory GK (1963) Lung lesions in patients dying of burns. Arch Pathol 75:303–308PubMedGoogle Scholar
  50. Stein AA, Powers SR Jr (1956) Pancreatic acinar ectasia. Arch Pathol 62:494–496Google Scholar
  51. Stinson JC Jr, Baggenstoss AH, Morlock CG (1952) Pancreatic lesions associated with cirrhosis of the liver. Am J Clin Pathol 22:117–126PubMedGoogle Scholar
  52. Tisdale WA (1961) Parenchymal siderosis in patients with cirrhosis after porta-caval shunt surgery. N Engl J Med 265:928–932PubMedCrossRefGoogle Scholar
  53. Vawter GF, Shwachman H (1979) Cystic fibrosis in adults. An autopsy study. Pathol Annual Part 2, 357–382Google Scholar
  54. Véghelyi PV (1949) Pancreatic function in scarlet fever. Pediatrics 4:94–101PubMedGoogle Scholar
  55. Walters N-I (1965) The ductular cell in pancreatic cystic fibrosis. J Pathol Bact 90:45–52CrossRefGoogle Scholar
  56. Walters N-I, Gibb DGA (1965) Cystic fibrosis and acinar ectasia of the pancreas; histochemical comparison of the intraluminal secretions. J Pathol Bact 89:89–93CrossRefGoogle Scholar
  57. Warren S, Le Compte PM, Legg MA (1966) The pathology of diabetes mellitus. Kimpton, London, pp 81 and 121Google Scholar
  58. Webb L, Smith-Laing G, Lake-Bakaar G, McKavanagh S, Sherlock S (1980) Pancreatic hypofunction in extraportal venous obsti:nction. Gut 21:22 7–231Google Scholar
  59. Wharton GK (1932) The blood supply of the pancreas with special reference to that of the islands of Langerhans. Anat Rec 53:55–76CrossRefGoogle Scholar
  60. Wilson SAK (1912) Progressive lenticular degeneration: A familial nervous disease associated with cirrhosis of the liver. Brain 34:295–509CrossRefGoogle Scholar
  61. Zuelzer WW, Newton WA Jr (1949) The pathogenesis of fibrocystic disease of the pancreas. A study of 36 cases with special reference to the pulmonary lesions. Pediatrics 4:53–69PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • A. H. Cruickshank
    • 1
  1. 1.LiverpoolUK

Personalised recommendations