Interpretation of Histological Appearances

  • J. C. E. Underwood


Five elements are involved in the act of making a histopathological diagnosis. First, the patient who contributes the tissue and about whom biochemical, radiological, immunological, and other clinical data may be available. Secondly, the tissue itself and the histological section, a two-dimensional artifact of a three-dimensional object. Thirdly, the microscope as a diagnostic tool. Fourthly, our bank of knowledge of morphological changes in disease processes against which the tissue biopsy is assessed. And lastly, the psychology of perception, the mechanism by which the observer recognises pathological changes in the tissue.


Primary Biliary Cirrhosis Synovial Sarcoma Histological Appearance Fibrous Histiocytoma Bullous Pemphigoid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • J. C. E. Underwood
    • 1
    • 2
  1. 1.University of Sheffield Medical SchoolSheffieldEngland
  2. 2.Royal Hallamshire HospitalSheffieldEngland

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