Interpretation of Histological Appearances
Five elements are involved in the act of making a histopathological diagnosis. First, the patient who contributes the tissue and about whom biochemical, radiological, immunological, and other clinical data may be available. Secondly, the tissue itself and the histological section, a two-dimensional artifact of a three-dimensional object. Thirdly, the microscope as a diagnostic tool. Fourthly, our bank of knowledge of morphological changes in disease processes against which the tissue biopsy is assessed. And lastly, the psychology of perception, the mechanism by which the observer recognises pathological changes in the tissue.
KeywordsPrimary Biliary Cirrhosis Synovial Sarcoma Histological Appearance Fibrous Histiocytoma Bullous Pemphigoid
Unable to display preview. Download preview PDF.
- Ackerman AB (1978) Histologic diagnosis of inflammatory skin diseases. Lea & Febiger, Philadelphia, pp 157–167Google Scholar
- Gombrich EH (1972) Art and illusion, 4th edn. Phaidon, London, p 154Google Scholar
- James J (1976) Light microscopic techniques in biology and medicine. Martinus Nijhoff, The Hague Johnson FB (1972) Crystals in pathologic specimens. Pathol Annu 7:321–344Google Scholar
- Koestler A (1969) The act of creation. Pan, London, p 28Google Scholar
- Kopell HP (1969) When one diagnosis won’t do then how about two? NY State J Med 69:2441–2444Google Scholar