Computing and the Histopathology of Intestinal Inflammation

  • D. Jenkins

Abstract

Histopathology of mucosal biopsies provides important information in the diagnosis and understanding of many gastrointestinal diseases. In the diagnosis of inflammatory disease in the gut the two main reasons for which biopsy is undertaken are to determine whether there is significant inflammatory change, and to further its differential diagnosis. When endoscopic and histological examination are consistent, establishing a diagnosis may be relatively straightforward, but when there is uncertainty about possible minor abnormalities on either endoscopy or biopsy or the two are inconsistent, determining the significance of these changes can be very difficult. Histology is often relied upon heavily for definitive diagnosis but extracting the maximum value from this most invasive diagnostic examination is not easy. Several studies have shown that there are considerable problems with the intraobserver and interobserver repeatability of conventional histological diagnoses (Silcocks 1983).

Keywords

Covariance Shrinkage Paraffin Dermatitis Mast 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. Jenkins

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