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Interpretation of Histological Appearances

  • J. C. E. Underwood

Abstract

Five elements are involved in the act of making a histopathological diagnosis. First, the patient who contributes the tissue and about whom biochemical, radiological, immunological, and other clinical data may be available. Secondly, the tissue itself and the histological section, a two-dimensional artifact of a three-dimensional object. Thirdly, the microscope as a diagnostic tool. Fourthly, our bank of knowledge of morphological changes in disease processes against which the tissue biopsy is assessed. And lastly, the psychology of perception, the mechanism by which the observer recognises pathological changes in the tissue.

Keywords

Primary Biliary Cirrhosis Synovial Sarcoma Histological Appearance Fibrous Histiocytoma Bullous Pemphigoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ackerman AB (1978) Histologic diagnosis of inflammatory skin diseases. Lea & Febiger, Philadelphia, pp 157–167Google Scholar
  2. Anthony PP (1973) A guide to the histological identification of fungi in tissues. J Clin Pathol 26:828–831PubMedCrossRefGoogle Scholar
  3. Dudley HAF (1968) Pay off, heuristics, and pattern recognition in the diagnostic process. Lancet 2:723–726PubMedCrossRefGoogle Scholar
  4. Gombrich EH (1972) Art and illusion, 4th edn. Phaidon, London, p 154Google Scholar
  5. James J (1976) Light microscopic techniques in biology and medicine. Martinus Nijhoff, The Hague Johnson FB (1972) Crystals in pathologic specimens. Pathol Annu 7:321–344Google Scholar
  6. Koestler A (1969) The act of creation. Pan, London, p 28Google Scholar
  7. Kopell HP (1969) When one diagnosis won’t do then how about two? NY State J Med 69:2441–2444Google Scholar
  8. Pinkus H (1960) Four-dimensional histopathology. Arch Dermatol 82:681–698PubMedCrossRefGoogle Scholar
  9. Sullivan M, King LS (1947) Effects of resin of podophyllum on normal skin, condylomata acuminata and verrucae vulgares. Arch Dermatol Syphilol 56:30–45CrossRefGoogle Scholar
  10. Underwood JCE (1974) Lymphoreticular infiltration in human tumours: Prognostic and biological implications. Br J Cancer 30:538–548PubMedCrossRefGoogle Scholar
  11. Wallington EA (1979) Artifacts in tissue sections. Med Lab Sci 36:3–61PubMedGoogle Scholar
  12. Wolman M (1970) On the use of polarized light in pathology. Pathol Annu 5:381–416PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1981

Authors and Affiliations

  • J. C. E. Underwood
    • 1
    • 2
  1. 1.University of Sheffield Medical SchoolSheffieldEngland
  2. 2.Royal Hallamshire HospitalSheffieldEngland

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