Treatment of Antisperm Antibodies

  • W. F. Hendry
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)


Antisperm antibodies can be detected by a number of different tests in serum, seminal plasma or cervical mucus, but a positive result does not necessarily imply that the antibodies are causing infertility (see Chap. 9). The decision to treat such antibodies, therefore, must be based upon confirmatory evidence that they are impeding the process of fertilisation.


Seminal Plasma Sperm Count Male Infertility Cervical Mucus Acta Obstet Gynecol 
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  1. Butler WT, Rossen RD (1973) Effects of corticosteroids on immunity in man. Clin Invest 52: 2629–2640CrossRefGoogle Scholar
  2. Dondero F, Isidori A, Lenzi A, Cerasaro M, Mazzili F, Giovenco Ρ, Conti С (1979) Treatment and follow-up of patients with infertility due to spermagglutinins. Fertil Steril 31: 48–51PubMedGoogle Scholar
  3. Fjallbrant В, Nilsson S (1977) Decrease of sperm antibody titer in males, and conception after treatment of chronic prostatitis. Int J Fertil 22: 255–256PubMedGoogle Scholar
  4. Fjallbrant B, Obrant О (1968) Clinical and seminal findings in men with sperm antibodies. Acta Obstet Gynecol Scand 47: 451–468PubMedCrossRefGoogle Scholar
  5. Friberg J (1974) A simple and sensitive micro method for demonstration of sperm agglutinating antibodies in serum from infertile men and women. Acta Obstet Gynecol Scand (Suppl) 36: 21–29CrossRefGoogle Scholar
  6. Halim A, Antonious D, Lane J, Blandy JP (1974) The significance of antibodies to sperm in infertile men and their wives. B J Urol 46: 65–67CrossRefGoogle Scholar
  7. Hargreave ТВ, Elton R (1982) Treatment with intermittent high-dose methylprednisolone or intermittent betamethasone for antisperm antibodies. Fertil Steril, 38, 586–590PubMedGoogle Scholar
  8. Hendry WF, Morgan H, Stedronska J, Scammell G, Chamberlain GVP (1978) The clinical significance of antisperm antibodies in male subfertility: crossed hostility testing and prednisolone treatment. In: Cohen J, Hendry WF (eds) Spermatozoa, antibodies and infertility. Blackwell, Oxford, pp 129–138Google Scholar
  9. Hendry WF, Stedronska J (1980) Mixed erythrocyte-spermatozoa antiglobulin reaction (MAR test) for detection of antibodies against spermatozoa in infertile males. J Obstet Gynaecol 1: 59–62Google Scholar
  10. Hendry WF, Stedronska J, Hughes L, Cameron KM, Pugh RCB (1979) Steroid treatment of male subfertility caused by antisperm antibodies. Lancet II: 498–500Google Scholar
  11. Hendry WF, Stedronska J, Parslow J, Hughes L (1981) The results of intermittent high dose steroid therapy for male infertility due to antisperm antibodies. Fertil Steril 36: 351–355PubMedGoogle Scholar
  12. Hendry WF, Parslow JM, Stedronska J, Wallace DMA (1982) The diagnosis of unilateral testicular obstruction in subfertile males. Br J Urol 54: 774–779PubMedCrossRefGoogle Scholar
  13. Hughes L, Ryder T, McKenzie ML, Pryse-Davies J, Stedronska J, Hendry WF (1981) The use of transmission electron microscopy to study non-spermatozoal cells in semen. In: Proceedings of the international symposium on oligozoospermia, Aquila, Italy. Raven Press, New York (in press)Google Scholar
  14. Jager S, Kremer J, Van Slochteren Draaisma T (1978) A simple method of screening for antisperm antibodies in the human male. Int J Fertil 23: 12–21PubMedGoogle Scholar
  15. Kibrick S, Belding DL, Merrill В (1952) Methods for the detection of antibodies against mammalian spermatozoa. II. A gelatin agglutination test. Fertil Steril 3: 430–438Google Scholar
  16. Kremer J, Jager S (1976) The sperm-cervical mucus contact test: A preliminary report. Fertil Steril 27: 335–340Google Scholar
  17. Kremer J, Jager S (1980) Characteristics of antispermatozoal antibodies responsible for the shaking phenomenon with special regard to immunoglobulin class and antigen-reactive sites. Int J Androl 3: 143–152PubMedCrossRefGoogle Scholar
  18. Kremer J, Jager S, Van Slochteren-Draaisma T (1978a) The ‘unexplained’ poor post-coital test. Int J Fertil 23: 277–281PubMedGoogle Scholar
  19. Kremer J, Jager S, and Kuiken J (1978b) Treatment of infertility caused by antisperm antibodies. Int J Fertil 23: 270–276PubMedGoogle Scholar
  20. Linnet L, Hjort T and Fogh-Anderson P (1981) Association between failure to impregnate after vaso-vasostomy and sperm agglutinins in semen. Lancet I: 117–119Google Scholar
  21. Macleod J (1951) Semen quality in 1000 men of known fertility and in 800 cases of infertile marriage. Fertil Steril 2: 115–139PubMedGoogle Scholar
  22. McCluskey J Gutteridge OH (1982) Avascular necrosis of bone after high doses of dexamethasone during neurosurgery Br Med J 284: 333–334CrossRefGoogle Scholar
  23. Macleod J and Gold RZ (1951) The male factor in fertility and infertility. IV. Sperm morphology in fertile and infertile marriage. Fertil Steril 2: 394–414PubMedGoogle Scholar
  24. Morgan H, Stedronska J, Hendry WF, Chamberlain GVP and Dewhurst CJ (1977) Sperm/cervical mucus hostility testing and antisperm antibodies in the husband. Lancet I: 1228–1230Google Scholar
  25. Quesada EM, Dukes CD, Deen GH and Franklin RR (1968) Genital infection and sperm agglutinating antibodies in infertile men. J Urol 99: 106–108PubMedGoogle Scholar
  26. Rumke PH (1978) Autoantigenicity of spermatozoa. In: Cohen J, Hendry WF (eds) Spermatozoa, antibodies and infertility. Blackwell, Oxford, pp 67–79Google Scholar
  27. Santomauro AG, Sciarra JJ and Varma AО (1972) A clinical investigation of the role of semen analysis and post-coital test in the evaluation of male infertility. Fertil Steril 23: 245–251PubMedGoogle Scholar
  28. Shulman S, Harlin В, Davis P and Reyniak JV (1978a) Immune infertility and new approaches to treatment. Fertil Steril 29: 309–313PubMedGoogle Scholar
  29. Shulman S, Mininberg DT, Davis JE (1978b) Significant immunologic factors in male infertility. J Urol 119: 231–234PubMedGoogle Scholar
  30. Shulman JF, Shulman S (1982) Methylprednisolone treatment of immunologic infertility in the male. Fertil Steril 38: 591–599PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1983

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  • W. F. Hendry

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