Abstract
There are numerous possible complications associated with the procedure of IVF and ET. Many of these have been discussed elsewhere as they may follow treatment prior to oocyte collection, laparoscopy, embryo transfer or pregnancy. As well as these problems, the procedure carries a large number of potential biological complications which will form the basis of the present discussion. The “risks” are those which are faced by the ovum, the sperm and the zygote both while residing in the in vitro culture system and when returned to the uterine lumen for the pregnancy. Some of these risks occur as an intrinsic quality of the particular sperm and ovum used for IVF, such as chromosomal aberrations and genetically inherited diseases which are also found in a small proportion of normal pregnancies. Others may occur because of suboptimal control of the artificial environment used in the laboratory during fertilization and early development. Even when the embryo returned to the genital tract continues to grow, implants and a pregnancy commences, further complications may arise which place the quality of the pregnancy in jeopardy.
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References
Austin CR (1972) Pregnancy losses and birth defects. In: Austin CR, Short RV (eds) Reproduction in mammals, Book 2: Embryonic and fetal development. Cambridge University Press, Cambridge, pp 134–153
Biggers JD (1981) In vitro fertilization and embryo transfer in human beings. N Engl J Med 304: 336–342
Blandau RJ (1980) In vitro fertilization and embryo transfer. Fertil Steril 33: 3–11
Boué JG, Boué A (1973) Increased frequency of chromosomal anomalies in abortions after induced ovulation. Lancet i: 679–680 (letter)
Boué JG, Boué A (1976) Chromosomal anomalies in early spontaneous abortions: their consequences on early embryogenesis and in vitro growth of embryonic cells. Curr Top Pathol 62: 193–208
Edwards RG, Steptoe PC, Purdy JM (1980) Establishing full-term human pregnancies using cleaving embryos grown in vitro. Br J Obstet Gynaecol 87: 737–756
Evans MI, Mukherjee AB, Schulman JD (1980) Human in vitro fertilization. Obstet Gynecol Survey 35: 71–81
Fujimoto S, Pahlavan N, Dukelow WR (1974) Chromosome abnormalities in rabbit pre-implantation blastocysts induced by superovulation. J Reprod Fertil 40: 177–181
Jacobs PA, Angell RR, Buchanan IM, Hassold TJ, Matsuyama AM, Manual B (1978) The origin of human triploids. Ann Hum Genet 42: 49–57
Johnston WIH, Lopata A, Spiers AL (1982) Current status of the world experience in IVF. Proc Fertil Soc Aust 1, Abstract 25
Lopata A (1980) Successes and failures in human in vitro fertilization. Nature 288: 642–643
Lopata A, Johnston IWH, Hoult IJ, Speirs AI (1980) Pregnancy following intrauterine implantation of an embryo obtained by in vitro fertilization of apreovulatory egg. Fertil Steril 33: 117–120
Mahadevan MM, Trounson AO, Leeton JF, Wood C (1982) The effect of semen factors on in vitro fertilization. Proc Fertil Soc Aust 1, Abstract 72
Maudlin I, Fraser LR (1977) The effect of PMSG dose on the incidence of chromosomal anomalies in mouse embryos fertilized in vitro. J Reprod Fertil 50: 275–280
Schlesseiman JJ (1979) How does one assess the risk of abnormalities from human in vitro fertilization? Am J Obstet Gynecol 135: 135–148
Steptoe PC, Edwards RG (1976) Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet i: 880–882
Steptoe PC, Edwards RG, Purdy JM (1980) Clinical aspects of pregnancies established with cleaving embryos in vitro. Br J Obstet Gynaecol 87: 757–768
Sundstrom P, Nilsson O, Liedholm P (1981) Cleavage rate and morphology of early human embryos obtained after artificial fertilization and culture. Acta Obstet Gynecol Scand 60: 109–120
Trounson AO, Leeton JF, Wood C, Webb J, Kovacs G (1980) The investigation of idiopathic infertility by in vitro fertilization. Fertil Steril 34: 431–438
Trounson AO, Mohr LR, Wood C, Leeton JF (1982a) Effect of delayed insemination on in vitro fertilization culture and transfer of human embryos. J Reprod Fertil 64: 285–294
Trounson AO, Webb JL, Mohr LR (1982b) Development of human embryos in vitro and relationship to pregnancy. Proc Aust Soc Reprod Biol, 14th Annual Conference, p 110 (Abst).
Trounson AO, Leeton J, Besanko M, Wood C, Conti A (1983) Pregnancy established in an infertile patient after transfer of a donated embryo fertilized in vitro. Br Med J 286: 835–838
Tucker M, Smith DH, Pike I, Kemp JF, Picker RH, Saunders DM (1981) Ectopic pregnancy following in vitro fertilization and embryo transfer. Lancet ii: 1278
Wood C, Trounson A, Leeton J, Talbot JMc, Buttery B, Webb J, Wood J, Jessup D (1981) A clinical assessment of nine pregnancies obtained by in vitro fertilization and embryo transfer. Fertil Steril 35: 502–508
Wood C, Trounson AO, Leeton JF, Renou PM, Walters WAW, Buttery B, Grimwade JC, Spensley JC, Yu VY-H (1982) Clinical features of eight pregnancies resulting from in vitro fertilization and embryo transfer. Fertil Steril 38: 22–29
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© 1984 Springer-Verlag Berlin Heidelberg
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Pike, I.L. (1984). Biological Risks of In Vitro Fertilization and Embryo Transfer. In: Wood, C., Trounson, A. (eds) Clinical In Vitro Fertilization. Springer, London. https://doi.org/10.1007/978-1-4471-3317-9_10
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DOI: https://doi.org/10.1007/978-1-4471-3317-9_10
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