Non-Specific Treatment to Improve Fertility

  • T. B. Hargreave
Part of the Clinical Practice in Urology book series (PRACTICE UROLOG)


Specific abnormalities causing defective spermatogenesis are the exception rather than the rule. Certain clinics may attract a biased population; thus, an endocrinologist may find that a large percentage of his patients are infertile because of an endocrinological abnormality but this will reflect referral based on cases of delayed or abnormal puberty rather than infertility. In a general infertility clinic no difference has been found between fertile and infertile men with regard to 17-hydroxyandrogens and oestrogens (Walker et al. 1975) and in the dynamic response to hCG (Traub 1981). Seven only of the last 662 couples we have assessed at our clinic had established endocrinological problems. We have searched for abnormal hormonal profiles (Hargreave et al. 1977), isolated FSH deficiency (Hargreave et al. 1979) and for hyperprolactinaemia (Hargreave et al. 1981) without success. The only common positive finding is an association between falling sperm density, abnormal testicular histopathology and elevated FSH levels; thus in the majority of cases we cannot identify an hormonal basis for the problem.


Congenital Adrenal Hyperplasia Seminal Plasma Male Infertility Artificial Insemination Semen Sample 
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© Springer-Verlag Berlin Heidelberg 1983

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  • T. B. Hargreave

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