Overrepresentation of the Short Arm of Chromosome 12 Is Related to Invasive Growth of Testicular Seminomas and Non-seminomas

  • J. W. Oosterhuis
  • R. J. H. L. M. van Gurp
  • C. Rosenberg
  • L. H. J. Looijenga
Conference paper


Relative overrepresentation of the short of chromosome 12, mostly as isochromosomes (i(12p)), is considered to be characteristic for testicular germ cell tumours (TGCTs). Here we show that gain of 12p is not one of the initiating events in the development of TGCTs, but is related to invasive growth.


Germ Cell Tumour Embryonal Carcinoma Invasive Growth Testicular Germ Cell Tumour Penile Cancer 
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Copyright information

© Springer-Verlag London Limited 2002

Authors and Affiliations

  • J. W. Oosterhuis
    • 1
  • R. J. H. L. M. van Gurp
    • 1
  • C. Rosenberg
    • 2
  • L. H. J. Looijenga
    • 1
  1. 1.Pathology/Laboratory for Experimental Patho-OncologyUniversity Hospital Rotterdam/Daniel, Josephine Nefkens Institute, Erasmus University RotterdamRotterdamThe Netherlands
  2. 2.Department of Cytochemistry and CytometryLeiden University Medical CenterLeidenThe Netherlands

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